Lentiviral vector-mediated upregulation of let-7a inhibits gastric carcinoma cell growth in vitro and in vivo

Scandinavian Journal of Gastroenterology

Volumn 46, Issue 1, 2011, Pages 53-59

  Zhu, Yimin ^a   Zhong, Zhengxiang ^a   Liu, Zhiming ^b  

^a Second Hospital of Jiaxing   (China)

^b GUANGXI MEDICAL UNIVERSITY   (China)

Author keywords

Gastric carcinoma; Genetic therapy; MicroRNA

Indexed keywords

ENHANCED GREEN FLUORESCENT PROTEIN; LENTIVIRUS VECTOR; PROTEIN LET 7A; SHORT HAIRPIN RNA; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DRUG INHIBITION; GENE CASSETTE; GENE EXPRESSION; GENE FUNCTION; GENE OVEREXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LENTIVIRINAE; MALE; MEDIATOR; MOUSE; NONHUMAN; PARENT; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR UPREGULATION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STOMACH CANCER; TUMOR XENOGRAFT; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; CARCINOMA; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE THERAPY; HUMANS; LENTIVIRUS; MALE; MICE; MICE, NUDE; MICRORNAS; STOMACH NEOPLASMS; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 78651349754     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.3109/00365521.2010.510566     Document Type: Article

References (23)

1. Ambros V. The functions of animal microRNAs, Nature 2004;431:350-5. PMID: 15372042.
2. Bartel DP, Chen CZ. Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs. Nat Rev Genet 2004;5:396-400. PMID: 15143321.
3. Kloosterman WP, Plasterk RH. The diverse functions of microRNAs in animal development and disease. Dev Cell 2006;11:441-50. PMID: 17011485.
4. Zeng Y. Principles of micro-RNA production and maturation. Oncogene 2006;25:6156-62. PMID: 17028594.
5. Valencia-Sanchez MA, Liu J, Hannon GJ. Control of trans-lation and mRNA degradation by miRNAs and siRNAs. Gene Dev 2006;20:515-24. PMID: 16510870.
6. Bentwich I, Avniel A, Karov Y. Identification of hundreds of conserved and nonconserved human microRNAs. Nat Genet 2005;37:766-70. PMID: 15965474.
7. Berezikov E, Van TG, Verheul M. Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis. Genome Res 2006;16:1289-98. PMID: 16954537.
8. Didiano D, Hobert O. Perfect seed pairing is not a generally reliable predictor for miRNA-target interactions. Nat Struct Mol Biol 2006;13:849-51. PMID: 16921378.
9. Zhu Y, Liu Z. Roles of onco-microRNAs in cancers. J Intern Oncol 2008;35(12):883-5.
10. Zhu Y, Zhong Z, Liu Z. Significance and relationship between let-7a and gastric mucosa cancerization. World J Gastroenterol 2010;16(26):3325-9. PMID: 20614490.
11. Zhang B, Metharom P, Jullie H. The significance of con-trolled conditions in lentiviral vector titration and in the use of multiplicity of infection (MOI) for prediction gene transfer events. Genet Vaccines Ther 2004;2:6. PMID: 15291957.
12. Bernard PS, Wittwer CT. Real-time PCR technology for cancer diagnostics. Clin Chem 2002;48:1178-85. PMID: 12142370.
13. Reinhart BJ, Slack FJ, Basson M. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis ele-gans. Nature 2000;403:901-6. PMID: 10706289.
14. Abrahante JE, Daul AL, Li M. The Caenorhabditis elegans hunchback-like gene lin-57/hbl-1 controls developmental time and is regulated by microRNAs. Dev Cell 2003;4: 625-37. PMID: 12737799.
15. Lin SY, Johnson SM, Abraham M. The C elegans hunchback homolog, hbl-1, controls temporal patterning and is a prob-able microRNA target. Dev Cell 2003;4:639-50. PMID: 12737800.
16. Slack FJ, Basson M, Liu Z. The lin-41 RBCC gene acts in the C elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor. Mol Cell 2000;5: 659-69. PMID: 10882102.
17. Vella MC, Choi EY, Lin SY. The C elegans microRNA let-7-binds to imperfect let-7 complementary sites from the lin-41 3'UTR. Genes Dev 2004;18:132-7. PMID: 14729570.
18. Dong Q, Meng P, Wang T, Qin W, Qin W, Wang F, et al. MicroRNA let-7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2. PLoS One 2010;5:10137-47. PMID: 20418948.
19. Yu F, Yao H, Zhu P. Let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 2007;131: 1109-23. PMID: 18083101.
20. Mayr C, Hemann MT, Bartel DP. Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transforma-tion. Science 2007;16:1576-9. PMID: 17322030.
21. Akao Y, Nakagawa Y, Naoe T. Let-7 microRNA functions as a potential growth suppressor in human colon cancer cells. Biol Pharm Bull 2006;29:903-6. PMID: 16651716.
22. Aurora E-K, Trang P, Wiggins JF. The let-7 microRNA reduces tumor growth in mouse models of lung cancer. Cell Cycle 2008;7:759-64. PMID: 18344688.
23. Motoyama K, Inoue H, Nakamura Y, Uetake H, Sugihara K, Mori M. Clinical significance of high mobility group A2 in human gastric cancer and its relationship to let-7 microRNA family. Clin Cancer Res 2008;14:2334-40. PMID: 18413822.