Synthesis and antiviral evaluation of thieno[3,4-d]pyrimidine C-nucleoside analogues of 2′,3′-dideoxy- and 2′,3′-dideoxy-2′,3′-didehydro-adenosine and -inosine

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 6, 2009, Pages 2321-2326

  Hamann, Marie ^a   Pierra, Claire ^a   Sommadossi, Jean Pierre ^b   Musiu, Chiara ^c   Vargiu, Luana ^c   Liuzzi, Michel ^c   Storer, Richard ^a   Gosselin, Gilles ^a  

^a Cap Gamma   (France)

^b Idenix Pharmaceuticals Inc   (United States)

^c UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

2 ,3 Dideoxy C nucleoside analogues; 7,9 Dideaza 8 thiapurine series; Antiviral evaluation; HIV 1; NRTI; Synthesis

Indexed keywords

2',3' DIDEHYDRO 2',3' DIDEOXYADENOSINE; 2',3' DIDEOXY 2',3' DIDEHYDROINOSINE; 2',3' DIDEOXYADENOSINE; DIDANOSINE; INOSINE DERIVATIVE; NUCLEOSIDE DERIVATIVE; PYRIMIDINE DERIVATIVE; THIENO[3,4 D]PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; NONHUMAN; REACTION ANALYSIS; STRUCTURE ANALYSIS;

ADENOSINE; ANTIVIRAL AGENTS; HIV; INOSINE; MAGNETIC RESONANCE SPECTROSCOPY; PYRIMIDINES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 62549146633     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.02.011     Document Type: Article

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