Single-dose metronidazole vs 5-day multi-drug antibiotic regimen in excision of pilonidal sinuses with primary closure: A prospective, randomized, double-blinded pilot study

International Journal of Colorectal Disease

Volumn 21, Issue 7, 2006, Pages 688-692

  Chaudhuri, A ^a,b   Bekdash, B A ^a   Taylor, A L ^a  

^a HINCHINGBROOKE HOSPITAL   (United Kingdom)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

Antibiotic cover; Infection related wound complications; Pilonidal sinus; Primary closure

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; CEFUROXIME; METRONIDAZOLE;

ABSCESS; ADULT; CLINICAL ARTICLE; CLINICAL FEATURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COST BENEFIT ANALYSIS; DOUBLE BLIND PROCEDURE; DRUG DOSE REGIMEN; FEMALE; FOLLOW UP; HEALTH CARE COST; HUMAN; INFECTION PREVENTION; MALE; PILONIDAL SINUS; PILOT STUDY; POSTOPERATIVE COMPLICATION; POSTOPERATIVE PERIOD; PREOPERATIVE CARE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; REVIEW; SINGLE DRUG DOSE; SKIN REDNESS; SKIN SURGERY; SURGICAL INFECTION; SUTURE; SWELLING; WOUND CLOSURE; WOUND HEALING;

ADULT; ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; MALE; METRONIDAZOLE; PILONIDAL SINUS; PILOT PROJECTS; PROSPECTIVE STUDIES; SURGICAL WOUND INFECTION;

EID: 33749023054     PISSN: 01791958     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00384-005-0064-7     Document Type: Review

References (20)

1. Lamke LO, Larsson J, Nylen B (1974) Results of different types of operation for pilonidal sinus. Acta Chir Scand 140:321-324
2. Spivak H, Brooks PA, Nussbaum M, Friedman I (1996) Treatment of chronic pilonidal disease. Dis Colon Rectum 39(10):1136-1139
3. Allen-Mersh TG (1990) Pilonidal sinus: Finding the right track for treatment. Br J Surg 77(2):123-132
4. Esposito S (1999) Is single shot antibiotic prophylaxis sufficient for any surgical procedure? J Chemother 11(6):556-564
5. Sondenaa K, Nesvik I, Gullaksen FP, Furnes A, Harbo SO, Weyessa S, Soreide JA (1995) The role of cefoxitin prophylaxis in chronic pilonidal sinus treated with excision and primary suture. J Am Coll Surg 180(2):157-160
6. Chaudhuri A, Bekdash BA (2002) Single-dose metronidazole versus 5-day multi-drug antibiotic regimen in excision of pilonidal sinuses with primary closure: A prospective double-blinded randomised controlled study (clinical study protocol). Int J Colorectal Dis 17:355-358
7. Uitenbroek DG (1997) Binomial. SISA. http://home.clara.net/sisa/ binomial.htm. Cited 1 Jan 2002
8. Hodges RM (1880) Pilonidal sinus. Boston Med Surg J 103:485-486
9. Bernhoft WH (1967) Pilonidal disease. A critique on surgical management. Arch Surg 94:418-420
10. Pearson HE, Smiley DF (1968) Bacteroides in pilonidal sinuses. Am J Surg 115:336-338
11. Marks J, Harding KG, Hughes LE, Ribeiro CD (1985) Pilonidal sinus excision-healing by open granulation. Br J Surg 72(8):637-640
12. Bascom JU (1996) Pilonidal care: Anaerobes as invisible villains. Eur J Surg 162
13. Altmeier WA, Burke JF, Pruitt BA Jr, Sandusky WR (eds) (1984) Manual on control of infection in surgical patients, 2nd edn. Lippincott, Philadelphia, p 28
14. Huang T, Cheng TY (2001) The use of a tie-over stent wound suturing technique revisited. Plast Reconstr Surg 108(5):1309-1315
15. Testini M, Piccinni G, Miniello S, Di Venere B, Lissidini G et al (2001) Treatment of chronic pilonidal sinus with local anaesthesia: A randomized trial of closed compared with open technique. Colorectal Dis 3(6):427-430
16. Aldean I, Shankar PJ, Mathew J, Safarani N, Haboubi NY (2005) Simple excision and primary closure of pilonidal sinus: A simple modification of conventional technique with excellent results. Colorectal Dis 7(1):81-85
17. Petersen S, Koch R, Stelzner S, Wendlandt T-P, Ludwig K (2002) Primary closure techniques in chronic pilonidal sinus: A survey of the results of different surgical approaches. Dis Colon Rectum 45(11):1458-1467
18. Dalenback J, Magnusson O, Wedel N, Rimback G (2004) Prospective follow-up after ambulatory plain midline excision of pilonidal sinus and primary suture under local anaesthesia-efficient, sufficient, and persistent. Colorectal Dis 6(6):488-493
19. Naja MZ, Ziade MF, El Rajab M (2003) Sacrococcygeal local anaesthesia versus general anaesthesia for pilonidal sinus surgery: A prospective randomised trial. Anaesthesia 58(10):1007-1012
20. Holzer B, Gruner U, Bruckner B, Houf M, Kiffner E et al (2003) Efficacy and tolerance of a new gentamicin collagen fleece (Septocoll) after surgical treatment of a pilonidal sinus. Colorectal Dis 5(3):222-227