Predictors of non-alcoholic fatty liver disease in obese and overweight Egyptian children: Single center study

Saudi Journal of Gastroenterology

Volumn 17, Issue 1, 2011, Pages 40-46

  El Karaksy, Hanaa M ^a   El Koofy, Nehal M ^a   Anwar, Ghada M ^a   El Mougy, Fatma M ^a   El Hennawy, Ahmed ^a   Fahmy, Mona E ^a  

^a CAIRO UNIVERSITY   (Egypt)

Author keywords

Children; Egypt; NAFLD; NASH; obesity; steatosis

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; FERRITIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SERUM ALBUMIN; TRIACYLGLYCEROL;

ADOLESCENT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ANTHROPOMETRY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY HEIGHT; BODY MASS; BODY WEIGHT; CHILD; CHOLESTEROL BLOOD LEVEL; DYSLIPIDEMIA; EGYPT; FATTY LIVER; FEMALE; FERRITIN BLOOD LEVEL; HUMAN; INFORMED CONSENT; LIPID ANALYSIS; LIVER BIOPSY; LIVER FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; NONALCOHOLIC FATTY LIVER; OBESITY; PRESCHOOL CHILD; SCHOOL CHILD; SKINFOLD THICKNESS;

ADOLESCENT; AGE FACTORS; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; EGYPT; FATTY LIVER; FEMALE; HUMANS; INSULIN RESISTANCE; LIPIDS; LIVER FUNCTION TESTS; MALE; OBESITY; RISK FACTORS;

EID: 78651330143     PISSN: 13193767     EISSN: 19984049     Source Type: Journal    
DOI: 10.4103/1319-3767.74476     Document Type: Article

References (24)

1. Patton HM, Sirlin C, Behling C, Middleton M, Schwimmer JB, Lavine JE. Pediatric nonalcoholic fatty liver disease: A critical appraisal of current data and implications for future research. J Pediatr Gastroenterol Nutr 2006;43:413-27.
2. Nanda K. Non-alcoholic steatohepatitis in children. Pediatr Transplant 2004;8:613-8.
3. Mathur P, Das MK, Arora NK. Non-alcoholic fatty liver disease and childhood obesity. Indian J Pediatr 2007;74:401-7.
4. Iacobellis A, Marcellini M, Andriulli A, Perri F, Leandro G, Devito R, et al. Non invasive evaluation of liver fibrosis in paediatric patients with nonalcoholic steatohepatitis. World J Gastroenterol 2006;12:7821-5.
5. Raman M, Allard J. Non alcoholic fatty liver disease: A clinical approach and review. Can J Gastroenterol 2006;20:345-9.
6. Azzam RK, Alonso EM, Emerick KM, Whitington PF. Safety of percutaneous liver biopsy in infants less than three months old. J Pediatr Gastroenterol Nutr 2005;41:639-43.
7. Singh DK, Sakhuja P, Malhotra V, Gondal R, Sarin SK. Independent predictors of steatohepatitis and fibrosis in Asian Indian patients with non-alcoholic steatohepatitis. Dig Dis Sci 2008;53:1967-76.
8. Park JW, Jeong G, Kim SJ, Kim MK, Park SM. Predictors reflecting the pathological severity of non-alcoholic fatty liver disease: Comprehensive study of clinical and immunohistochemical findings in younger Asian patients. J Gastroenterol Hepatol 2007;22:491-7.
9. Egyptian growth curves. Diabetes Endocrine Metabolism Pediatric Unit Cairo University Childerns Hospital. Available from: .blogspot.com/. Accessed on 2009 Aug 13.
10. Fernandez JR, Redden DT, Pietrobelli A, Allison DB. Waist circumference percentiles in nationally representative samples of African-American, European-American, and Mexican-American children and adolescents. J Pediatr 2004;145 439-44.
11. Mottin CC, Moretto M, Padoin AV, Swarowsky AM, Toneto MG, Glock L, et al. The role of ultrasound in the diagnosis of hepatic steatosis in morbidly obese patients. Obes Surg 2004;14:635-7.
12. Kleiner DE, Brunt EM, van Natta M, Behling C, Contos MJ, Cummings OW, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005;41:1313-21.
13. Rashid M, Roberts EA. Nonalcoholic steatohepatitis in children. J Pediatr Gastroenterol Nutr 2000;30:48-53.
14. Ong JP, Elariny H, Collantes R, Younoszai A, Chandhoke V, Reines HD, et al. Predictors of nonalcoholic steatohepatitis and advanced fibrosis in morbidly obese patients. Obes Surg 2005;15:310-5.
15. Xanthakos S, Miles L, Bucuvalas J, Daniels S, Garcia V, Inge T. Histologic spectrum of nonalcoholic fatty liver disease in morbidly obese adolescents. Clin Gastroenterol Hepatol 2006;4:226-32.
16. Finucane FM, Teong L, Pittock S, Fallon M, Hatunic M, Costigan C, et al. Adverse metabolic profiles in a cohort of obese Irish children. Ann Clin Biochem 2008;45:206-9.
17. Dixon JB, Bhathal PS, OBrien PE. Nonalcoholic fatty liver disease: Predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology 2001;121:91-100.
18. Chitturi S, Farrell G, Frost L, Kriketos A, Lin R, Fung C, et al. Serum leptin in NASH correlates with hepatic steatosis but not fibrosis: A manifestation of lipotoxicity? Hepatology 2002;36:403-9.
19. Nobili V, Manco M. Therapeutic strategies for pediatric non-alcoholic fatty liver disease: A challenge for health care providers. World J Gastroenterol 2007; 13:2639-41.
20. Browning JD, Kumar KS, Saboorian MH, Thiele DL. Ethnic differences in the prevalence of cryptogenic cirrhosis. Am J Gastroenterol 2004;99:292-8.
21. Sharabi Y, Eldad A. Nonalcoholic fatty liver disease is associated withhyperlipidemia and obesity. Am J Med 2000;109:171.
22. Talwalkar JA. Motion- all patients with NASH need to have a liver biopsy: Arguments for the motion. Can J Gastroenterol 2002;16:718-21.
23. Manton ND, Lipsett J, Moore DJ, Davidson GP, Bourne AJ, Couper RT. Non-alcoholic steatohepatitis in children and adolescents. Med J Aust 2000;173:476-9.
24. Campos GM, Bambha K, Vittinghoff E, Rabl C, Posselt AM, Ciovica R, et al. A clinical scoring system for predicting nonalcoholic steatohepatitis in morbidly obese patients. Hepatology 2008;47:1916-23.