Insidious iron burden in pediatric patients with acute lymphoblastic leukemia

Pediatric Blood and Cancer

Volumn 56, Issue 3, 2011, Pages 368-371

  Eng, Jennifer ^a   Fish, Jonathan D ^a  

^a Northwell Health   (United States)

Author keywords

Acute lymphoblastic leukemia; Blood transfusions; Iron overload

Indexed keywords

HEMOGLOBIN; IRON;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; BLOOD TRANSFUSION; BLOOD VOLUME; ERYTHROCYTE CONCENTRATE; ERYTHROCYTE TRANSFUSION; FEMALE; HIGH RISK PATIENT; HUMAN; IRON OVERLOAD; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK ASSESSMENT; RISK FACTOR;

ADOLESCENT; ADULT; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; ERYTHROCYTE INDICES; ERYTHROCYTE TRANSFUSION; FEMALE; FERRITINS; HEMOGLOBINS; HUMANS; INFANT; IRON OVERLOAD; MALE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROGNOSIS; RETROSPECTIVE STUDIES; RISK FACTORS; YOUNG ADULT;

EID: 78651093832     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.22851     Document Type: Article

References (24)

1. Nathan PC, Wasilewski-Masker K, Janzen LA. Long-term outcomes in survivors of childhood acute lymphoblastic leukemia. Hematol Oncol Clin North Am 2009; 23: 1065-1082, vi-vii.
2. Vermylen C. What is new in iron overload? Eur J Pediatr 2008; 167: 377-381.
3. Aydinok Y, Darcan S, Polat A, et al. Endocrine complications in patients with beta-thalassemia major. J Trop Pediatr 2002; 48: 50-54.
4. Borgna-Pignatti C, Cappellini MD, De Stefano P, et al. Survival and complications in thalassemia. Ann NY Acad Sci 2005; 1054: 40-47.
5. Pennell DJ. T2* magnetic resonance and myocardial iron in thalassemia. Ann NY Acad Sci 2005; 1054: 373-378.
6. Olivieri NF, Brittenham GM. Iron-chelating therapy and the treatment of thalassemia. Blood 1997; 89: 739-761.
7. Wolfe L, Olivieri N, Sallan D, et al. Prevention of cardiac disease by subcutaneous deferoxamine in patients with thalassemia major. N Engl J Med 1985; 312: 1600-1603.
8. Michon J. Incidence of anemia in pediatric cancer patients in Europe: Results of a large, international survey. Med Pediatr Oncol 2002; 39: 448-450.
9. Buchanan GR. Blood transfusions in children with cancer and hematologic disorders: Why, when, and how? Pediatr Blood Cancer 2005; 44: 114-116.
10. Webb IJ, Anderson KC. Transfusion support in acute leukemias. Semin Oncol 1997; 24: 141-146.
11. Majhail NS, Lazarus HM, Burns LJ. Iron overload in hematopoietic cell transplantation. Bone Marrow Transplant 2008; 41: 997-1003.
12. Halonen P, Mattila J, Suominen P, et al. Iron overload in children who are treated for acute lymphoblastic leukemia estimated by liver siderosis and serum iron parameters. Pediatrics 2003; 111: 91-96.
13. Paananen P, Arola MO, Pelliniemi TT, et al. Evaluation of the effects of different transfusion trigger levels during the treatment of childhood acute lymphoblastic leukemia. J Pediatr Hematol Oncol 2009; 31: 745-749.
14. Lutz K, von Komorowski G, Durken M, et al. Myocardial iron overload in transfusion-dependent pediatric patients with acute leukemia. Pediatr Blood Cancer 2008; 51: 691-693.
15. Barton JC, Bertoli LF. Transfusion iron overload in adults with acute leukemia: Manifestations and therapy. Am J Med Sci 2000; 319: 73-78.
16. Franchini M, Gandini G, Veneri D, et al. Efficacy and safety of phlebotomy to reduce transfusional iron overload in adult, long-term survivors of acute leukemia. Transfusion 2004; 44: 833-837.
17. Mody R, Li S, Dover DC, et al. Twenty-five-year follow-up among survivors of childhood acute lymphoblastic leukemia: A report from the Childhood Cancer Survivor Study. Blood 2008; 111: 5515-5523.
18. Shander A, Sazama K. Clinical consequences of iron overload from chronic red blood cell transfusions, its diagnosis, and its management by chelation therapy. Transfusion 2010; 50: 1144-1155.
19. Roggero S, Quarello P, Vinciguerra T, et al. Severe iron overload in Blackfan-Diamond anemia: A case-control study. Am J Hematol 2009; 84: 729-732.
20. Armstrong GT, Liu Q, Yasui Y, et al. Late mortality among 5-year survivors of childhood cancer: A summary from the Childhood Cancer Survivor Study. J Clin Oncol 2009; 27: 2328-2338.
21. Oeffinger KC, Mertens AC, Sklar CA, et al. Chronic health conditions in adult survivors of childhood cancer. N Engl J Med 2006; 355: 1572-1582.
22. Pullarkat V, Blanchard S, Tegtmeier B, et al. Iron overload adversely affects outcome of allogeneic hematopoietic cell transplantation. Bone Marrow Transplant 2008; 42: 799-805.
23. Anderson LJ, Westwood MA, Holden S, et al. Myocardial iron clearance during reversal of siderotic cardiomyopathy with intravenous desferrioxamine: A prospective study using T2* cardiovascular magnetic resonance. Br J Haematol 2004; 127: 348-355.
24. Wood JC. Magnetic resonance imaging measurement of iron overload. Curr Opin Hematol 2007; 14: 183-190.