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Volumn 21, Issue 2, 2011, Pages 861-864

Discovery of a series of potent arylthiadiazole H 3 antagonists

Author keywords

H 3 antagonists; SAR study

Indexed keywords

CYTOCHROME P450; HISTAMINE H3 RECEPTOR ANTAGONIST; THIADIAZOLE DERIVATIVE;

EID: 78651232814     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.11.065     Document Type: Article
Times cited : (10)

References (30)
  • 28
    • 78651240360 scopus 로고    scopus 로고
    • note
    • i values were the average of at least two independent determinations. The assay-to-assay variation was generally ±2-fold.
  • 30
    • 78651238960 scopus 로고    scopus 로고
    • note
    • 3H N-α- methylhistamine and 10 μM thioperamide for non-specific binding or assay buffer for total binding. Incubations were performed in quadruplet and stopped by rapid filtration on a Brandel Harvester using Unifilter-96, GF/B plates presoaked in 0.3% PEI for 30 min. The remining radioactivity was measured on a Packard TopCount-NTX. Specific binding was calculated by subtracting the non-specific binding from the total.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.