The effects of intravenous calcium in patients with digoxin toxicity

Journal of Emergency Medicine

Volumn 40, Issue 1, 2011, Pages 41-46

  Levine, Michael ^a   Nikkanen, Heikki ^b,c   Pallin, Daniel J ^b  

^a BANNER GOOD SAMARITAN MEDICAL CENTER   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

calcium; digoxin; digoxin toxicity; hyperkalemia

Indexed keywords

CALCIUM CHLORIDE; GLUCONATE CALCIUM;

ADULT; AGE DISTRIBUTION; ARTICLE; CREATININE BLOOD LEVEL; DIGITALIS INTOXICATION; DRUG FATALITY; HEART ARRHYTHMIA; HUMAN; HYPERKALEMIA; MAJOR CLINICAL STUDY; POTASSIUM BLOOD LEVEL; PRIORITY JOURNAL; SYSTOLIC BLOOD PRESSURE;

AGED; ARRHYTHMIAS, CARDIAC; CALCIUM; DIGOXIN; HUMANS; HYPERKALEMIA; INJECTIONS, INTRAVENOUS; TREATMENT OUTCOME;

EID: 78651077306     PISSN: 07364679     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jemermed.2008.09.027     Document Type: Article

References (23)

1. th edn. 2006 McGraw-Hill Companies, Inc New York 869 897
2. P.J. Haupman, and R.A. Kelly Digitalis Circulation 99 1999 1265 1270
3. th edn. 2002 McGraw-Hill Companies, Inc New York 724 740
4. J.B. Hack, J.H. Woody, and D.E. Lewis The effect of calcium chloride in treating hyperkalemia due to acute digoxin toxicity in a porcine model Clin Toxicol 42 2004 337 342
5. T.C. Bania, B. Blaufeux, and S. Hughes Calcium and digoxin vs. calcium alone for severe verapamil toxicity Acad Emerg Med 7 2000 1089 1096
6. R.A. Kelly, and T.W. Smith Recognition and management of digitalis toxicity Am J Cardiol 69 1992 108 109
7. A. Caprio, and A. Farah The effect of the ionic milieu on the response of rabbit cardiac muscle to ouabain J Pharmacol Exp Ther 155 1967 403 414
8. J.O. Bower, and H.A.K. Mengle The additive effect of calcium and digitalis: a warning, with a report of two deaths JAMA 106 1936 1511 1553
9. H. Gold, and D.J. Edwards The effects of aubain on the heart in the presence of hypercalcemia Am Heart J 3 1927 45 50
10. A.L. Lieberman Some inter-relationships of the cardiac activities of calcium gluconate and scilaren-B J Pharmacol Exp Ther 47 1933 183 192
11. P.K. Smith, A.W. Winkler, and H.E. Hoff Calcium and digitalis synergism: the toxicity of calcium salts injected intravenously into digitalized animals Arch Intern Med 64 1939 322 329
12. G.T. Nola, S. Pope, and D.C. Harrison Assessment of the synergistic relationship between serum calcium and digitalis Am Heart J 79 1970 499 507
13. M.W. Shrager Digitalis intoxication Arch Intern Med 100 1957 881 893
14. T. Kne, M. Brokaw, and P. Wax Fatality from calcium chloride in a chronic digoxin toxic patient J Toxicol Clin Toxicol 5 1997 505
15. F. Fenton, A.J. Smally, and J. Laut Hyperkalemia and digoxin toxicity in a patient with kidney failure Ann Emerg Med 28 1996 440 441
16. S.K. Van Deusen, R.H. Birkhahn, and T.J. Gaeta Treatment of hyperkalemia in a patient with unrecognized digitalis toxicity J Toxicol Clin Toxicol 41 2003 373 376
17. B. Lown, H. Black, and F.D. Moore Digitalis, electrolytes, and the surgical patient Am J Cardiol 6 1960 309 337
18. E.M. Antman, T.L. Wenger, and V.P. Butler Treatment of 150 cases of life-threatening digitalis intoxication with digoxin-specific fab antibody fragments Final report of a multicenter study Circulation 81 1990 1744 1752
19. G.A. Beller, T.W. Smith, and W.H. Abelmann Digitalis intoxication: a prospective clinical study with serum level correlations N Engl J Med 284 1971 989 997
20. H. Mahdyoon, G. Battilana, and H. Rosman The evolving pattern of digoxin intoxication: observations at a large urban hospital from 1980 to 1988 Am Heart J 120 1990 1189 1194
21. C. Bismuth, M. Gaultier, and F. Conso Hyperkalemia in acute digitalis poisoning: prognostic significance and therapeutic implications Clin Toxicol 6 1973 152 162
22. J. Brubacher, D. Lachmanen, and R.P. Ravikumar Efficacy of digoxin specific Fab fragments (Digibind) in the treatment of toad venom poisoning Toxicon 37 1999 931 942
23. J. Brubacher, P. Ravikumar, and T. Bania Treatment of toad venom poisoning with digoxin-specific Fab fragments Chest 110 1996 1282 1288