Local administration of antibiotics by gentamicin-collagen sponge does not improve wound healing or reduce recurrence rate after pilonidal excision with primary suture: A prospective randomized controlled trial

World Journal of Surgery

Volumn 34, Issue 12, 2010, Pages 3042-3046

  Andersson, Roland E ^a   Lukas, Gudrun ^a   Skullman, Stefan ^a   Hugander, Anders ^a  

^a Department of Surgery ^*  (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; GENTAMICIN;

ARTICLE; DRUG EFFECT; HUMAN; PILONIDAL SINUS; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL (TOPIC); RECURRENT DISEASE; SUTURING METHOD; TOPICAL DRUG ADMINISTRATION; WOUND HEALING;

ADMINISTRATION, TOPICAL; ANTI-BACTERIAL AGENTS; GENTAMICINS; HUMANS; PILONIDAL SINUS; PROSPECTIVE STUDIES; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RECURRENCE; SUTURE TECHNIQUES; WOUND HEALING;

EID: 78651271659     PISSN: 03642313     EISSN: 14322323     Source Type: Journal    
DOI: 10.1007/s00268-010-0763-2     Document Type: Article

References (28)

1. Sondenaa K, Andersen E, Nesvik I, Soreide JA (1995) Patient characteristics and symptoms in chronic pilonidal sinus disease. Int J Colorectal Dis 10:39-42
2. da Silva JH (2000) Pilonidal cyst: cause and treatment. Dis Colon Rectum 43:1146-1156
3. Chintapatla S, Safarani N, Kumar S, Haboubi N (2003) Sacrococcygeal pilonidal sinus: historical review, pathological insight and surgical options. Tech Coloproctol 7:3-8
4. Bascom JU (1983) Pilonidal disease: long-term results of follicle removal. Dis Colon Rectum 26:800-807
5. Al-Khamis A, McCallum I, King PM, Bruce J (2010) Healing by primary versus secondary intention after surgical treatment for pilonidal sinus. Cochrane Database Syst Rev 1:CD006213
6. Petersen S, Koch R, Stelzner S et al (2002) Primary closure techniques in chronic pilonidal sinus: a survey of the results of different surgical approaches. Dis Colon Rectum 45:1458-1467
7. Lord PH, Millar DM (1965) Pilonidal sinus: a simple treatment. Br J Surg 52:298-300
8. Bascom J, Bascom T (2007) Utility of the cleft lift procedure in refractory 8 pilonidal disease. Am J Surg 193:606-609
9. Bascom J (2008) Surgical treatment of pilonidal disease. BMJ 7649:842-843
10. Sondenaa K, Diab R, Nesvik I, Gullaksen FP, Kristiansen RM, Saebo A, Komer H (2002) Influence of failure of primary wound healing on subsequent recurrence of pilonidal sinus. Combined prospective study and randomised controlled trial. Eur J Surg 168:614-618
11. Kronborg O, Christensen K, Zimmermann-Nielsen C (1985) Chronic pilonidal disease: a randomized trial with a complete 3-year follow-up. Br J Surg 72:303-304
12. Lundhus E, Gottrup F (1993) Outcome at three to five years of primary closure of perianal and pilonidal abscess. A randomized, double-blind clinical trial with a complete three-year followup of one compared with four days' treatment with ampicillin and metronidazole. Eur J Surg 159:555-558
13. Chaudhuri A, Bekdash BA, Taylor AL (2006) Single-dose metronidazole vs. 5-day multi-drug antibiotic regimen in excision of pilonidal sinuses with primary closure: a prospective, randomized, double-blinded pilot study. Int J Colorectal Dis 21:688-692
14. Brook I (1989) Microbiology of infected pilonidal sinuses. J Clin Pathol 42:1140-1142
15. Søndenaa K, Nesvik I, Andersen E, Natås O, Søreide JA (1995) Bacteriology and complications of chronic pilonidal sinus treated with excision and primary suture. Int J Colorectal Dis 10: 161-166
16. Jørgensen LG, Sørensen TS, Lorentzen JE (1991) Clinical and pharmacokinetic evaluation of gentamycin containing collagen in groin wound infections after vascular reconstruction. Eur J Vasc Surg 5:87-91
17. Ruszczak Z, Friess W (2003) Collagen as a carrier for on-site delivery of antibacterial drugs. Adv Drug Deliv Rev 55: 1679-1698
18. Musella M, Guido A, Musella S (2001) Collagen tampons as aminoglycoside carriers to reduce postoperative infection rate in prosthetic repair of groin hernias. Eur J Surg 167:130-132
19. Gruessner U, Clemens M, Pahlplatz PV, Sperling P, Witte J, Rosen HR, Septocoll Study Group (2001) Improvement of perineal wound healing by local administration of gentamicinimpregnated collagen fleeces after abdominoperineal excision of rectal cancer. Am J Surg 182:502-509
20. Mortensen J, Kraglund K, Klaerke M, Jaeger G, Svane S, Boné J (1995) Primary suture of anorectal abscess. A randomized study comparing treatment with clindamycin vs. clindamycin and Gentacoll. Dis Colon Rectum 38:398-401
21. Buimer MG, Ankersmit MF, Wobbes T, Klinkenbijl JH (2008) Surgical treatment of hidradenitis suppurativa with gentamicin sulfate: a prospective randomized study. Dermatol Surg 34: 224-227
22. Gustafsson UM, Graf W (2006) Randomized clinical trial of local gentamicin-collagen treatment in advancement flap repair for anal fistula. Br J Surg 93:1202-1207
23. Haase O, Raue W, Böhm B, Neuss H, Scharfenberg M, Schwenk W (2005) Subcutaneous gentamicin implant to reduce wound infections after loop-ileostomy closure: a randomized, doubleblind, placebo-controlled trial. Dis Colon Rectum 48:2025-2031
24. Friberg O (2007) Local collagen-gentamicin for prevention of sternal wound infections: the LOGIP trial. APMIS 115: 1016-1021
25. Eklund AM (2007) Prevention of sternal wound infections with locally administered gentamicin. APMIS 115:1022-1024
26. Holzer B, Grüssner U, Brückner B, Houf M, Kiffner E et al (2003) Efficacy and tolerance of a new gentamicin collagen fleece (Septocoll) after surgical treatment of a pilonidal sinus. Colorectal Dis 5:222-227
27. Rao MM, Zawislak W, Kennedy R, Gilliland R (2010) A prospective randomised study comparing two treatment modalities for chronic pilonidal sinus with a 5-year follow-up. Int J Colorectal Dis 25:395-400
28. Vogel P, Lenz J (1992) Die Behandlung des Sinus pilonidalis mittels Excision und Primarnaht unter Verwendung eines lokalen, resorbierbaren Antibioticumtragers. Ergebnisse einer prospektiven, randomisierten Untersuchung. Chirurg 63:748-753