Can Bcl-XL expression predict the radio sensitivity of Bilharzial-related squamous bladder carcinoma? a prospective comparative study

BMC Cancer

Volumn 11, Issue , 2011, Pages

  Abdel Raheem, Ahmad M ^a   Hameed, Diaa A ^a   ElGanainy, Ehab O ^a   Mosad, Eman ^a   Abdelwanis, Mostafa E ^b   Kamel, Nermen A ^c   Hammouda, Hisham M ^a   Abdelaziz, Mohammad A ^a   Hemeyda, Khaled ^a  

^a Assiut University Faculty of Medicine   (Egypt)

^b ASSIUT UNIVERSITY   (Egypt)

^c Assiut University   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BCL XL; BCL2L1 PROTEIN, HUMAN; PROTEIN BCL X;

ADULT; ARTICLE; BLADDER CARCINOMA; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURVIVAL; CONTROLLED CLINICAL TRIAL; CYSTECTOMY; DIARRHEA; DISEASE FREE SURVIVAL; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PREDICTION; PROSPECTIVE STUDY; PROTEIN EXPRESSION; RADIATION RESPONSE; RADIOSENSITIVITY; SCHISTOSOMA; SQUAMOUS CELL CARCINOMA; TUMOR RECURRENCE; ADJUVANT THERAPY; ANIMAL; BIOSYNTHESIS; BLADDER TUMOR; CLINICAL TRIAL; COMPARATIVE STUDY; KAPLAN MEIER METHOD; METABOLISM; MIDDLE AGED; MULTIVARIATE ANALYSIS; PARASITOLOGY; PREDICTIVE VALUE; PROGNOSIS; RADIATION DOSE; SCHISTOSOMIASIS; STATISTICAL MODEL; TREATMENT OUTCOME;

ANIMALS; BCL-X PROTEIN; CARCINOMA, SQUAMOUS CELL; CYSTECTOMY; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; LOGISTIC MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROSPECTIVE STUDIES; RADIOTHERAPY DOSAGE; RADIOTHERAPY, ADJUVANT; SCHISTOSOMIASIS; TREATMENT OUTCOME; URINARY BLADDER NEOPLASMS;

EID: 78651232276     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-11-16     Document Type: Article

References (21)

1. Shokeir AA, . Squamous cell carcinoma of the bladder Pathology, diagnosis and treatment. BJU Int 2004, 93(2):216-20. 10.1111/j.1464-410X.2004.04588.x, 14690486, Squamous cell carcinoma of the bladder.
2. Ghoneim M, El-Mekresh M, El-Baz M, El-Attar I, Ashamallah A. Radical cystectomy for carcinoma of the bladder. Critical evaluation of the results in 1026 cases. J Urol 1997, 158:393-9. 10.1016/S0022-5347(01)64487-2, 9224310.
3. Zarzour AH, Selim M, Abd-Elsayed AA, Hameed DA, AbdelAziz MA. Muscle invasive bladder cancer in Upper Egypt: the shift in risk factors and tumor characteristics. BMC Cancer 2008, 8:250. 10.1186/1471-2407-8-250, 2533340, 18759990.
4. Khaled HM. Bladder cancer and bilharziasis today. Cancer J 1993, 6:65-71.
5. Murthy V, Zaghloul MS. Adjuvant radiotherapy in bladder cancer: Time to take a fresh look?. Urol Oncol 2007, 25:353-4.
6. Darzynkiewicz Z. Apoptosis in antitumor strategies: modulation of cell cycle or differentiation. J Cell Biochem 1995, 58:151-9. 10.1002/jcb.240580204, 7673323.
7. Cheng E, Levine B, Boise L, Thompson C, Hardwick J. BAX-independent inhibition of apoptosis by Bcl-XL. Nature 1996, 379:554-6. 10.1038/379554a0, 8596636.
8. Streffer JR, Rimner A, Rieger J, Naumann U, Rodemann HP, Weller M. Bcl-2 family proteins modulate radiosensitivity in human malignant glioma cells. J Neurooncol 2002, 56:43-9. 10.1023/A:1014448721327, 11949826.
9. Datta R, Manome Y, Taneja N, Boise LH, Weichselbaum R, Thompson CB, Slapak CA, Kufe D. Overexpression of Bcl-XL by cytotoxic drug exposure confers resistance to ionizing radiation-induced internucleosomal DNA fragmentation. Cell Growth Differ 1995, 6:363-70.
10. Lee JU, Hosotani R, Wada M, Doi R, Kosiba T, Fujimoto K, Miyamoto Y, Tsuji S, Nakajima S, Nishimura Y, Imamura M. Role of Bcl-2 family proteins (Bax, Bcl-2 and Bcl-X) on cellular susceptibility to radiation in pancreatic cancer cells. Eur J Cancer 1999, 35:1374-80. 10.1016/S0959-8049(99)00134-3, 10658530.
11. Hameed DA, Abdel Raheem AM, Mosad E, Hammouda HM, Kamel NA, Abdel Aziz MA. Bcl-XL and Bcl-2 Expression in Bilharzial Squamous Cell Carcinoma of the Urinary Bladder: Which Protein Is Prognostic?. UROLOGY 2008, 72:374-378. 10.1016/j.urology.2007.12.063, 18342927.
12. Bethesda M. Common Toxicity Criteria Manual. 1999, National Cancer Institute.
13. Zaghloul MS, Awwad HK, Akoush HH, Omar S, Soliman O, El-Attar I. Postoperative radiotherapy of carcinoma in bilharzial bladder: improved disease free survival through improving local control. Int J Radiat Oncol Biol Phys 1992, 23:511-7. 10.1016/0360-3016(92)90005-3, 1612951.
14. Stein JP, Lieskovsky G, Cote R, Groshen S, Feng AC, Boyd S, Skinner E, Bochner B, Thangathurai D, Mikhail M, Raghavan D, Skinner DG. Radical cystectomy in the treatment of invasive bladder cancer: Long-term results in 1054 patients. J Clin Oncol 2001, 19:666-75.
15. Konety BR, Joslyn SA, O'Donnel MA. Extent of pelvic lymphadenectomy and its impact on outcome in patients diagnosed with bladder cancer: Analysis of data from the surveillance, epidemiology, and end results (SEER) program database. J Urol 2003, 169:945-50.
16. Kaufman D, Shipley W, Feldman A. Bladder cancer. Lancet 2009, 374(9685):239-249. 10.1016/S0140-6736(09)60491-8, 19520422.
17. Reisinger S, Mohiuddin M, Mulholland S. Combined pre- and postoperative adjuvant radiation therapy for bladder cancer--a ten years experience. Int J Radiat Oncol Biol Phys 1992, 24:463-8. 10.1016/0360-3016(92)91060-Z, 1399731.
18. Zaghloul MS, Nouh A, Nazmy M, Ramzy S, Zaghloul AS, Sedira MA, Khalil E. Long-term results of primary adenocarcinoma of the urinary bladder: A report on 192 patients. Urol Oncol 2006, 24:13-20.
19. Sellers W, Fisher D. Apoptosis and cancer drug targeting. J Clin Invest 1999, 104:1655-61. 10.1172/JCI9053, 409892, 10606616.
20. Kojima H, Endo K, Moriyama H, Tanaka Y, Alnemri ES, Slapak CA, Teicher B, Kufe D, Datta R. Abrogation of mitochondrial cytochrome-C release and caspase-3 activation in acquired multidrug resistance. J Biol Chem 1998, 272:16647-50.
21. Ong F, Moonen LM, Gallee MP, ten Bosch C, Zerp SF, Hart AA, Bartelink H, Verheij M. Prognostic factors in transitional cell cancer of the bladder: an emerging role for Bcl-2 and p53. Radiother Oncol 2001, 61:169-75. 10.1016/S0167-8140(01)00421-2, 11690683.