8-Aza-7,9-dideazaxanthine acyclic nucleoside phosphonate inhibitors of thymidine phosphorylase

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 2, 2011, Pages 652-654

  Mařák, David ^a   Otmar, Miroslav ^a   Votruba, Ivan ^a   Dračínský, Martin ^a   Krečmerová, Marcela ^a  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

Author keywords

8 Aza 7,9 dideazaxanthine; Nucleotide analog; Pyrrolo 3,4 d pyrimidine

Indexed keywords

3 (8 PHOSPHONOOCTYL) 8 AZA 7,9 DIDEAZAXANTHINE; 8 (8 PHOSPHONOOCTYL) 8 AZA 7,9 DIDEAZAXANTHINE; 8 AZA 7,9 DIDEAZAXANTHINE ACYCLIC NUCLEOSIDE PHOSPHONATE INHIBITOR; NUCLEOSIDE ANALOG; THYMIDINE PHOSPHORYLASE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; ESCHERICHIA COLI; HUMAN; IC 50; NONHUMAN; PLACENTA; STRUCTURE ACTIVITY RELATION;

ENZYME INHIBITORS; ESCHERICHIA COLI; FEMALE; HUMANS; PLACENTA; PREGNANCY; PYRIMIDINONES; PYRROLES; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; THYMIDINE PHOSPHORYLASE;

ESCHERICHIA COLI;

EID: 78651258566     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.12.027     Document Type: Article

References (7)

1. A.L. Allan, P.L. Gladstone, M.L.P. Price, S.A. Hopkins, J.C. Juarez, F. Doñate, R.J. Ternansky, D.E. Shaw, B. Ganem, Y. Li, W. Wang, and S. Ealick J. Med. Chem. 49 2006 7807
2. A. Esteban-Gamboa, J. Balzarini, R. Esnouf, E. De Clercq, M.-J. Camarasa, and M.-J. Pérez-Pérez J. Med. Chem. 43 2000 971
3. D. Mařák, M. Otmar, M. Dračínský, I. Votruba, and A. Holý M. Hocek, Collection Symposium Series Vol. 10 2008 Institute of Organic Chemistry and Biochemistry, v.v.i., Academy of Sciences of the Czech Republic Prague 426 428
4. M.N. Zimmerman, N.H. Nemeroff, C.W. Bock, and K.L. Bhat Heterocycles 53 2000 205
5. 5P (M+H): 344.1375, found: 344.1375.
6. N.G. Kudu, and S.G. Khatri Synthesis 1985 323
7. A. Yoshimura, Y. Kuwazuru, T. Furukawa, H. Yoshida, K. Yamada, and S. Akiyama Biochim. Biophys. Acta 1013 1990 107