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Volumn 14, Issue 1, 2011, Pages 205-209

Correlation between the SOD-like activity of hexacoordinate iron(II) complexes and their Fe3+/Fe2+ redox potentials

Author keywords

Iron; Isoindoline ligand; Redox chemistry; SOD mimics

Indexed keywords


EID: 78651293080     PISSN: 13877003     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.inoche.2010.10.023     Document Type: Article
Times cited : (27)

References (42)
  • 7
  • 22
    • 78651280552 scopus 로고    scopus 로고
    • note
    • 3), δ/ppm: 8.23 (m, 4H), 7.90 (m, 4H), 7.62 (m, 4H), 4.06 (s, 6H).
  • 28
    • 78651293277 scopus 로고    scopus 로고
    • note
    • 4 (CCDC 756935).
  • 30
    • 78651290014 scopus 로고    scopus 로고
    • note
    • max, nm (logε)] 493 (4.28), 453 (4.49), 389 (4.40), 367 (4.45), 319 (3.29).
  • 33
    • 78651284140 scopus 로고    scopus 로고
    • note
    • 50 values.
  • 34
    • 78651278079 scopus 로고    scopus 로고
    • note
    • In separate test reactions the inhibition of the xanthine/xanthine oxidase system by the iron(II) complexes was excluded. The reduction of NBT by superoxide anion takes place in a one-electron process giving tetrazolinyl radical, that disproportionates to formazan, which gives indicator colour and NBT. Under assay conditions with 1 mM/min superoxide anion production, where the concentration of the complex and NBT is higher than that of the substrate, a mixture of the reduced and oxidised form of the complex is present simultaneously. This way, there is a possibility of cross reaction between the oxidised form of the putative SOD mimic complex, and the tetrazolinyl radical that leads to overestimation of the SOD activity. To elucidate this problem, the SOD-like activity was tested in three cases (1, 2 and 5, Table 4) with cytochrome c indicator, too. No significant difference in the kcat values was found using cytochrome c compared to the results from the NBT assays, therefore the above depicted cross reaction does not interfere with the superoxide scavenging reactions.
  • 40
    • 78651291296 scopus 로고    scopus 로고
    • Originates from the thiocyanate to iron(II) charge transfer band. This ligand was chosen because there is no overlap between the 460 nm band and other absorption bands of 2
    • Originates from the thiocyanate to iron(II) charge transfer band. This ligand was chosen because there is no overlap between the 460 nm band and other absorption bands of 2.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.