The decrease of serum levels of human neutrophil alpha-defensins parallels with the surgery-induced amelioration of NASH in obesity

Obesity Surgery

Volumn 20, Issue 12, 2010, Pages 1682-1689

  Manco, Melania ^a   Fernandez Real, José Manuel ^b   Vecchio, Fabio Maria ^c   Vellone, Valerio ^c   Moreno, José María ^b   Tondolo, Vincenzo ^d   Bottazzo, Gianfranco ^a   Nanni, Giuseppe ^d   Mingrone, Geltrude ^c  

^a BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^b HOSPITAL JOSEP TRUETA   (Spain)

^c CATHOLIC UNIVERSITY   (Italy)

^d CATHOLIC UNIVERSITY   (Italy)

Author keywords

Bariatric surgery; Human neutrophil alpha defensins (HNDs); Inflammation; Innate immune system; Insulin sensitivity; Non alcoholic fatty liver disease (NAFLD); Non alcoholic steatohepatitis (NASH); Obesity; Soluble CD14 receptor (sCD14)

Indexed keywords

ALPHA DEFENSIN; CD14 ANTIGEN RECEPTOR; LYMPHOCYTE ANTIGEN RECEPTOR; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BODY MASS; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; FEMALE; GLUCOSE TRANSPORT; HUMAN; INFLAMMATION; LIVER BIOPSY; NEUTROPHIL; NONALCOHOLIC FATTY LIVER; OBESITY; POSTOPERATIVE PERIOD; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SCORING SYSTEM; WEIGHT REDUCTION;

ADULT; ALPHA-DEFENSINS; ANTIGENS, CD14; BILIOPANCREATIC DIVERSION; BIOLOGICAL MARKERS; BODY MASS INDEX; FATTY LIVER; FEMALE; HUMANS; INFLAMMATION; INSULIN RESISTANCE; OBESITY, MORBID; WEIGHT LOSS; YOUNG ADULT;

EID: 78651240051     PISSN: 09608923     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11695-010-0129-8     Document Type: Article

References (51)

1. PA Tataranni E Ortega 2005 A burning question: does an adipokine-induced activation of the immune system mediate the effect of overnutrition on type 2 diabetes? Diabetes 54 917 927 1:CAS:528:DC%2BD2MXjtFWntrY%3D 10.2337/diabetes.54.4.917 15793228 (Pubitemid 40446304)
2. JJ Maher P Leon JC Ryan 2008 Beyond insulin resistance: innate immunity in NASH Hepatology 48 670 678 1:CAS:528:DC%2BD1cXhtVCqt7nK 10.1002/hep.22399 18666225
3. B Gao WI Jeong Z Tian 2008 Liver: an organ with predominant innate immunity Hepatology 47 729 736 1:CAS:528:DC%2BD1cXitF2ksr0%3D 10.1002/hep.22034 18167066 (Pubitemid 351280741)
4. JM Fernandez-Real M Broch C Richart, et al. 2003 CD14 monocyte receptor, involved in the inflammatory cascade, and insulin sensitivity J Clin Endocrinol Metab 88 1780 1784 1:CAS:528:DC%2BD3sXjtFClt7w%3D 10.1210/jc.2002-020173 12679473 (Pubitemid 36623404)
5. JM Fernández-Real A López-Bermejo M Broch, et al. 2004 Circulating soluble CD14 monocyte receptor is associated with increased alanine aminotransferase Clin Chem 50 1456 1458 10.1373/clinchem.2003.030015 15277359 (Pubitemid 38970666)
6. C Fearns DJ Loskutoff 1997 Role of tumor necrosis factor α in induction of murine CD14 gene expression by lipopolysaccharide Infect Immun 65 4822 4831 1:CAS:528:DyaK2sXntlWis7s%3D 9353071
7. JY Lee DH Hwang 2006 The modulation of inflammatory gene expression by lipids: mediation through Toll-like receptors Mol Cells 21 174 185 1:CAS:528:DC%2BD28Xlt1Wjsrw%3D 16682810
8. M Manco JM Fernandez-Real F Equitani, et al. 2007 Effect of massive weight loss on inflammatory adipocytokines and the innate immune system in morbidly obese women J Clin Endocrinol Metab 92 483 490 1:CAS:528: DC%2BD2sXitVaksL0%3D 10.1210/jc.2006-0960 17105839
9. ME Klotman TL Chang 2006 Defensins in innate antiviral immunity Nat Rev Immunol 6 447 456 1:CAS:528:DC%2BD28XkvVyrtrk%3D 10.1038/nri1860 16724099
10. J Grigat A Soruri U Forssmann, et al. 2007 Chemoattraction of macrophages, T lymphocytes, and mast cells is evolutionarily conserved within the human alpha-defensin family J Immunol 179 3958 3965 1:CAS:528: DC%2BD2sXpvFKlt78%3D 17785833
11. D Yang A Biragyn LW Kwak, et al. 2002 Mammalian defensins in immunity: more than just microbicidal Trends Immunol 23 291 296 1:CAS:528: DC%2BD38XksF2hu7s%3D 10.1016/S1471-4906(02)02246-9 12072367 (Pubitemid 34628771)
12. HY Liu QF Collins F Moukdar, et al. 2008 Suppression of hepatic glucose production by human neutrophil alpha-defensins through a signaling pathway distinct from insulin J Biol Chem 283 18 12056 12063 1:CAS:528: DC%2BD1cXltVyrsL0%3D 10.1074/jbc.M801033200 18347011
13. H Nassar E Lavi S Akkawi, et al. 2007 alpha-Defensin: link between inflammation and atherosclerosis Atherosclerosis 194 452 457 1:CAS:528:DC%2BD2sXhtFerurbF 10.1016/j.atherosclerosis.2006.08.046 16989837 (Pubitemid 47513077)
14. G Joseph L Tarnow AS Astrup, et al. 2008 Plasma {alpha}-defensin is associated with cardiovascular morbidity and mortality in type 1 diabetic patients J Clin Endocrinol Metab 93 1470 1475 1:CAS:528:DC%2BD1cXks1agsLs%3D 10.1210/jc.2007-1910 18211979 (Pubitemid 351519750)
15. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus 2003 Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus Diabetes Care 26 S5 S20 10.2337/diacare.26.11.3160 (Pubitemid 37339514)
16. Consensus Conference 1985 Lowering blood cholesterol to prevent heart disease JAMA 253 2080 2086 10.1001/jama.253.14.2080 (Pubitemid 15102224)
17. N Scopinaro E Gianetta D Civalleri, et al. 1979 Bilio-pancreatic bypass for obesity: II. Initial experience in man Br J Surg 66 618 620 1:STN:280:DyaL3c%2Fktlyqsw%3D%3D 10.1002/bjs.1800660906 497645 (Pubitemid 10224288)
18. SB Heymsfield S Lichtman RN Baumgartner, et al. 1990 Body composition of humans: comparison of two improved four-compartment models that differ in expense, technical complexity, and radiation exposure Am J Clin Nutr 52 52 58 1:STN:280:DyaK3c3pslSlug%3D%3D 2360552
19. RA DeFronzo JD Tobin R Andres 1979 Glucose clamp technique: a method for quantifying insulin secretion and resistance Am J Physiol 237 E214 E223 1:CAS:528:DyaE1MXlslWhs70%3D 382871
20. DE Kleiner EM Brunt M Van Natta, et al. 2005 Nonalcoholic steatohepatitis clinical research network. Design and validation of a histological scoring system for nonalcoholic fatty liver disease Hepatology 41 1313 1321 10.1002/hep.20701 15915461 (Pubitemid 40770284)
21. JR Landis GG Koch 1977 An application of hierarchical kappa-type statistics in the assessment of majority agreement among multiple observers Biometrics 33 363 374 1:STN:280:DyaE2s3it1ansA%3D%3D 10.2307/2529786 884196
22. AA Higazi E Lavi K Bdeir, et al. 1997 Defensin stimulates the binding of lipoprotein(a) to human vascular endothelial and smooth muscle cells Blood 89 4290 4298 1:CAS:528:DyaK2sXjvFCnt74%3D 9192751
23. A López-Bermejo B Chico-Julià A Castro, et al. 2007 Alpha defensins 1, 2, and 3: potential roles in dyslipidemia and vascular dysfunction in humans Arterioscler Thromb Vasc Biol 27 1166 1171 10.1161/ATVBAHA.106.138594 17303777 (Pubitemid 46641973)
24. K Bdeir W Cane G Canziani, et al. 1999 Defensin promotes the binding of lipoprotein(a) to vascular matrix Blood 94 2007 2019 1:CAS:528: DyaK1MXlvFCmsr8%3D 10477730
25. G Targer G Arcaro 2007 Non-alcoholic fatty liver disease and increased risk of cardiovascular disease Atherosclerosis 191 235 240 10.1016/j. atherosclerosis.2006.08.021 (Pubitemid 46400718)
26. CP Day OF James 1998 Steatohepatitis: a tale of two "hits"? Gastroenterology 114 842 845 1:STN:280:DyaK1c3htFartQ%3D%3D 10.1016/S0016- 5085(98)70599-2 9547102 (Pubitemid 28160420)
27. IJ Kullo DD Hensrud TG Allison 2002 Comparison of numbers of circulating blood monocytes in men grouped by body mass index (<25, 25 to <30, > or =30) Am J Cardiol 89 1441 1443 10.1016/S0002-9149(02)02366-4 12062747 (Pubitemid 34607793)
28. MS Elkind J Cheng B Boden-Albala, et al. 2001 Elevated white blood cell count and carotid plaque thickness: the Northern Manhattan Stroke Study Stroke 32 842 849 1:STN:280:DC%2BD3M3ivVykug%3D%3D 11283380
29. A Veronelli M Laneri R Ranieri, et al. 2004 White blood cells in obesity and diabetes: effects of weight loss and normalization of glucose metabolism Diabetes Care 27 2501 2502 10.2337/diacare.27.10.2501 15451926 (Pubitemid 39281411)
30. SD Wright RA Ramos PS Tobias, et al. 1990 CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein Science 249 1431 1433 1:CAS:528:DyaK3MXksV2q 10.1126/science.1698311 1698311
31. HW Harris C Grunfeld KR Feingold, et al. 1990 Human very low density lipoproteins and chylomicrons can protect against endotoxin-induced death in mice J Clin Invest 86 696 702 1:CAS:528:DyaK3cXlvVKgtLY%3D 10.1172/JCI114765 2394827
32. M Manco M Marcellini R Devito, et al. 2008 Waist circumference correlates with liver fibrosis in children with non alcoholic steatohepatitis Gut 57 1283 1287 1:CAS:528:DC%2BD1cXhtFKisr7L 10.1136/gut.2007.142919 18218674
33. PD Cani J Amar MA Iglesias, et al. 2007 Metabolic endotoxemia initiates obesity and insulin resistance Diabetes 56 1761 1772 1:CAS:528: DC%2BD2sXnvVWjurk%3D 10.2337/db06-1491 17456850 (Pubitemid 47025442)
34. JY Lee L Zhao DH Hwang 2010 Modulation of pattern recognition receptor-mediated inflammation and risk of chronic diseases by dietary fatty acids Nutr Rev 68 38 61 10.1111/j.1753-4887.2009.00259.x 20041999
35. E Ferrannini S Camastra Gastaldelli, et al. 2004 Beta-cell function in obesity: effects of weight loss Diabetes 53 S26 S33 1:CAS:528:DC%2BD2cXhtVOls7zL 10.2337/diabetes.53.suppl-3.S26 15561918
36. E Ferrannini G Mingrone 2009 Impact of different bariatric surgical procedures on insulin action and beta-cell function in type 2 diabetes Diabetes Care 32 514 520 10.2337/dc08-1762 19246589
37. F Backhed H Ding T Wang, et al. 2004 The gut microbiota as an environmental factor that regulates fat storage Proc Natl Acad Sci USA 101 15718 15723 10.1073/pnas.0407076101 15505215 (Pubitemid 39473554)
38. CJ Wiedermann S Kiechl S Dunzendorfer, et al. 1999 Association of endotoxemia with carotid atherosclerosis and cardiovascular disease: prospective results from the Bruneck Study J Am Coll Cardiol 34 1975 1981 1:STN:280:DC%2BD3c%2FltlCgsQ%3D%3D 10.1016/S0735-1097(99)00448-9 10588212 (Pubitemid 30002653)
39. A Parlesak C Schafer T Schutz, et al. 2000 Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease J Hepatol 32 742 747 1:CAS:528:DC%2BD3cXjslSktbk%3D 10.1016/S0168-8278(00)80242-1 10845660 (Pubitemid 30262733)
40. S Thuy R Ladurner V Volynets, et al. 2008 Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake J Nutr 138 1452 1455 1:CAS:528:DC%2BD1cXovFWns7c%3D 18641190
41. S Camastra M Manco A Mari, et al. 2005 Beta-cell function in morbidly obese subjects during free living: long-term effects of weight loss Diabetes 54 2382 2389 1:CAS:528:DC%2BD2MXnt1yntrk%3D 10.2337/diabetes.54.8.2382 16046305 (Pubitemid 41134266)
42. G Mingrone M Manco L Granato, et al. 2005 Leptin pulsatility in formerly obese women FASEB J 19 1380 1382 1:CAS:528:DC%2BD2MXntlaqt7o%3D 15955844
43. SS Martin A Qasim MP Reilly 2008 Leptin resistance: a possible interface of inflammation and metabolism in obesity-related cardiovascular disease J Am Coll Cardiol 52 1201 1210 1:CAS:528:DC%2BD1cXhtF2rtr%2FL 10.1016/j.jacc.2008.05. 060 18926322
44. M Machado P Marques-Vidal H Cortez-Pinto 2006 Hepatic histology in obese patients undergoing bariatric surgery J Hepatol 45 600 606 10.1016/j.jhep.2006. 06.013 16899321 (Pubitemid 44307393)
45. P Angulo 2006 NAFLD, obesity, and bariatric surgery Gastroenterology 130 1848 1852 10.1053/j.gastro.2006.03.041 16697746 (Pubitemid 43668867)
46. FH Luyckx C Desaive A Thiry, et al. 1998 Liver abnormalities in severely obese subjects: effect of drastic weight loss after gastroplasty Int J Obes Relat Metab Disord 22 222 226 1:STN:280:DyaK1c7pvVGqsQ%3D%3D 10.1038/sj.ijo.0800571 9539189
47. JG Kral SN Thung S Biron, et al. 2004 Effects of surgical treatment of the metabolic syndrome on liver fibrosis and cirrhosis Surgery 135 48 58 10.1016/j.surg.2003.10.003 14694300 (Pubitemid 38041453)
48. JB Dixon PS Bhathal NR Hughes, et al. 2004 Nonalcoholic fatty liver disease: improvement in liver histological analysis with weight loss Hepatology 39 1647 1654 10.1002/hep.20251 15185306 (Pubitemid 38702666)
49. EM Silverman JA Sapala HD Appelman 1995 Regression of hepatic steatosis in morbidly obese persons after gastric bypass Am J Clin Pathol 104 23 31 1:STN:280:DyaK2MzjsFGmtA%3D%3D 7611176
50. S Klein B Mittendorfer JC Eagon, et al. 2006 Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease Gastroenterology 130 1564 1572 1:CAS:528:DC%2BD28Xls1Wisbs%3D 10.1053/j.gastro.2006.01.042 16697719 (Pubitemid 43668832)
51. P Mathurin F Gonzalez O Kerdraon, et al. 2006 The evolution of severe steatosis after bariatric surgery is related to insulin resistance Gastroenterology 130 1617 1624 10.1053/j.gastro.2006.02.024 16697725 (Pubitemid 43668847)