The mouse Muc5b mucin gene is transcriptionally regulated by thyroid transcription factor-1 (TTF-1) and GATA-6 transcription factors

FEBS Journal

Volumn 278, Issue 2, 2011, Pages 282-294

  Jonckheere, Nicolas ^a,b   Velghe, Amélie ^a   Ducourouble, Marie Paule ^a,b   Copin, Marie Christine ^a,b   Renes, Ingrid B ^c   Van Seuningen, Isabelle ^a,b  

^a JEAN PIERRE AUBERT RESEARCH CENTER   (France)

^b UNIV LILLE   (France)

^c SOPHIA CHILDREN S HOSPITAL   (Netherlands)

Author keywords

differentiation; GATA; Muc5b; mucin; TTF 1

Indexed keywords

MESSENGER RNA; MUCIN 5B; TATA BINDING PROTEIN; THYROID TRANSCRIPTION FACTOR 1; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR GATA 5; TRANSCRIPTION FACTOR GATA 6;

5' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING SITE; CELL DIFFERENTIATION; CONSENSUS SEQUENCE; CONTROLLED STUDY; DNA FLANKING REGION; ENZYME ACTIVITY; GC RICH SEQUENCE; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENE REPRESSION; IMMUNOHISTOCHEMISTRY; LUNG ADENOCARCINOMA; LUNG CARCINOGENESIS; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION;

MURINAE;

EID: 78651080912     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2010.07945.x     Document Type: Article

References (47)

1. Hollingsworth MA, &, Swanson BJ, (2004) Mucins in cancer: protection and control of the cell surface. Nat Rev Cancer 4, 45-60.
2. Dekker J, Rossen JW, Buller HA, &, Einerhand AW, (2002) The MUC family: an obituary. Trends Biochem Sci 27, 126-131.
3. Audie JP, Janin A, Porchet N, Copin MC, Gosselin B, &, Aubert JP, (1993) Expression of human mucin genes in respiratory, digestive, and reproductive tracts ascertained by in situ hybridization. J Histochem Cytochem 41, 1479-1485.
4. Chen Y, Zhao YH, Di YP, &, Wu R, (2001) Characterization of human mucin 5B gene expression in airway epithelium and the genomic clone of the amino-terminal and 5′-flanking region. Am J Respir Cell Mol Biol 25, 542-553.
5. Copin MC, Buisine MP, Devisme L, Leroy X, Escande F, Gosselin B, Aubert JP, &, Porchet N, (2001) Normal respiratory mucosa, precursor lesions and lung carcinomas: differential expression of human mucin genes. Front Biosci 6, D1264-D1275.
6. Jonckheere N, &, Van Seuningen I, (2010) The membrane-bound mucins: from cell signalling to transcriptional regulation and expression in epithelial cancers. Biochimie 92, 1-11.
7. Rose MC, &, Voynow JA, (2006) Respiratory tract mucin genes and mucin glycoproteins in health and disease. Physiol Rev 86, 245-278.
8. Buisine MP, Devisme L, Copin MC, Durand-Reville M, Gosselin B, Aubert JP, &, Porchet N, (1999) Developmental mucin gene expression in the human respiratory tract. Am J Respir Cell Mol Biol 20, 209-218.
9. Reid CJ, &, Harris A, (1998) Developmental expression of mucin genes in the human gastrointestinal system. Gut 42, 220-226.
10. Copin MC, Devisme L, Buisine MP, Marquette CH, Wurtz A, Aubert JP, Gosselin B, &, Porchet N, (2000) From normal respiratory mucosa to epidermoid carcinoma: expression of human mucin genes. Int J Cancer 86, 162-168.
11. Escande F, Porchet N, Aubert JP, &, Buisine MP, (2002) The mouse Muc5b mucin gene: cDNA and genomic structures, chromosomal localization and expression. Biochem J 363, 589-598.
12. Copin MC, Buisine MP, Leteurtre E, Marquette CH, Porte H, Aubert JP, Gosselin B, &, Porchet N, (2001) Mucinous bronchioloalveolar carcinomas display a specific pattern of mucin gene expression among primary lung adenocarcinomas. Hum Pathol 32, 274-281.
13. Van Seuningen I, Pigny P, Perrais M, Porchet N, &, Aubert JP, (2001) Transcriptional regulation of the 11p15 mucin genes. Towards new biological tools in human therapy, in inflammatory diseases and cancer? Front Biosci 6, D1216-D1234.
14. Mesquita P, Jonckheere N, Almeida R, Ducourouble MP, Serpa J, Silva E, Pigny P, Silva FS, Reis C, Silberg D, et al. (2003) Human MUC2 mucin gene is transcriptionally regulated by Cdx homeodomain proteins in gastrointestinal carcinoma cell lines. J Biol Chem 278, 51549-51556.
15. van der Sluis M, Melis MH, Jonckheere N, Ducourouble MP, Buller HA, Renes I, Einerhand AW, &, Van Seuningen I, (2004) The murine Muc2 mucin gene is transcriptionally regulated by the zinc-finger GATA-4 transcription factor in intestinal cells. Biochem Biophys Res Commun 325, 952-960.
16. Jonckheere N, Vincent A, Perrais M, Ducourouble MP, Male AK, Aubert JP, Pigny P, Carraway KL, Freund JN, Renes IB, et al. (2007) The human mucin MUC4 is transcriptionally regulated by caudal-related homeobox, hepatocyte nuclear factors, forkhead box A, and GATA endodermal transcription factors in epithelial cancer cells. J Biol Chem 282, 22638-22650.
17. Cardoso WV, (1995) Transcription factors and pattern formation in the developing lung. Am J Physiol 269, L429-L442.
18. Costa RH, Kalinichenko VV, &, Lim L, (2001) Transcription factors in mouse lung development and function. Am J Physiol Lung Cell Mol Physiol 280, L823-L838.
19. Kimura S, Hara Y, Pineau T, Fernandez-Salguero P, Fox CH, Ward JM, &, Gonzalez FJ, (1996) The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary. Genes Dev 10, 60-69.
20. Maeda Y, Dave V, &, Whitsett JA, (2007) Transcriptional control of lung morphogenesis. Physiol Rev 87, 219-244.
21. Liu C, Glasser SW, Wan H, &, Whitsett JA, (2002) GATA-6 and thyroid transcription factor-1 directly interact and regulate surfactant protein-C gene expression. J Biol Chem 277, 4519-4525.
22. Zhang L, Whitsett JA, &, Stripp BR, (1997) Regulation of Clara cell secretory protein gene transcription by thyroid transcription factor-1. Biochim Biophys Acta 1350, 359-367.
23. Ray MK, Chen CY, Schwartz RJ, &, DeMayo FJ, (1996) Transcriptional regulation of a mouse Clara cell-specific protein (mCC10) gene by the NKx transcription factor family members thyroid transcription factor 1 and cardiac muscle-specific homeobox protein (CSX). Mol Cell Biol 16, 2056-2064.
24. Copin MC, Perrais M, &, Van Seuningen I, (2008) Mucins in the pathophysiological lung. Expression and roles in immuno-and gene-based therapies. In The Epithelial Mucins: Structure/Function. Roles in Cancer and Inflammatory Diseases (, Van Seuningen I, ed), pp. 109-124. Research Signpost, Kerala.
25. Molkentin JD, (2000) The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene expression. J Biol Chem 275, 38949-38952.
26. Morrisey EE, Ip HS, Lu MM, &, Parmacek MS, (1996) GATA-6: a zinc finger transcription factor that is expressed in multiple cell lineages derived from lateral mesoderm. Dev Biol 177, 309-322.
27. Morrisey EE, Ip HS, Tang Z, Lu MM, &, Parmacek MS, (1997) GATA-5: a transcriptional activator expressed in a novel temporally and spatially-restricted pattern during embryonic development. Dev Biol 183, 21-36.
28. Weidenfeld J, Shu W, Zhang L, Millar SE, &, Morrisey EE, (2002) The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium. J Biol Chem 277, 21061-21070.
29. Van Seuningen I, Perrais M, Pigny P, Porchet N, &, Aubert JP, (2000) Sequence of the 5′-flanking region and promoter activity of the human mucin gene MUC5B in different phenotypes of colon cancer cells. Biochem J 348 (Pt 3), 675-686.
30. Tan D, Li Q, Deeb G, Ramnath N, Slocum HK, Brooks J, Cheney R, Wiseman S, Anderson T, &, Loewen G, (2003) Thyroid transcription factor-1 expression prevalence and its clinical implications in non-small cell lung cancer: a high-throughput tissue microarray and immunohistochemistry study. Hum Pathol 34, 597-604.
31. Yamazaki K, (2003) Pulmonary well-differentiated fetal adenocarcinoma expressing lineage-specific transcription factors (TTF-1 and GATA-6) to respiratory epithelial differentiation: an immunohistochemical and ultrastructural study. Virchows Arch 442, 393-399.
32. Jonckheere N, Van Der Sluis M, Velghe A, Buisine MP, Sutmuller M, Ducourouble MP, Pigny P, Buller HA, Aubert JP, Einerhand AW, et al. (2004) Transcriptional activation of the murine Muc5ac mucin gene in epithelial cancer cells by TGF-beta/Smad4 signalling pathway is potentiated by Sp1. Biochem J 377, 797-808.
33. Perrais M, Pigny P, Copin MC, Aubert JP, &, Van Seuningen I, (2002) Induction of MUC2 and MUC5AC mucins by factors of the epidermal growth factor (EGF) family is mediated by EGF receptor/Ras/Raf/extracellular signal-regulated kinase cascade and Sp1. J Biol Chem 277, 32258-32267.
34. Perrais M, Pigny P, Buisine MP, Porchet N, Aubert JP, &, Van Seuningen-Lempire I, (2001) Aberrant expression of human mucin gene MUC5B in gastric carcinoma and cancer cells. Identification and regulation of a distal promoter. J Biol Chem 276, 15386-15396.
35. Hackett B, Bingel C, &, Gitlin J, (1996) Mechanisms of gene expression and cell fate determination in the developing pulmonary epithelium. Annu Rev Physiol 58, 51-71.
36. Whitsett JA, (2002) Intrinsic and innate defenses in the lung: intersection of pathways regulating lung morphogenesis, host defense, and repair. J Clin Invest 109, 565-569.
37. Nakamura N, Miyagi E, Murata S, Kawaoi A, &, Katoh R, (2002) Expression of thyroid transcription factor-1 in normal and neoplastic lung tissues. Mod Pathol 15, 1058-1067.
38. Hovenberg HW, Davies JR, &, Carlstedt I, (1996) Different mucins are produced by the surface epithelium and the submucosa in human trachea: identification of MUC5AC as a major mucin from the goblet cells. Biochem J 318 (Pt 1), 319-324.
39. Zaret K, (1999) Developmental competence of the gut endoderm: genetic potentiation by GATA and HNF3/fork head proteins. Dev Biol 209, 1-10.
40. Guo M, Akiyama Y, House MG, Hooker CM, Heath E, Gabrielson E, Yang SC, Han Y, Baylin SB, Herman JG, et al. (2004) Hypermethylation of the GATA genes in lung cancer. Clin Cancer Res 10, 7917-7924.
41. Capo-chichi CD, Roland IH, Vanderveer L, Bao R, Yamagata T, Hirai H, Cohen C, Hamilton TC, Godwin AK, &, Xu XX, (2003) Anomalous expression of epithelial differentiation-determining GATA factors in ovarian tumorigenesis. Cancer Res 63, 4967-4977.
42. Ren CY, Akiyama Y, Miyake S, &, Yuasa Y, (2004) Transcription factor GATA-5 selectively up-regulates mucin gene expression. J Cancer Res Clin Oncol 130, 245-252.
43. Buisine MP, Porchet N, &, Van Seuningen I, (2008) Mucin expression and regulation during development and cell differentiation. In The Epithelial Mucins: Structure/Function. Roles in Cancer and Inflammatory Diseases (, Van Seuningen I, ed), pp 75-94. Research Signpost, Kerala.
44. Naltner A, Wert S, Whitsett JA, &, Yan C, (2000) Temporal/spatial expression of nuclear receptor coactivators in the mouse lung. Am J Physiol Lung Cell Mol Physiol 279, L1066-L1074.
45. Yang H, Lu MM, Zhang L, Whitsett JA, &, Morrisey EE, (2002) GATA6 regulates differentiation of distal lung epithelium. Development 129, 2233-2246.
46. Van Seuningen I, Ostrowski J, Bustelo XR, Sleath PR, &, Bomsztyk K, (1995) The K protein domain that recruits the interleukin 1-responsive K protein kinase lies adjacent to a cluster of c-Src and Vav SH3-binding sites. Implications that K protein acts as a docking platform. J Biol Chem 270, 26976-26985.
47. Piessen G, Jonckheere N, Vincent A, Hemon B, Ducourouble MP, Copin MC, Mariette C, &, Van Seuningen I, (2007) Regulation of the human mucin MUC4 by taurodeoxycholic and taurochenodeoxycholic bile acids in oesophageal cancer cells is mediated by hepatocyte nuclear factor 1alpha. Biochem J 402, 81-91.