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Volumn 8, Issue 1, 2010, Pages 10-16

The current and emerging role of immunotherapy in prostate cancer

Author keywords

Cancer Vaccine; Treatment

Indexed keywords

ACID PHOSPHATASE PROSTATE ISOENZYME; CANCER VACCINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; IPILIMUMAB; KETOCONAZOLE; PLACEBO; PROSTVAC; PROVENGE; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

EID: 78651103349     PISSN: 15587673     EISSN: 19380682     Source Type: Journal    
DOI: 10.3816/CGC.2010.n.002     Document Type: Review
Times cited : (8)

References (74)
  • 1
    • 4744366279 scopus 로고    scopus 로고
    • Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer
    • Tannock IF, de Wit R, Berry WR, et al. Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. N Engl J Med 2004; 351:1502-12.
    • (2004) N Engl J Med , vol.351 , pp. 1502-1512
    • Tannock, I.F.1    De Wit, R.2    Berry, W.R.3
  • 2
    • 4744337716 scopus 로고    scopus 로고
    • Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer
    • Petrylak DP, Tangen CM, Hussain MH, et al. Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer. N Engl J Med 2004; 351:1513-20.
    • (2004) N Engl J Med , vol.351 , pp. 1513-1520
    • Petrylak, D.P.1    Tangen, C.M.2    Hussain, M.H.3
  • 3
    • 77952656376 scopus 로고    scopus 로고
    • Cabazitaxel or mitoxantrone with prednisone in patients with metastatic castration-resistant prostate cancer (mCRPC) previously treated with docetaxel: Final results of a multinational phase III trial (TROPIC)
    • March 5-7 San Francisco, California (Abstract 9)
    • Sartor A, Oudard S, Ozguroglu M, et al. Cabazitaxel or mitoxantrone with prednisone in patients with metastatic castration-resistant prostate cancer (mCRPC) previously treated with docetaxel: Final results of a multinational phase III trial (TROPIC). Presented at: ASCO Genitourinary Cancers Symposium; March 5-7, 2010; San Francisco, California (Abstract 9).
    • (2010) Presented at: ASCO Genitourinary Cancers Symposium
    • Sartor, A.1    Oudard, S.2    Ozguroglu, M.3
  • 4
    • 85206955715 scopus 로고    scopus 로고
    • FDA approves a cellular immunotherapy for men with advanced prostate cancer. April 29, 2010. Available at Accessed: June 7
    • FDA approves a cellular immunotherapy for men with advanced prostate cancer. April 29, 2010. Available at: Http://www.fda.gov/NewsEvents/Newsroom/ PressAnnouncements/ucm210174.htm. Accessed: June 7, 2010.
    • (2010)
  • 5
    • 65649090203 scopus 로고    scopus 로고
    • Development of a second-generation antiandrogen for treatment of advanced prostate cancer
    • Tran C, Ouk S, Clegg NJ, et al. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science 2009; 324:787-90.
    • (2009) Science , vol.324 , pp. 787-790
    • Tran, C.1    Ouk, S.2    Clegg, N.J.3
  • 7
    • 22144484150 scopus 로고    scopus 로고
    • Androgen deprivation therapy for prostate cancer
    • Sharifi N, Gulley JL, Dahut WL. Androgen deprivation therapy for prostate cancer. JAMA 2005; 294:238-44.
    • (2005) JAMA , vol.294 , pp. 238-244
    • Sharifi, N.1    Gulley, J.L.2    Dahut, W.L.3
  • 8
    • 77957262389 scopus 로고    scopus 로고
    • Vaccines as monotherapy and in combination therapy for prostate cancer
    • Rotow J, Gameiro SR, Madan RA, et al. Vaccines as monotherapy and in combination therapy for prostate cancer. Clin Transl Sci 2010; 3:116-22.
    • (2010) Clin Transl Sci , Issue.3 , pp. 116-122
    • Rotow, J.1    Gameiro, S.R.2    Madan, R.A.3
  • 9
    • 20944441967 scopus 로고    scopus 로고
    • Combining a recombinant cancer vaccine with standard definitive radiotherapy in patients with localized prostate cancer
    • Gulley JL, Arlen PM, Bastian A, et al. Combining a recombinant cancer vaccine with standard definitive radiotherapy in patients with localized prostate cancer. Clin Cancer Res 2005; 11:3353-62.
    • (2005) Clin Cancer Res , vol.11 , pp. 3353-3362
    • Gulley, J.L.1    Arlen, P.M.2    Bastian, A.3
  • 10
    • 85206956354 scopus 로고    scopus 로고
    • FDAPrescribing Information for Provenge. Available at Accessed: October 1
    • FDAPrescribing Information for Provenge. Available at: Http://www.fda.gov/downloads/BiologicsBloodVaccines/CellularGeneTherapyProducts/ ApprovedProducts/UCM210031.pdf. Accessed: October 1, 2010.
    • (2010)
  • 11
    • 0036083073 scopus 로고    scopus 로고
    • Technology evaluation: APC-8015
    • Rini BI. Technology evaluation: APC-8015, Dendreon. Curr Opin Mol Ther 2002; 4:76-9.
    • (2002) Dendreon Curr Opin Mol Ther , vol.4 , pp. 76-79
    • Rini, B.I.1
  • 12
    • 38049048619 scopus 로고    scopus 로고
    • Sipuleucel-T: A vaccine for metastatic, asymptomatic, androgen-independent prostate cancer
    • Patel PH, Kockler DR. Sipuleucel-T: A vaccine for metastatic, asymptomatic, androgen-independent prostate cancer. Ann Pharmacother 2008; 42:91-8.
    • (2008) Ann Pharmacother , vol.42 , pp. 91-98
    • Patel, P.H.1    Kockler, D.R.2
  • 13
    • 0034554863 scopus 로고    scopus 로고
    • Immunotherapy of hormone-refractory prostate cancer with antigen-loaded dendritic cells
    • Small EJ, Fratesi P, Reese DM, et al. Immunotherapy of hormone-refractory prostate cancer with antigen-loaded dendritic cells. J Clin Oncol 2000; 18:3894-903.
    • (2000) J Clin Oncol , vol.18 , pp. 3894-3903
    • Small, E.J.1    Fratesi, P.2    Reese, D.M.3
  • 14
    • 3242747658 scopus 로고    scopus 로고
    • Immunotherapy (APC8015, Provenge) targeting prostatic acid phosphatase can induce durable remission of metastatic androgen-independent prostate cancer: A phase 2 trial
    • Burch PA, Croghan GA, Gastineau DA, et al. Immunotherapy (APC8015, Provenge) targeting prostatic acid phosphatase can induce durable remission of metastatic androgen-independent prostate cancer: A phase 2 trial. Prostate 2004; 60:197-204.
    • (2004) Prostate , vol.60 , pp. 197-204
    • Burch, P.A.1    Croghan, G.A.2    Gastineau, D.A.3
  • 15
    • 22544458183 scopus 로고    scopus 로고
    • Antigen-presenting cells 8015 (Provenge) in patients with androgen-dependent, biochemically relapsed prostate cancer
    • Beinart G, Rini BI, Weinberg V, et al. Antigen-presenting cells 8015 (Provenge) in patients with androgen-dependent, biochemically relapsed prostate cancer. Clin Prostate Cancer 2005; 4:55-60.
    • (2005) Clin Prostate Cancer , vol.4 , pp. 55-60
    • Beinart, G.1    Rini, B.I.2    Weinberg, V.3
  • 16
    • 33746012881 scopus 로고    scopus 로고
    • Placebo-controlled phase III trial of immunologic therapy with sipuleucel-T (APC8015) in patients with metastatic, asymptomatic hormone refractory prostate cancer
    • Small EJ, Schellhammer PF, Higano CS, et al. Placebo-controlled phase III trial of immunologic therapy with sipuleucel-T (APC8015) in patients with metastatic, asymptomatic hormone refractory prostate cancer. J Clin Oncol 2006; 24:3089-94.
    • (2006) J Clin Oncol , vol.24 , pp. 3089-3094
    • Small, E.J.1    Schellhammer, P.F.2    Higano, C.S.3
  • 17
    • 68549135290 scopus 로고    scopus 로고
    • Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer
    • Higano CS, Schellhammer PF, Small EJ, et al. Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer. Cancer 2009; 115:3670-9.
    • (2009) Cancer , vol.115 , pp. 3670-3679
    • Higano, C.S.1    Schellhammer, P.F.2    Small, E.J.3
  • 18
    • 77955066199 scopus 로고    scopus 로고
    • Sipuleucel-T immunotherapy for castration-resistant prostate cancer
    • Kantoff PW, Higano CS, Shore ND, et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med 2010; 363:411-22.
    • (2010) N Engl J Med , Issue.363 , pp. 411-422
    • Kantoff, P.W.1    Higano, C.S.2    Shore, N.D.3
  • 19
    • 67650463335 scopus 로고    scopus 로고
    • Prostvac-VF: A vector-based vaccine targeting PSA in prostate cancer
    • Madan RA, Arlen PM, Mohebtash M, et al. Prostvac-VF: A vector-based vaccine targeting PSA in prostate cancer. Expert Opin Investig Drugs 2009; 18:1001-11.
    • (2009) Expert Opin Investig Drugs , vol.18 , pp. 1001-1011
    • Madan, R.A.1    Arlen, P.M.2    Mohebtash, M.3
  • 20
    • 1842684059 scopus 로고    scopus 로고
    • Poxvirus vaccines for cancer and HIV therapy
    • Essajee S, Kaufman HL. Poxvirus vaccines for cancer and HIV therapy. Expert Opin Biol Ther 2004; 4:575-88.
    • (2004) Expert Opin Biol Ther , vol.4 , pp. 575-588
    • Essajee, S.1    Kaufman, H.L.2
  • 21
    • 0036787490 scopus 로고    scopus 로고
    • Phase I study of a vaccine using recombinant vaccinia virus expressing PSA (rV-PSA) in patients with metastatic androgen-independent prostate cancer
    • Gulley J, Chen AP, Dahut W, et al. Phase I study of a vaccine using recombinant vaccinia virus expressing PSA (rV-PSA) in patients with metastatic androgen-independent prostate cancer. Prostate 2002; 53:109-17.
    • (2002) Prostate , vol.53 , pp. 109-117
    • Gulley, J.1    Chen, A.P.2    Dahut, W.3
  • 22
    • 2942644684 scopus 로고    scopus 로고
    • Phase II randomized study of vaccine treatment of advanced prostate cancer (E7897): A trial of the Eastern Cooperative Oncology Group
    • Kaufman HL, Wang W, Manola J, et al. Phase II randomized study of vaccine treatment of advanced prostate cancer (E7897): A trial of the Eastern Cooperative Oncology Group. J Clin Oncol 2004; 22:2122-32.
    • (2004) J Clin Oncol , vol.22 , pp. 2122-2132
    • Kaufman, H.L.1    Wang, W.2    Manola, J.3
  • 23
    • 34548452131 scopus 로고    scopus 로고
    • Clinical safety of a viral vector based prostate cancer vaccine strategy
    • Arlen PM, Skarupa L, Pazdur M, et al. Clinical safety of a viral vector based prostate cancer vaccine strategy. J Urol 2007; 178:1515-20.
    • (2007) J Urol , vol.178 , pp. 1515-1520
    • Arlen, P.M.1    Skarupa, L.2    Pazdur, M.3
  • 24
    • 67650465159 scopus 로고    scopus 로고
    • A phase II study of PROSTVAC-V (vaccinia)/TRICOM and PROSTVAC-F (fowlpox)/TRICOM with GM-CSF in patients with PSA progression after local therapy for prostate cancer: Results of ECOG 9802
    • February 26-28, Orlando, Florida (Abstract 108)
    • DiPaola R, Chen Y, Bubley G, et al. A phase II study of PROSTVAC-V (vaccinia)/TRICOM and PROSTVAC-F (fowlpox)/TRICOM with GM-CSF in patients with PSA progression after local therapy for prostate cancer: Results of ECOG 9802. Presented at: ASCO Genitourinary Cancers Symposium; February 26-28, 2009; Orlando, Florida (Abstract 108).
    • (2009) Presented at: ASCO Genitourinary Cancers Symposium
    • DiPaola, R.1    Chen, Y.2    Bubley, G.3
  • 25
    • 0033571120 scopus 로고    scopus 로고
    • A triad of costimulatory molecules synergize to amplify T-cell activation
    • Hodge JW, Sabzevari H, Yafal AG, et al. A triad of costimulatory molecules synergize to amplify T-cell activation. Cancer Res 1999; 59:5800-7.
    • (1999) Cancer Res , vol.59 , pp. 5800-5807
    • Hodge, J.W.1    Sabzevari, H.2    Yafal, A.G.3
  • 26
    • 0037108688 scopus 로고    scopus 로고
    • Vector-based vaccine/cytokine combination therapy to enhance induction of immune responses to a self-antigen and antitumor activity
    • Aarts WM, Schlom J, Hodge JW. Vector-based vaccine/cytokine combination therapy to enhance induction of immune responses to a self-antigen and antitumor activity. Cancer Res 2002; 62:5770-7.
    • (2002) Cancer Res , vol.62 , pp. 5770-5777
    • Aarts, W.M.1    Schlom, J.2    Hodge, J.W.3
  • 27
    • 0035360260 scopus 로고    scopus 로고
    • Synergy of vaccine strategies to amplify antigen-specific immune responses and antitumor effects
    • Grosenbach DW, Barrientos JC, Schlom J, et al. Synergy of vaccine strategies to amplify antigen-specific immune responses and antitumor effects. Cancer Res 2001; 61:4497-505.
    • (2001) Cancer Res , vol.61 , pp. 4497-4505
    • Grosenbach, D.W.1    Barrientos, J.C.2    Schlom, J.3
  • 28
    • 77949895922 scopus 로고    scopus 로고
    • Overall survival analysis of a phase II randomized controlled trial of a Poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer
    • Kantoff PW, Schuetz TJ, Blumenstein BA, et al. Overall survival analysis of a phase II randomized controlled trial of a Poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer. J Clin Oncol 2010; 28:1099-105.
    • (2010) J Clin Oncol , Issue.28 , pp. 1099-1105
    • Kantoff, P.W.1    Schuetz, T.J.2    Blumenstein, B.A.3
  • 29
    • 77950473925 scopus 로고    scopus 로고
    • Immunologic and prognostic factors associated with overall survival employing a poxviral-based PSA vaccine in metastatic castrate-resistant prostate cancer
    • Gulley JL, Arlen PM, Madan RA, et al. Immunologic and prognostic factors associated with overall survival employing a poxviral-based PSA vaccine in metastatic castrate-resistant prostate cancer. Cancer Immunol Immunother 2010; 59:663-74.
    • (2010) Cancer Immunol Immunother , Issue.59 , pp. 663-674
    • Gulley, J.L.1    Arlen, P.M.2    Madan, R.A.3
  • 30
    • 85206958291 scopus 로고    scopus 로고
    • PROSTVAC: Therapeutic vaccine candidate for the treatment of advanced prostate cancer. Available at Accessed: July 20
    • PROSTVAC: Therapeutic vaccine candidate for the treatment of advanced prostate cancer. Available at: Http://www.bavarian-nordic.com/pipeline/prostvac. aspx. Accessed: July 20, 2010.
    • (2010)
  • 31
    • 0028791059 scopus 로고
    • Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
    • Waterhouse P, Penninger JM, Timms E, et al. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 1995; 270:985-8.
    • (1995) Science , vol.270 , pp. 985-988
    • Waterhouse, P.1    Penninger, J.M.2    Timms, E.3
  • 32
    • 0036301503 scopus 로고    scopus 로고
    • CTLA-4: New insights into its biological function and use in tumor immunotherapy
    • Egen JG, Kuhns MS, Allison JP. CTLA-4: New insights into its biological function and use in tumor immunotherapy. Nat Immunol 2002; 3:611-8.
    • (2002) Nat Immunol , vol.3 , pp. 611-618
    • Egen, J.G.1    Kuhns, M.S.2    Allison, J.P.3
  • 33
    • 0031614848 scopus 로고    scopus 로고
    • A role for CTLA-4-mediated inhibitory signals in peripheral T cell tolerance?
    • discussion 8-102, 86-90
    • Allison JP, Chambers C, Hurwitz A, et al. A role for CTLA-4-mediated inhibitory signals in peripheral T cell tolerance? Novartis Found Symp 1998; 215:92-8; discussion 8-102, 86-90.
    • (1998) Novartis Found Symp , vol.215 , pp. 92-98
    • Allison, J.P.1    Chambers, C.2    Hurwitz, A.3
  • 34
    • 18644376211 scopus 로고    scopus 로고
    • Multiple costimulatory modalities enhance CTL avidity
    • Hodge JW, Chakraborty M, Kudo-Saito C, et al. Multiple costimulatory modalities enhance CTL avidity. J Immunol 2005; 174:5994-6004.
    • (2005) J Immunol , vol.174 , pp. 5994-6004
    • Hodge, J.W.1    Chakraborty, M.2    Kudo-Saito, C.3
  • 35
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, O'Day SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 2010; 363:711-23.
    • (2010) N Engl J Med , Issue.363 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 36
    • 34250223096 scopus 로고    scopus 로고
    • A pilot trial of CTLA-4 blockade with human anti-CTLA-4 in patients with hormone-refractory prostate cancer
    • Small EJ, Tchekmedyian NS, Rini BI, et al. A pilot trial of CTLA-4 blockade with human anti-CTLA-4 in patients with hormone-refractory prostate cancer. Clin Cancer Res 2007; 13:1810-5.
    • (2007) Clin Cancer Res , vol.13 , pp. 1810-1815
    • Small, E.J.1    Tchekmedyian, N.S.2    Rini, B.I.3
  • 37
    • 57349099926 scopus 로고    scopus 로고
    • Expanded phase I combination trial of GVAX immunotherapy for prostate cancer and ipilimumab in patients with metastatic hormone-refractory prostate cancer (mHPRC)
    • abstract 5146
    • Gerritsen W, van den Eertwegh A, de Gruijl T, et al. Expanded phase I combination trial of GVAX immunotherapy for prostate cancer and ipilimumab in patients with metastatic hormone-refractory prostate cancer (mHPRC). J Clin Oncol 2008; 26(15 suppl):285s (abstract 5146).
    • (2008) J Clin Oncol , vol.26 , Issue.15 SUPPL.
    • Gerritsen, W.1    Van Den Eertwegh, A.2    De Gruijl, T.3
  • 38
    • 78651295599 scopus 로고    scopus 로고
    • Overall survival analysis of a phase l trial of a vector-based vaccine (PSA-TRICOM) and ipilimumab in the treatment of metastatic castration-resistant prostate cancer
    • abstract 2550
    • Madan R, Mohebtash M, Arlen P, et al. Overall survival analysis of a phase l trial of a vector-based vaccine (PSA-TRICOM) and ipilimumab in the treatment of metastatic castration-resistant prostate cancer. J Clin Oncol 2010; 28(15 suppl):216s (abstract 2550).
    • (2010) J Clin Oncol , vol.28 , Issue.15 SUPPL.
    • Madan, R.1    Mohebtash, M.2    Arlen, P.3
  • 41
    • 28744439520 scopus 로고    scopus 로고
    • Inter-operator variation in ELISPOT analysis of measles virus-specific IFN-gamma-secreting T cells
    • Ryan JE, Ovsyannikova IG, Dhiman N, et al. Inter-operator variation in ELISPOT analysis of measles virus-specific IFN-gamma-secreting T cells. Scand J Clin Lab Invest 2005; 65:681-9.
    • (2005) Scand J Clin Lab Invest , vol.65 , pp. 681-689
    • Ryan, J.E.1    Ovsyannikova, I.G.2    Dhiman, N.3
  • 42
    • 19944431341 scopus 로고    scopus 로고
    • Results of an ELISPOT proficiency panel conducted in 11 laboratories participating in international human immunodeficiency virus type 1 vaccine trials
    • Cox JH, Ferrari G, Kalams SA, et al. Results of an ELISPOT proficiency panel conducted in 11 laboratories participating in international human immunodeficiency virus type 1 vaccine trials. AIDS Res Hum Retroviruses 2005; 21:68-81.
    • (2005) AIDS Res Hum Retroviruses , vol.21 , pp. 68-81
    • Cox, J.H.1    Ferrari, G.2    Kalams, S.A.3
  • 43
    • 55049137067 scopus 로고    scopus 로고
    • Tumor growth rates derived from data for patients in a clinical trial correlate strongly with patient survival: A novel strategy for evaluation of clinical trial data
    • Stein WD, Figg WD, Dahut W, et al. Tumor growth rates derived from data for patients in a clinical trial correlate strongly with patient survival: A novel strategy for evaluation of clinical trial data. Oncologist 2008; 13:1046-54.
    • (2008) Oncologist , vol.13 , pp. 1046-1054
    • Stein, W.D.1    Figg, W.D.2    Dahut, W.3
  • 44
    • 79951848170 scopus 로고    scopus 로고
    • Kinetic analysis of breast tumor decay and growth following ixabepilone plus capecitabine (IXA + CAP) versus capecitabine alone (CAP) to discern whether the superiority of the combination is a result of slower growth, enhanced tumor cell kill, or both
    • abstract 1096
    • Fojo A, Stein W, Wilkerson J, et al. Kinetic analysis of breast tumor decay and growth following ixabepilone plus capecitabine (IXA + CAP) versus capecitabine alone (CAP) to discern whether the superiority of the combination is a result of slower growth, enhanced tumor cell kill, or both. J Clin Oncol 2010; 28(15 suppl):137s (abstract 1096).
    • (2010) J Clin Oncol , vol.28 , Issue.15 SUPPL.
    • Fojo, A.1    Stein, W.2    Wilkerson, J.3
  • 45
    • 78651059964 scopus 로고    scopus 로고
    • Validation of a kinetic analysis of renal cancer regression and growth following treatment with sunitinib and interferon-alfa (IFN-alpha): Analysis of the pivotal randomized trial
    • abstract 4597
    • Wilkerson J, Stein W, Kim S, et al. Validation of a kinetic analysis of renal cancer regression and growth following treatment with sunitinib and interferon-alfa (IFN-alpha): Analysis of the pivotal randomized trial. J Clin Oncol 2010; 28(15 suppl):366s (abstract 4597).
    • (2010) J Clin Oncol , vol.28 , Issue.15 SUPPL.
    • Wilkerson, J.1    Stein, W.2    Kim, S.3
  • 46
    • 77957804545 scopus 로고    scopus 로고
    • A retrospective analysis of intramural NCI prostate cancer trials: Progress made and insights gleaned
    • abstract 4657
    • Gulley J, Stein W, Schlom J, et al. A retrospective analysis of intramural NCI prostate cancer trials: Progress made and insights gleaned. J Clin Oncol 2010; 28(15 suppl):380s (abstract 4657).
    • (2010) J Clin Oncol , vol.28 , Issue.15 SUPPL.
    • Gulley, J.1    Stein, W.2    Schlom, J.3
  • 47
    • 78651064712 scopus 로고    scopus 로고
    • Tumor regression and growth rates determined in five intramural NCI prostate cancer trials. The growth rate as an indicator of therapeutic efficacy
    • November 24 [Epub ahead of print]
    • Stein WD, Gulley J, Schlom J, et al. Tumor regression and growth rates determined in five intramural NCI prostate cancer trials. The growth rate as an indicator of therapeutic efficacy. Clin Cancer Res 2010; November 24 [Epub ahead of print].
    • (2010) Clin Cancer Res
    • Stein, W.D.1    Gulley, J.2    Schlom, J.3
  • 48
    • 0038514138 scopus 로고    scopus 로고
    • Prognostic model for predicting survival in men with hormone-refractory metastatic prostate cancer
    • Halabi S, Small EJ, Kantoff PW, et al. Prognostic model for predicting survival in men with hormone-refractory metastatic prostate cancer. J Clin Oncol 2003; 21:1232-7.
    • (2003) J Clin Oncol , vol.21 , pp. 1232-1237
    • Halabi, S.1    Small, E.J.2    Kantoff, P.W.3
  • 49
    • 0035421654 scopus 로고    scopus 로고
    • Cutting edge: Control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells
    • Piccirillo CA, Shevach EM. Cutting edge: Control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells. J Immunol 2001; 167:1137-40.
    • (2001) J Immunol , vol.167 , pp. 1137-1140
    • Piccirillo, C.A.1    Shevach, E.M.2
  • 50
    • 0036569127 scopus 로고    scopus 로고
    • Cutting edge: Regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation
    • Woo EY, Yeh H, Chu CS, et al. Cutting edge: Regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation. J Immunol 2002; 168:4272-6.
    • (2002) J Immunol , vol.168 , pp. 4272-4276
    • Woo, E.Y.1    Yeh, H.2    Chu, C.S.3
  • 51
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S, Sakaguchi N, Asano M, et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995; 155:1151-64.
    • (1995) J Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3
  • 52
    • 0036909644 scopus 로고    scopus 로고
    • Immunoregulatory T cells in cancer immunotherapy
    • Morse MA, Clay TM, Mosca P, et al. Immunoregulatory T cells in cancer immunotherapy. Expert Opin Biol Ther 2002; 2:827-34.
    • (2002) Expert Opin Biol Ther , vol.2 , pp. 827-834
    • Morse, M.A.1    Clay, T.M.2    Mosca, P.3
  • 53
    • 0034716925 scopus 로고    scopus 로고
    • Regulatory T cells: Key controllers of immunologic self-tolerance
    • Sakaguchi S. Regulatory T cells: Key controllers of immunologic self-tolerance. Cell 2000; 101:455-8.
    • (2000) Cell , vol.101 , pp. 455-458
    • Sakaguchi, S.1
  • 54
    • 79959542079 scopus 로고    scopus 로고
    • Changes in regulatory T cell function and overall survival in metastatic castration resistant prostate cancer (mCRPC) patients treated with a vector-based vaccine [poster presentation]
    • April 18-22, Denver, Colorado (Abstract 726)
    • Madan R, Vergati M, Cereda P, et al. Changes in regulatory T cell function and overall survival in metastatic castration resistant prostate cancer (mCRPC) patients treated with a vector-based vaccine [poster presentation]. Presented at: AACR Annual Meeting; April 18-22, 2009; Denver, Colorado (Abstract 726).
    • (2009) Presented at: AACR Annual Meeting
    • Madan, R.1    Vergati, M.2    Cereda, P.3
  • 55
    • 45149113853 scopus 로고    scopus 로고
    • Pain predicts overall survival in men with metastatic castration-refractory prostate cancer
    • Halabi S, Vogelzang NJ, Kornblith AB, et al. Pain predicts overall survival in men with metastatic castration-refractory prostate cancer. J Clin Oncol 2008; 26:2544-9.
    • (2008) J Clin Oncol , vol.26 , pp. 2544-2549
    • Halabi, S.1    Vogelzang, N.J.2    Kornblith, A.B.3
  • 56
    • 41949104346 scopus 로고    scopus 로고
    • Design and end points of clinical trials for patients with progressive prostate cancer and castrate levels of testosterone: Recommendations of the Prostate Cancer Clinical Trials Working Group
    • Scher HI, Halabi S, Tannock I, et al. Design and end points of clinical trials for patients with progressive prostate cancer and castrate levels of testosterone: Recommendations of the Prostate Cancer Clinical Trials Working Group. J Clin Oncol 2008; 26:1148-59.
    • (2008) J Clin Oncol , vol.26 , pp. 1148-1159
    • Scher, H.I.1    Halabi, S.2    Tannock, I.3
  • 57
    • 24744441000 scopus 로고    scopus 로고
    • Vaccines with enhanced co-stimulation maintain high avidity memory CTL
    • Yang S, Hodge JW, Grosenbach DW, et al. Vaccines with enhanced co-stimulation maintain high avidity memory CTL. J Immunol 2005; 175:3715-23.
    • (2005) J Immunol , vol.175 , pp. 3715-3723
    • Yang, S.1    Hodge, J.W.2    Grosenbach, D.W.3
  • 58
    • 0035807916 scopus 로고    scopus 로고
    • T cell infiltration of the prostate induced by androgen withdrawal in patients with prostate cancer
    • Mercader M, Bodner BK, Moser MT, et al. T cell infiltration of the prostate induced by androgen withdrawal in patients with prostate cancer. Proc Natl Acad Sci U S A 2001; 98:14565-70.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 14565-14570
    • Mercader, M.1    Bodner, B.K.2    Moser, M.T.3
  • 59
    • 34547700498 scopus 로고    scopus 로고
    • Impact of androgen-deprivation therapy on the immune system: Implications for combination therapy of prostate cancer
    • Aragon-Ching JB, Williams KM, Gulley JL. Impact of androgen-deprivation therapy on the immune system: Implications for combination therapy of prostate cancer. Front Biosci 2007; 12:4957-71.
    • (2007) Front Biosci , vol.12 , pp. 4957-4971
    • Aragon-Ching, J.B.1    Williams, K.M.2    Gulley, J.L.3
  • 60
    • 20244380618 scopus 로고    scopus 로고
    • Androgen ablation mitigates tolerance to a prostate/prostate cancer-restricted antigen
    • Drake CG, Doody AD, Mihalyo MA, et al. Androgen ablation mitigates tolerance to a prostate/prostate cancer-restricted antigen. Cancer Cell 2005; 7:239-49.
    • (2005) Cancer Cell , vol.7 , pp. 239-249
    • Drake, C.G.1    Doody, A.D.2    Mihalyo, M.A.3
  • 62
    • 50349091770 scopus 로고    scopus 로고
    • Combination of docetaxel and recombinant vaccine enhances T-cell responses and antitumor activity: Effects of docetaxel on immune enhancement
    • Garnett CT, Schlom J, Hodge JW. Combination of docetaxel and recombinant vaccine enhances T-cell responses and antitumor activity: Effects of docetaxel on immune enhancement. Clin Cancer Res 2008; 14:3536-44.
    • (2008) Clin Cancer Res , vol.14 , pp. 3536-3544
    • Garnett, C.T.1    Schlom, J.2    Hodge, J.W.3
  • 63
    • 20444496893 scopus 로고    scopus 로고
    • Unexpected association between induction of immunity to the universal tumor antigen CYP1B1 and response to next therapy
    • Gribben JG, Ryan DP, Boyajian R, et al. Unexpected association between induction of immunity to the universal tumor antigen CYP1B1 and response to next therapy. Clin Cancer Res 2005; 11:4430-6.
    • (2005) Clin Cancer Res , vol.11 , pp. 4430-4436
    • Gribben, J.G.1    Ryan, D.P.2    Boyajian, R.3
  • 64
    • 32944468708 scopus 로고    scopus 로고
    • Combination of p53 cancer vaccine with chemotherapy in patients with extensive stage small cell lung cancer
    • Antonia SJ, Mirza N, Fricke I, et al. Combination of p53 cancer vaccine with chemotherapy in patients with extensive stage small cell lung cancer. Clin Cancer Res 2006; 12:878-87.
    • (2006) Clin Cancer Res , vol.12 , pp. 878-887
    • Antonia, S.J.1    Mirza, N.2    Fricke, I.3
  • 65
    • 77958091193 scopus 로고    scopus 로고
    • Defining the optimal role of immunotherapy and chemotherapy: Advanced prostate cancer patients who receive sipuleucel-T (Provenge) followed by docetaxel derive greatest survival benefit [abstract]
    • November 8-11, New York, NY
    • Petrylak D. Defining the optimal role of immunotherapy and chemotherapy: Advanced prostate cancer patients who receive sipuleucel-T (Provenge) followed by docetaxel derive greatest survival benefit [abstract]. Presented at: Chemotherapy Foundation Symposium 14th Annual Meeting; November 8-11, 2006; New York, NY.
    • (2006) Presented at: Chemotherapy Foundation Symposium 14th Annual Meeting
    • Petrylak, D.1
  • 66
    • 51649128403 scopus 로고    scopus 로고
    • Analysis of overall survival in patients with nonmetastatic castration-resistant prostate cancer treated with vaccine, nilutamide, and combination therapy
    • Madan RA, Gulley JL, Schlom J, et al. Analysis of overall survival in patients with nonmetastatic castration-resistant prostate cancer treated with vaccine, nilutamide, and combination therapy. Clin Cancer Res 2008; 14:4526-31.
    • (2008) Clin Cancer Res , vol.14 , pp. 4526-4531
    • Madan, R.A.1    Gulley, J.L.2    Schlom, J.3
  • 67
    • 85206956152 scopus 로고    scopus 로고
    • Randomized phase II trial of docetaxel with or without PSA-TRICOM vaccine in patients with castrate-resistant metastatic prostate cancer. Available at Accessed: August 16
    • Randomized phase II trial of docetaxel with or without PSA-TRICOM vaccine in patients with castrate-resistant metastatic prostate cancer. Available at: Http://ecog.dfci.harvard.edu/active-reports/Genitourinary.html. Accessed: August 16, 2010.
    • (2010)
  • 68
    • 85206957325 scopus 로고    scopus 로고
    • Vaccine therapy with PROSTVAC/TRICOM and flutamide versus flutamide alone to treat prostate cancer. Available at Accessed: July 21
    • Vaccine therapy with PROSTVAC/TRICOM and flutamide versus flutamide alone to treat prostate cancer. Available at: Http://clinicaltrials.gov/ct2/show/ NCT00450463?term=Prostvac&rank=2. Accessed: July 21, 2010.
    • (2010)
  • 69
    • 0033637684 scopus 로고    scopus 로고
    • Irradiation induced expression of CD31, ICAM-1 and VCAM-1 in human microvascular endothelial cells
    • Quarmby S, Hunter RD, Kumar S. Irradiation induced expression of CD31, ICAM-1 and VCAM-1 in human microvascular endothelial cells. Anticancer Res 2000; 20:3375-81.
    • (2000) Anticancer Res , vol.20 , pp. 3375-3381
    • Quarmby, S.1    Hunter, R.D.2    Kumar, S.3
  • 70
    • 0035988623 scopus 로고    scopus 로고
    • Immune modulation by ionizing radiation and its implications for cancer immunotherapy
    • Friedman EJ. Immune modulation by ionizing radiation and its implications for cancer immunotherapy. Curr Pharm Des 2002; 8:1765-80.
    • (2002) Curr Pharm Des , vol.8 , pp. 1765-1780
    • Friedman, E.J.1
  • 71
    • 0037942745 scopus 로고    scopus 로고
    • Irradiation of tumor cells up-regulates Fas and enhances CTL lytic activity and CTL adoptive immunotherapy
    • Chakraborty M, Abrams SI, Camphausen K, et al. Irradiation of tumor cells up-regulates Fas and enhances CTL lytic activity and CTL adoptive immunotherapy. J Immunol 2003; 170:6338-47.
    • (2003) J Immunol , vol.170 , pp. 6338-6347
    • Chakraborty, M.1    Abrams, S.I.2    Camphausen, K.3
  • 72
    • 3042569675 scopus 로고    scopus 로고
    • External beam radiation of tumors alters phenotype of tumor cells to render them susceptible to vaccine-mediated T-cell killing
    • Chakraborty M, Abrams SI, Coleman CN, et al. External beam radiation of tumors alters phenotype of tumor cells to render them susceptible to vaccine-mediated T-cell killing. Cancer Res 2004; 64:4328-37.
    • (2004) Cancer Res , vol.64 , pp. 4328-4337
    • Chakraborty, M.1    Abrams, S.I.2    Coleman, C.N.3
  • 73
    • 77954600224 scopus 로고    scopus 로고
    • Samarium-153 treatment of bone pain in patients with metastatic prostate cancer
    • Petersen LJ, Lund L, Jonler M, et al. Samarium-153 treatment of bone pain in patients with metastatic prostate cancer. Dan Med Bull 2010; 57:A4154.
    • (2010) Dan Med Bull , Issue.57
    • Petersen, L.J.1    Lund, L.2    Jonler, M.3
  • 74
    • 85206956925 scopus 로고    scopus 로고
    • 153Sm-EDTMP with or without a PSA/TRICOM vaccine to treat men with androgen-insensitive prostate cancer. Available at Accessed: August 5
    • 153Sm-EDTMP with or without a PSA/TRICOM vaccine to treat men with androgen-insensitive prostate cancer. Available at: Http://clinicaltrials.gov/ ct2/show/NCT00450619?term=samarium-153&rank=13. Accessed: August 5, 2010.
    • (2010)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.