A randomized double-blind controlled trial of phosphorylcholine-coated tympanostomy tube versus standard tympanostomy tube in children with recurrent acute and chronic otitis media

Laryngoscope

Volumn 121, Issue 1, 2011, Pages 214-219

  Hong, Paul ^a   Smith, Neil ^b   Johnson, Liane B ^a   Corsten, Gerard ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

^b Woodlawn ENT Associates   (Canada)

Author keywords

Level of Evidence: 1b; Phosphorylcholine coating; tube otorrhea; tympanostomy tube; tympanostomy tube complications; tympanostomy tube extrusion

Indexed keywords

PHOSPHORYLCHOLINE;

ACUTE OTITIS MEDIA; ARTICLE; CHILD; CHRONIC OTITIS MEDIA; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; INFANT; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; OTITIS MEDIA; OTORRHEA; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; TREATMENT FAILURE; TREATMENT OUTCOME; TYMPANOSTOMY TUBE;

ACUTE DISEASE; CHILD; CHILD, PRESCHOOL; CHRONIC DISEASE; COATED MATERIALS, BIOCOMPATIBLE; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INFANT; MALE; MIDDLE EAR VENTILATION; OTITIS MEDIA; OTITIS MEDIA WITH EFFUSION; PHOSPHORYLCHOLINE; RECURRENCE;

EID: 78651059804     PISSN: 0023852X     EISSN: None     Source Type: Journal    
DOI: 10.1002/lary.21156     Document Type: Article

References (35)

1. Kogan MD, Overpeck MD, Hoffman HJ, Casselbrant ML., Factors associated with tympanostomy tube insertion among preschool-aged children in the United States. Am J Public Health 2000; 90: 245-250.
2. Rosenfeld RM, Bahaya MH, Bower CM, et al. Impact of tympanostomy tubes on child quality of life. Arch Otolaryngol Head Neck Surg 2000; 126: 585-592.
3. Armstrong BW., A new treatment for chronic secretory otitis media. Arch Otolaryngol 1954; 59: 653-654.
4. House HP., Polyethylene in middle ear surgery. Arch Otolaryngol 1960; 71: 926-931.
5. Donaldson JA., The role of artificial eustachian tube in cleft palate patients. Cleft Palate J 1966; 3: 61-66.
6. Reuter H., The stainless steel Bobbin middle ear ventilation tube. Trans Am Acad Ophthalmol Otolaryngol 1968; 76: 1017-1019.
7. Silverstein H., Malleus clip tube for long-term equalization of middle ear pressure. Trans Am Acad Ophthalmol Otolaryngol 1966; 70: 640-642.
8. Goode RL., T-tube for middle ear ventilation. Arch Oto Laryngol 1973; 97: 402-403.
9. Chole RA, Hubbell RN., Antimicrobial activity of silastic tympanostomy tubes impregnanted with silver oxide. A double-blind randomized multicenter trial. Arch Otolaryngol Head Neck Surg 1995; 121: 562-565.
10. Tami TA, Kennedy KS, Harley E., A clinical evaluation of gold-plated tubes for middle-ear ventilation. Arch Otolaryngol Head Neck Surg 1987; 113: 979-980.
11. Kinnari TJ, Rihkanen H, Laine T, Salonen EM, Jero J., Role of albumin coating of tympanostomy tubes: a long-term clinical evaluation. Laryngoscope 2007; 117: 2213-2217.
12. Berry JA, Biedlingmaier JF, Whelan PJ., In vitro resistance to bacterial biofilm formation on coated fluoroplastic tympanostomy tubes. Otolaryngol Head Neck Surg 2000; 123: 246-251.
13. Licameli G, Johnston P, Luz J, Daley J, Kenna M., Phosphorylcholine- coated antibiotic tympanostomy tubes: are post-tube placement complications reduced? Int J Pediatr Otorhinolaryngol 2008; 72: 1323-1328.
14. Per-Lee JH., Long-term middle ear ventilation. Laryngoscope 1981; 91: 1063-1673.
15. Armstrong BW., Prolonged middle ear ventilation: the right tube in the right place. Ann Otol Rhinol Laryngol 1983; 92: 582-586.
16. Shinkwin CA, Murty GE, Simo R, Jones NS., Per-operative antibiotic/steroid prophylaxis of tympanostomy tube otorrhoea: chemical or mechanical effect? J Laryngol Otol 1996; 110: 531-533.
17. Younis RT, Lazar RH, Long TE., Ventilation tubes and prophylactic antibiotic ear-drops. Otolaryngol Head Neck Surg 1992; 106: 193-195.
18. Salam MA, Cable HR., The use of antibiotic/steroid drops to reduce postoperative otorrhea and blockage of ventilation tubes. J Laryngol Otol 1993; 107: 188-189.
19. Giebink SG, Daly K, Buran DJ, Satz M, Ayre T., Predictors for postoperative otorrhea following tympanostomy tube insertion. Arch Otolaryngol Head Neck Surg 1992; 118: 491-494.
20. Vaile L, Williamson T, Waddell A, Taylor G., Interventions for ear discharge associated with grommets (ventilation tubes). Cochrane Database Syst Rev 2006; 19: CD001933.
21. Hester TO, Jones RO, Archer SM, Haydon RC., Prophylactic antibiotic drops after tympanostomy tube placement. Arch Otolaryngol Head Neck Surg 1995; 121: 445-448.
22. Welling DB, Forrest LA, Goll F., Safety of ototopical antibiotics. Laryngoscope 1995; 105: 472-474.
23. Epstein JS, Beane J, Hubbell RN., Prevention of early otorrhea in ventilation tubes. Otolaryngol Head Neck Surg 1992; 107: 758-762.
24. Isaacson G, Rosenfeld RM., Care of the child with tympanostomy tubes. Pediatr Clin North Am 1996; 43: 1183-1192.
25. Balkany TH, Barkin RM, Suzuki BH, Watson WJ., A prospective study of infection following tympanostomy and tube insertion. Am J Otol 1983; 4: 288-291.
26. Ruohola A, Heikkinen T, Meurman O, et al. Antibiotic treatment of acute otorrhea through tympanostomy tube: randomized doubleb-blind placebo-controlled study with daily follow-up. Pediatrics 2003; 111: 1061-1067.
27. Bothwell MR, Smith AL, Phillips T., Recalcitrant otorrhea due to Pseudomonas biofilm. Otolaryngol Head Neck Surg 2003; 129: 599-601.
28. Ehrlich GD, Veeh R, Wand X, et al. Mucosal biofilm formation on middle-ear mucosa in the chinchilla model of otitis media. JAMA 2002; 287: 1710-1715.
29. Saidi IS, Biedlingmaier JF, Whelan P., In vivo resistance to bacterial biofilm formation on tympanostomy tubes as a function of tube material. Otolaryngol Head Neck Surg 1999; 120: 621-627.
30. Handler SD, Potsic WP, Marsh RR., A trial of Biolite ventilation tubes in children: is further use warranted? Otolaryngol Head Neck Surg 1983; 91: 437-440.
31. Uneri C, Sari M, Akboga J, Yuksel M., Vitamin E-coated tympanostomy tube insertion decreases the quantity of free radicals in tympanic membrane. Laryngoscope 2006; 116: 140-143.
32. Mandel E, Casselbrant ML, Kurs-Lasky M., Acute otorrhea: bacteriology of a common complication of tympanostomy tubes. Ann Otol Rhinol Laryngol 1994; 103: 713-718.
33. Tsao BA, Stevens GR, Antonelli PJ., Opening plugged tympanostomy tubes: effect of tube composition. Otolaryngol Head Neck Surg 2003; 128: 870-874.
34. Kay DJ, Nelson M, Rosenfeld RM., Meta-analysis of tympanostomy tube sequelae. Otolaryngol Head Neck Surg 2001; 124: 374-380.
35. Evans AY, Cunningham MJ., Other complications of tympanostomy tubes. In:, Alper C, Bluestone C, Casselbrant M, Dohar J, Mandel E, (eds). Advanced Therapy of Otitis Media. Hamilton, Ontario: BC Decker Inc.; 2004; 281-286.