Variation in the nicotinic acetylcholine receptor gene cluster CHRNA5-CHRNA3-CHRNB4 and its interaction with recent tobacco use influence cognitive flexibility

Neuropsychopharmacology

Volumn 35, Issue 11, 2010, Pages 2211-2224

  Zhang, Huiping ^a,b   Kranzler, Henry R ^c   Poling, James ^a,b   Gelernter, Joel ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^c UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

Author keywords

CHRNA5 CHRNA3 CHRNB4; cognitive flexibility; gene recent tobacco use; Wisconsin Card Sorting Test

Indexed keywords

NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA3; NICOTINIC RECEPTOR ALPHA5; NICOTINIC RECEPTOR BETA4; UNCLASSIFIED DRUG;

ADULT; AFRICAN AMERICAN; ALCOHOLISM; ALLELE; ARTICLE; COCAINE DEPENDENCE; COGNITION; COGNITIVE FLEXIBILITY; CONTROLLED STUDY; FEMALE; GENE CLUSTER; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC VARIABILITY; HAPLOTYPE; HOMOZYGOTE; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; OPIATE ADDICTION; PRIORITY JOURNAL; SEMI STRUCTURED INTERVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; TOBACCO DEPENDENCE; WISCONSIN CARD SORTING TEST;

ADULT; AFRICAN AMERICANS; COGNITION; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETIC VARIATION; HUMANS; MALE; MIDDLE AGED; MULTIGENE FAMILY; NERVE TISSUE PROTEINS; NEUROPSYCHOLOGICAL TESTS; RECEPTORS, NICOTINIC; SMOKING;

EID: 78651322488     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/npp.2010.95     Document Type: Article

References (48)

1. Amos CI, Wu X, Broderick P, Gorlov IP, Gu J, Eisen T et al (2008). Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat Genet 40: 616-622.
2. Barrett JC, Fry B, Maller J, Daly MJ (2005). Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21: 263-265.
3. Berrettini W, Yuan X, Tozzi F, Song K, Francks C, Chilcoat H et al (2008). Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking. Mol Psychiatry 13: 368-373.
4. Bierut LJ, Stitzel JA, Wang JC, Hinrichs AL, Grucza RA, Xuei X et al (2008). Variants in nicotinic receptors and risk for nicotine dependence. Am J Psychiatry 165: 1163-1171.
5. Canas J, Quesada JF, Antoli A, Fajardo I (2003). Cognitive flexibility and adaptability to environmental changes in dynamic complex problem-solving tasks. Ergonomics 46: 482-501.
6. Cincotta SL, Yorek MS, Moschak TM, Lewis SR, Rodefer JS (2008). Selective nicotinic acetylcholine receptor agonists: potential therapies for neuropsychiatric disorders with cognitive dysfunction. Curr Opin Investig Drugs 9: 47-56.
7. De La Vega FM, Isaac HI, Scafe CR (2006). A tool for selecting SNPs for association studies based on observed linkage disequilibrium patterns. Pac Symp Biocomput 487-498. PMID: 7094263.
8. Ernst M, Heishman SJ, Spurgeon L, London ED (2001). Smoking history and nicotine effects on cognitive performance. Neuropsychopharmacology 25: 313-319.
9. Falush D, Stephens M, Pritchard JK (2003). Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. Genetics 164: 1567-1587.
10. Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B et al (2002). The structure of haplotype blocks in the human genome. Science 296: 2225-2229.
11. Galderisi S, Davidson M, Kahn RS, Mucci A, Boter H, Gheorghe MD et al (2009). Correlates of cognitive impairment in first episode schizophrenia: the EUFEST study. Schizophr Res 115: 104-114.
12. Gotti C, Zoli M, Clementi F (2006). Brain nicotinic acetylcholine receptors: native subtypes and their relevance. Trends Pharmacol Sci 27: 482-491.
13. Greenwood PM, Fossella JA, Parasuraman R (2005). Specificity of the effect of a nicotinic receptor polymorphism on individual differences in visuospatial attention. J Cogn Neurosci 17: 1611-1620.
14. Greve KW, Stickle TR, Love JM, Bianchini KJ, Stanford MS (2005). Latent structure of the Wisconsin Card Sorting Test: a confirmatory factor analytic study. Arch Clin Neuropsychol 20: 355-364.
15. Grucza RA, Wang JC, Stitzel JA, Hinrichs AL, Saccone SF, Saccone NL et al (2008). A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence. Biol Psychiatry 64: 922-929.
16. Hartman M, Steketee MC, Silva S, Lanning K, Andersson C (2003). Wisconsin Card Sorting Test performance in schizophrenia: the role of working memory. Schizophr Res 63: 201-217.
17. Heaton, PAR Staff (1999). Wisconsin Card Sorting Test (Computer Version 3 for Windows Research Edition). pp Psychological Assessment Resources: Odessa, FL.
18. Hung RJ, McKay JD, Gaborieau V, Boffetta P, Hashibe M, Zaridze D et al (2008). A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature 452: 633-637.
19. Jacobsen LK, D'Souza DC, Mencl WE, Pugh KR, Skudlarski P, Krystal JH (2004). Nicotine effects on brain function and functional connectivity in schizophrenia. Biol Psychiatry 55: 850-858.
20. Jacobsen LK, Krystal JH, Mencl WE, Westerveld M, Frost SJ, Pugh KR (2005). Effects of smoking and smoking abstinence on cognition in adolescent tobacco smokers. Biol Psychiatry 57: 56-66.
21. Jacobsen LK, Pugh KR, Mencl WE, Gelernter J (2006). C957T polymorphism of the dopamine D2 receptor gene modulates the effect of nicotine on working memory performance and cortical processing efficiency. Psychopharmacology (Berl) 188: 530-540.
22. Kandel DB, Chen K (2000). Extent of smoking and nicotine dependence in the United States: 1991-1993. Nicotine Tob Res 2: 263-274.
23. Lee J, Laurin N, Crosbie J, Ickowicz A, Pathare T, Malone M et al (2008). Association study of the nicotinic acetylcholine receptor alpha4 subunit gene, CHRNA4, in attention-deficit hyperactivity disorder. Genes Brain Behav 7: 53-60.
24. Lin DY, Zeng D, Millikan R (2005). Maximum likelihood estimation of haplotype effects and haplotype-environment interactions in association studies. Genet Epidemiol 29: 299-312.
25. Loughead J, Wileyto EP, Valdez JN, Sanborn P, Tang K, Strasser AA et al (2009). Effect of abstinence challenge on brain function and cognition in smokers differs by COMT genotype. Mol Psychiatry 14: 820-826.
26. Luo X, Kranzler HR, Zuo L, Yang BZ, Lappalainen J, Gelernter J (2005). ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies. Pharmacogenet Genomics 15: 755-768.
27. Marchant NL, Trawley S, Rusted JM (2008). Prospective memory or prospective attention: physiological and pharmacological support for an attentional model. Int J Neuropsychopharmacol 11: 401-411.
28. McGehee DS (2007). Nicotine and synaptic plasticity in prefrontal cortex. Sci STKE 2007: e44.
29. Monchi O, Petrides M, Petre V, Worsley K, Dagher A (2001). Wisconsin Card Sorting revisited: distinct neural circuits participating in different stages of the task identified by event-related functional magnetic resonance imaging. J Neurosci 21: 7733-7741.
30. Nyholt DR (2004). A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am J Hum Genet 74: 765-769.
31. Pierucci-Lagha A, Gelernter J, Feinn R, Cubells JF, Pearson D, Pollastri A et al (2005). Diagnostic reliability of the semi-structured assessment for drug dependence and alcoholism (SSADDA). Drug Alcohol Depend 80: 303-312.
32. Raimondi E, Rubboli F, Moralli D, Chini B, Fornasari D, Tarroni P et al (1992). Chromosomal localization and physical linkage of the genes encoding the human alpha 3, alpha 5, and beta 4 neuronal nicotinic receptor subunits. Genomics 12: 849-850.
33. Rezvani AH, Levin ED (2001). Cognitive effects of nicotine. Biol Psychiatry 49: 258-267.
34. Robinson AL, Heaton RK, Lehman RA, Stilson DW (1980). The utility of the Wisconsin Card Sorting Test in detecting and localizing frontal lobe lesions. J Consult Clin Psychol 48: 605-614.
35. Saccone SF, Hinrichs AL, Saccone NL, Chase GA, Konvicka K, Madden PA et al (2007). Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Hum Mol Genet 16: 36-49.
36. Sherva R, Kranzler HR, Yu Y, Logue MW, Poling J, Arias AJ et al (2010). Variation in Nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes. Neuropsychopharmacology May 19; e-pub ahead of print. PMID: 20485328.
37. Shi MM, Myrand SP, Bleavins MR, de la Iglesia FA (1999). High throughput genotyping for the detection of a single nucleotide polymorphism in NAD(P)H quinone oxidoreductase (DT diaphor-ase) using TaqMan probes. Mol Pathol 52: 295-299.
38. Thompson JM, Gray JM, Hughes JH, Watson S, Young AH, Ferrier IN (2007). Impaired working memory monitoring in euthymic bipolar patients. Bipolar Disord 9: 478-489.
39. Thorgeirsson TE, Geller F, Sulem P, Rafnar T, Wiste A, Magnusson KP et al (2008). A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature 452: 638-642.
40. Todd RD, Lobos EA, Sun LW, Neuman RJ (2003). Mutational analysis of the nicotinic acetylcholine receptor alpha 4 subunit gene in attention deficit/hyperactivity disorder: evidence for association of an intronic polymorphism with attention problems. Mol Psychiatry 8: 103-108.
41. Wang JC, Grucza R, Cruchaga C, Hinrichs AL, Bertelsen S, Budde JP et al (2009). Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence. Mol Psychiatry 14: 501-510.
42. Weiss RB, Baker TB, Cannon DS, von NA, Dunn DM, Matsunami N et al (2008). A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction. PLoS Genet 4: e1000125.
43. Weiss S, Nosten-Bertrand M, McIntosh JM, Giros B, Martres MP (2007). Nicotine improves cognitive deficits of dopamine transporter knockout mice without long-term tolerance. Neu-ropsychopharmacology 32: 2465-2478.
44. Yang BZ, Zhao H, Kranzler HR, Gelernter J (2005a). Characterization of a likelihood based method and effects of markers informativeness in evaluation of admixture and population group assignment. BMC Genet 6: 50.
45. Yang BZ, Zhao H, Kranzler HR, Gelernter J (2005b). Practical population group assignment with selected informative markers: characteristics and properties of Bayesian clustering via STRUCTURE. Genet Epidemiol 28: 302-312.
46. Zhang H, Kranzler HR, Poling J, Gruen JR, Gelernter J (2009). Cognitive flexibility is associated with KIBRA variant and modulated by recent tobacco use. Neuropsychopharmacology 34: 2508-2516.
47. Zhou FM, Liang Y, Dani JA (2001). Endogenous nicotinic cholinergic activity regulates dopamine release in the striatum. Nat Neurosci 4: 1224-1229.
48. Ziedonis DM, George TP (1997). Schizophrenia and nicotine use: report of a pilot smoking cessation program and review of neurobiological and clinical issues. Schizophr Bull 23: 247-254.