Recycling and reutilization of cytotoxic molecules, a new type of energy conservation of NK cells?

Medical Hypotheses

Volumn 76, Issue 2, 2011, Pages 293-295

  Li, Pan ^a   Katirai, Foad ^a   Zheng, Fang ^a   Gong, Feili ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GRANZYME; PERFORIN;

ARTICLE; CELL KILLING; CELL THERAPY; CELL VACUOLE; CYTOTOXICITY; ENDOCYTOSIS; ENERGY CONSERVATION; HUMAN; IMMUNOLOGICAL SYNAPSE; LYSOSOME; NATURAL KILLER CELL;

ANTIGEN-PRESENTING CELLS; CYTOPLASM; ENDOCYTOSIS; ENDOSOMES; EXOCYTOSIS; GRANZYMES; HUMANS; IMMUNE SYSTEM; IMMUNOLOGICAL SYNAPSES; KILLER CELLS, NATURAL; LYSOSOMES; MODELS, BIOLOGICAL; MODELS, THEORETICAL; PERFORIN; T-LYMPHOCYTES;

EID: 78651112418     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2010.10.027     Document Type: Article

References (18)

1. Smyth M.J., Cretney E., Kelly J.M., et al. Activation of NK cell cytotoxicity. Mol Immunol 2005, 42:501-510.
2. Blott E.J., Griffiths G.M. Secretory lysosomes. Nat Rev Mol Cell Biol 2002, 3:122-131.
3. Clark R., Griffiths G.M. Lytic granules, secretory lysosomes and disease. Curr Opin Immunol 2003, 15:516-521.
4. Bossi G., Trambas C., Booth S., Clark R., Stinchcombe J., Griffiths G.M. The secretory synapse: the secrets of a serial killer. Immunol Rev 2002, 189:152-160.
5. Topham N.J., Hewitt E.W. Natural killer cell cytotoxicity: how do they pull the trigger?. Immunology 2009, 128:7-15.
6. Roda-Navarro P., Reyburn H.T. Intercellular protein transfer at the NK cell immune synapse: mechanisms and physiological significance. FASEB J 2007, 21:1636-1646.
7. Davis D.M., Dustin M.L. What is the importance of the immunological synapse?. Trends Immunol 2004, 25:323-327.
8. Schweizer F.E., Ryan T.A. The synaptic vesicle: cycle of exocytosis and endocytosis. Curr Opin Neurobiol 2006, 16:298-304.
9. Rizzoli S.O., Jahn R. Kiss-and-run, collapse and 'readily retrievable' vesicles. Traffic 2007, 8:1137-1144.
10. Shaw A.S., Allen P.M. Kissing cousins: immunological and neurological synapses. Nat Immunol 2001, 2:575-576.
11. Holroyd P., Lang T., Wenzel D., De Camilli P., Jahn R. Imaging direct, dynamin-dependent recapture of fusing secretory granules on plasma membrane lawns from PC12 cells. Proc Natl Acad Sci USA 2002, 99:16806-16811.
12. Taraska J.W., Perrais D., Ohara-Imaizumi M., Nagamatsu S., Almers W. Secretory granules are recaptured largely intact after stimulated exocytosis in cultured endocrine cells. Proc Natl Acad Sci USA 2003, 100:2070-2075.
13. Li P., Zheng G., Yang Y., Zhang C., Zheng F., Gong F. Granzyme B is recovered by natural killer cells via clathrin-dependent endocytosis. Cell Mol Life Sci 2010, 67:3197-3208.
14. Liu D., Xu L., Yang F., Li D., Gong F., Xu T. Rapid biogenesis and sensitization of secretory lysosomes in NK cells mediated by target-cell recognition. Proc Natl Acad Sci USA 2005, 102:123-127.
15. Bhat R., Watzl C. Serial killing of tumor cells by human natural killer cells - Enhancement by therapeutic antibodies. PLoS One 2007, 2:e326.
16. Cousin M.A., Robinson P.J. Mechanisms of synaptic vesicle recycling illuminated by fluorescent dyes. J Neurochem 1999, 73:2227-2239.
17. Waldmann T.A., Dubois S., Tagaya Y. Contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: implications for immunotherapy. Immunity 2001, 14:105-110.
18. Waldmann T.A. The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design. Nat Rev Immunol 2006, 6:595-601.