Silicone and autoimmunity

European Journal of Clinical Investigation

Volumn 41, Issue 2, 2011, Pages 203-211

  Hajdu, Steven D ^a   Agmon Levin, Nancy ^a   Shoenfeld, Yehuda ^a,b  

^a SHEBA MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Autoimmune; Breast implants; Cancer; Capsular contracture; Connective tissue disease; Silicone

Indexed keywords

AUTOANTIBODY; BACITRACIN; CEFAZOLIN; GENTAMICIN; SILICONE; ZAFIRLUKAST;

ADVERSE OUTCOME; ALLERGIC REACTION; AUTOIMMUNITY; AUTOINFLAMMATORY DISEASE; BREAST CARCINOGENESIS; BREAST ENDOPROSTHESIS; CANCER RISK; CHRONIC FATIGUE SYNDROME; ENVIRONMENTAL EXPOSURE; ESTHETICS; GENETIC PREDISPOSITION; HUMAN; IMMUNOTOXICITY; IMPLANT CAPSULAR CONTRACTURE; INFLAMMATION; PAIN; PRIORITY JOURNAL; REVIEW; RISK BENEFIT ANALYSIS; RISK FACTOR; SILICONE PROSTHESIS; SILICONOSIS; SYSTEMIC DISEASE; WOUND HEALING;

AUTOIMMUNE DISEASES; BREAST IMPLANTS; BREAST NEOPLASMS; FEMALE; HUMANS; MASTECTOMY; RECONSTRUCTIVE SURGICAL PROCEDURES; RISK FACTORS; SILICONES;

EID: 78651268152     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2010.02389.x     Document Type: Review

References (79)

1. The American Society for Aesthetic Plastic Surgery. National Plastic Surgery Statistics Editor. California: The American Society for Aesthetic Plastic Surgery, 2009.
2. Steenland K. One agent, many diseases: exposure-response data and comparative risks of different outcomes following silica exposure. Am J Ind Med, 2005;48:16-23.
3. Sanchez-Guerrero J, Colditz GA, Karlson EW, Hunter DJ, Speizer FE, Liang MH. Silicone breast implants and the risk of connective-tissue diseases and symptoms. N Engl J Med, 1995;332:1666-70.
4. Vasey FB, Zarabadi SA, Seleznick M, Ricca L. Where there's smoke there's fire: the silicone breast implant controversy continues to flicker: a new disease that needs to be defined. J Rheumatol, 2003;30:2092-4.
5. Gabriel SE, O'Fallon WM, Kurland LT, Beard CM, Woods JE, Melton LJ 3rd. Risk of connective-tissue diseases and other disorders after breast implantation. N Engl J Med, 1994;330:1697-702.
6. Miyoshi K, Miyamura T, Kobayashi Y, Itakura T, Nishijo K. Hypergammaglobulinemia by prolonged adjuvanticity in man: disorders developed after augmentation mamaplasty. Jpn Med J, 1964;2122:9-14.
7. Uretsky BF, O'Brien JJ, Courtiss EH, Becker MD. Augmentation mammaplasty associated with a severe systemic illness. Ann Plast Surg, 1979;3:445-7.
8. Endo LP, Edwards NL, Longley S, Corman LC, Panush RS. Silicone and rheumatic diseases. Semin Arthritis Rheum, 1987;17:112-8.
9. Sergott TJ, Limoli JP, Baldwin CM Jr, Laub DR. Human adjuvant disease, possible autoimmune disease after silicone implantation: a review of the literature, case studies, and speculation for the future. Plast Reconstr Surg, 1986;78:104-14.
10. Kessler DA. The basis of the FDA's decision on breast implants. N Engl J Med, 1992;326:1713-5.
11. Hennekens CH, Lee IM, Cook NR, Hebert PR, Karlson EW, LaMotte F. Self-reported breast implants and connective-tissue diseases in female health professionals. A retrospective cohort study. JAMA, 1996;275:616-21.
12. Young VL, Nemecek JR, Nemecek DA. The efficacy of breast augmentation: breast size increase, patient satisfaction, and psychological effects. Plast Reconstr Surg, 1994;94:958-69.
13. Cunningham BL, Lokeh A, Gutowski KA. Saline-filled breast implant safety and efficacy: a multicenter retrospective review. Plast Reconstr Surg, 2000;105:2143-9. discussion 2150-1.
14. Cunningham B, McCue J. Safety and effectiveness of Mentor's MemoryGel implants at 6 years. Aesthetic Plast Surg, 2009;33:440-4.
15. Prantl L, Poppl N, Horvat N, Heine N, Eisenmann-Klein M. Serologic and histologic findings in patients with capsular contracture after breast augmentation with smooth silicone gel implants: is serum hyaluronan a potential predictor? Aesthetic Plast Surg, 2005;29:510-8.
16. Prantl L, Angele P, Schreml S, Ulrich D, Poppl N, Eisenmann-Klein M. Determination of serum fibrosis indexes in patients with capsular contracture after augmentation with smooth silicone gel implants. Plast Reconstr Surg, 2006;118:224-9.
17. Wolfram D, Oberreiter B, Mayerl C, Soelder E, Ulmer H, Piza-Katzer H. Altered systemic serologic parameters in patients with silicone mammary implants. Immunol Lett, 2008;118:96-100.
18. Gayou R, Rudolph R. Capsular contraction around silicone mammary prostheses. Ann Plast Surg, 1979;2:62-71.
19. Gylbert L, Asplund O, Jurell G. Capsular contracture after breast reconstruction with silicone-gel and saline-filled implants: a 6-year follow-up. Plast Reconstr Surg, 1990;85:373-7.
20. Hölmich LR, Kjøller K, Fryzek JP, Høier-Madsen M, Vejborg I, Conrad C. Self-reported diseases and symptoms by rupture status among unselected Danish women with cosmetic silicone breast implants. Plast Reconstr Surg, 2003;111:723-32. discussion 733-4.
21. Netscher DT. Subclinical infection in breast capsules. Plast Reconstr Surg, 2004;114:818-20.
22. Pajkos A, Deva AK, Vickery K, Cope C, Chang L, Cossart YE. Detection of subclinical infection in significant breast implant capsules. Plast Reconstr Surg, 2003;111:1605-11.
23. Burkhardt BR. Capsular contracture: hard breasts, soft data. Clin Plast Surg, 1988;15:521-32.
24. Mastruserio DN, Pesqueira MJ, Cobb MW Severe granulomatous reaction and facial ulceration occurring after subcutaneous silicone injection. J Am Acad Dermatol 1996; 34 (5 Pt 1): 849-52.
25. Rapaport MJ, Vinnik C, Zarem H. Injectable silicone: cause of facial nodules, cellulitis, ulceration, and migration. Aesthetic Plast Surg, 1996;20:267-76.
26. Teuber SS, Ito LK, Anderson M, Gershwin ME. Silicone breast implant-associated scarring dystrophy of the arm. Arch Dermatol, 1995;131:54-6.
27. Marcusson JA, Bjarnason B. Unusual skin reaction to silicone content in breast implants. Acta Derm Venereol, 1999;79:136-8.
28. Maharaj SV. Platinum concentration in silicone breast implant material and capsular tissue by ICP-MS. Anal Bioanal Chem, 2004;380:84-9.
29. Flassbeck D, Pfleiderer B, Klemens P, Heumann KG, Eltze E, Hirner AV. Determination of siloxanes, silicon, and platinum in tissues of women with silicone gel-filled implants. Anal Bioanal Chem, 2003;375:356-62.
30. Cantisani C, Cigna E, Grieco T, Miller DM, De Gado F, Calvieri S. Allergic contact dermatitis to synthetic rubber following breast augmentation. Eur Ann Allergy Clin Immunol, 2007;39:185-8.
31. Oprea ML, Schnoring H, Sachweh JS, Ott H, Biertz J, Vazquez-Jimenez JF. Allergy to pacemaker silicone compounds: recognition and surgical management. Ann Thorac Surg, 2009;87:1275-7.
32. Watsky KL. Occupational allergic contact dermatitis to platinum, palladium, and gold. Contact Derm, 2007;57:382-3.
33. Santucci B, Valenzano C, de Rocco M, Cristaudo A. Platinum in the environment: frequency of reactions to platinum-group elements in patients with dermatitis and urticaria. Contact Derm, 2000;43:333-8.
34. Brown SL, Middleton MS, Berg WA, Soo MS, Pennello G. Prevalence of rupture of silicone gel breast implants revealed on MR imaging in a population of women in Birmingham, Alabama. AJR Am J Roentgenol, 2000;175:1057-64.
35. Brinton LA. The relationship of silicone breast implants and cancer at other sites. Plast Reconstr Surg, 2007;120(7 Suppl 1):94S-102S.
36. Brinton LA, Lubin JH, Burich MC, Colton T, Hoover RN. Mortality among augmentation mammoplasty patients. Epidemiology, 2001;12:321-6.
37. Asplund O. Capsular contracture in silicone gel and saline-filled breast implants after reconstruction. Plast Reconstr Surg, 1984;73:270-5.
38. Vermeulen RC, Scholte HR. Rupture of silicone gel breast implants and symptoms of pain and fatigue. J Rheumatol, 2003;30:2263-7.
39. Brown SL, Pennello G, Berg WA, Soo MS, Middleton MS. Silicone gel breast implant rupture, extracapsular silicone, and health status in a population of women. J Rheumatol, 2001;28:996-1003.
40. Hedén P, Bronz G, Elberg JJ, Deraemaecker R, Murphy DK, Slicton A. Long-term safety and effectiveness of style 410 highly cohesive silicone breast implants. Aesthetic Plast Surg, 2009;33:430-6. discussion 437-8.
41. Goldblum RM, Pelley RP, O'Donell AA, Pyron D, Heggers JP. Antibodies to silicone elastomers and reactions to ventriculoperitoneal shunts. Lancet, 1992;340:510-3.
42. Bekerecioglu M, Onat AM, Tercan M, Buyukhatipoglu H, Karakok M, Isik D. The association between silicone implants and both antibodies and autoimmune diseases. Clin Rheumatol, 2008;27:147-50.
43. Evans GR, Slezak S, Rieters M, Bercowy GM. Silicon tissue assays in nonaugmented cadaveric patients: is there a baseline level? Plast Reconstr Surg, 1994;93:1117-22.
44. Levy Y, Rotman-Pikielny P, Ehrenfeld M, Shoenfeld Y. Silicone breast implantation-induced scleroderma: description of four patients and a critical review of the literature. Lupus, 2009;18:1226-32.
45. Wolf LE, Lappe M, Peterson RD, Ezrailson EG. Human immune response to polydimethylsiloxane (silicone): screening studies in a breast implant population. FASEB J, 1993;7:1265-8.
46. Karlson EW, Hankinson SE, Liang MH, Sanchez-Guerrero J, Colditz GA, Rosenau BJ. Association of silicone breast implants with immunologic abnormalities: a prospective study. Am J Med, 1999;106:11-9.
47. White KL Jr, Klykken PC. The non-specific binding of immunoglobulins to silicone implant materials: the lack of a detectable silicone specific antibody. Immunol Invest, 1998;27:221-35.
48. Schaefer CJ, Wooley PH. The influence of silicone implantation on murine lupus in MRL lpr/lpr mice. J Rheumatol, 1999;26:2215-21.
49. Zandman-Goddard G, Blank M, Ehrenfeld M, Gilburd B, Peter J, Shoenfeld Y. A comparison of autoantibody production in asymptomatic and symptomatic women with silicone breast implants. J Rheumatol, 1999;26:73-7.
50. Breiting VB, Hölmich LR, Brandt B, Fryzek JP, Wolthers MS, Kjøller K. Long-term health status of Danish women with silicone breast implants. Plast Reconstr Surg, 2004;114:217-26. discussion 227-8.
51. Bar-Meir E, Eherenfeld M, Shoenfeld Y. Silicone gel breast implants and connective tissue disease - a comprehensive review. Autoimmunity, 2003;36:193-7.
52. Teuber SS, Rowley MJ, Yoshida SH, Ansari AA, Gershwin ME. Anti-collagen autoantibodies are found in women with silicone breast implants. J Autoimmun, 1993;6:367-77.
53. Karlson EW, Lee IM, Cook NR, Buring JE, Hennekens CH, Bloch KJ. Serologic evaluations of women exposed to breast implants. J Rheumatol, 2001;28:1523-30.
54. Peters W, Keystone E, Snow K, Rubin L, Smith D. Is there a relationship between autoantibodies and silicone-gel implants? Ann Plast Surg, 1994;32:1-5. discussion 5-7.
55. Bondurant S, Ernster VL, Herdman R. Safety of Silicone Breast Implants. Committee on the Safety of Silicone Breast Implants, Division of Health Promotion and Disease Prevention, Institute of Medicine. Washington, DC: National Academy Press; 2000.
56. Kumagai Y, Shiokawa Y, Medsger TA Jr, Rodnan GP. Clinical spectrum of connective tissue disease after cosmetic surgery. Observations on eighteen patients and a review of the Japanese literature. Arthritis Rheum, 1984;27:1-12.
57. van Nunen SA, Gatenby PA, Basten A. Post-mammoplasty connective tissue disease. Arthritis Rheum, 1982;25:694-7.
58. Spiera RF, Gibofsky A, Spiera H. Silicone gel filled breast implants and connective tissue disease: an overview. J Rheumatol, 1994;21:239-45.
59. Janowsky EC, Kupper LL, Hulka BS. Meta-analyses of the relation between silicone breast implants and the risk of connective-tissue diseases. N Engl J Med, 2000;342:781-90.
60. Diamond BAH, Kerkvliet BS, Tugwell NIP. Silicone breast implants in relation to connective tissue diseases and immunologic dysfunction: a report by a National Science Panel to the Hon. Sam C. Pointer Jr. National Science Panel. Chapter IV-7, 1998.
61. Fryzek JP, Signorello LB, Hakelius L, Feltelius N, Ringberg A, Blot WJ. Self-reported symptoms among women after cosmetic breast implant and breast reduction surgery. Plast Reconstr Surg, 2001;107:206-13.
62. Cuellar ML, Espinoza LR. Silicone breast implants and connective tissue disease. J Rheumatol, 1994;21:1979-80.
63. Agmon-Levin N, Shoenfeld Y. Chronic fatigue syndrome with autoantibodies - the result of an augmented adjuvant effect of hepatitis-B vaccine and silicone implant. Autoimmun Rev, 2008;8:52-5.
64. Holmich LR, Lipworth L, McLaughlin JK, Friis. S. Breast implant rupture and connective tissue disease: a review of the literature. Plast Reconstr Surg, 2007;7(Suppl 1):62S-9S.
65. Shoenfeld Y, Agmon-Levin N. 'ASIA'- Autoimmune (Auto-inflammatory) Syndrome induced by Adjuvant: a new syndrome to be defined. J Autoimmun, 2010; Aug 12 [Epub ahead of print].
66. Shoenfeld Y et al. The mosaic of autoimmunity: prediction, autoantibodies, and therapy in autoimmune diseases--2008. Isr Med Assoc J, 2008;10:13-9.
67. Shoenfeld Y, Gilburd B, Abu-Shakra M, Amital H, Barzilai O, Berkun Y. The mosaic of autoimmunity: genetic factors involved in autoimmune diseases--2008. Isr Med Assoc J, 2008;10:3-7.
68. Young VL, Nemecek JR, Schwartz BD, Phelan DL, Schorr MW. HLA typing in women with breast implants. Plast Reconstr Surg, 1995;96:1497-519. discussion 1520.
69. Israeli E, Agmon-Levin N, Blank M, Shoenfeld Y. Adjuvants and autoimmunity. Lupus, 2009;18:1217-25.
70. Wise DL Biomaterials Engineering and Devices. Totowa, NJ: Humana Press; 2000.
71. Vazquez G, Pellon A. Polyurethane-coated silicone gel breast implants used for 18 years. Aesthetic Plast Surg, 2007;31:330-6.
72. Sinclair TM, Kerrigan CL, Buntic R. Biodegradation of the polyurethane foam covering of breast implants. Plast Reconstr Surg, 1993;92:1003-13. discussion 1014.
73. Wong CH, Samuel M, Tan BK, Song C. Capsular contracture in subglandular breast augmentation with textured versus smooth breast implants: a systematic review. Plast Reconstr Surg, 2006;118:1224-36.
74. Bastos EM, Neto MS, Alves MT, Garcia EB, Santos RA, Heink T. Histologic analysis of zafirlukast's effect on capsule formation around silicone implants. Aesthetic Plast Surg, 2007;31:559-65.
75. Scuderi N, Mazzocchi M, Rubino C. Effects of zafirlukast on capsular contracture: controlled study measuring the mammary compliance. Int J Immunopathol Pharmacol, 2007;20:577-84.
76. Adams WP Jr, Rios JL, Smith SJ. Enhancing patient outcomes in aesthetic and reconstructive breast surgery using triple antibiotic breast irrigation: six-year prospective clinical study. Plast Reconstr Surg, 2006;118(7 Suppl):46S-52S.
77. Vasey FB, Havice DL, Bocanegra TS, Seleznick MJ, Bridgeford PH, Martinez-Osuna P. Clinical findings in symptomatic women with silicone breast implants. Semin Arthritis Rheum, 1994;24(1 Suppl 1):22-8.
78. Rohrich RJ, Rathakrishnan R, Robinson JB Jr, Griffin JR. Factors predictive of quality of life after silicone-implant explanation. Plast Reconstr Surg, 1999;104:1334-7.
79. The American Society for Aesthetic Plastic Surgery. Cosmetic Surgery National Data Bank Statistics. California: The American Society for Aesthetic Plastic Surgery; 2008.