Reduced respiratory capacity in muscle mitochondria of obese subjects

Obesity Facts

Volumn 3, Issue 6, 2010, Pages 371-375

  Bakkman, Linda ^a   Fernström, Maria ^a   Loogna, Peter ^b   Rooyackers, Olav ^a   Brandt, Lena ^a   Lagerros, Ylva Trolle ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b Sophiahemmet   (Sweden)

Author keywords

Metabolism; Muscle mitochondria; Obesity; Resting energy expenditure; Thermogenesis

Indexed keywords

PYRUVIC ACID;

ADULT; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; METABOLIC CAPACITY; MITOCHONDRIAL RESPIRATION; MITOCHONDRIAL VOLUME; MUSCLE BIOPSY; MUSCLE MITOCHONDRION; OBESITY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; VASTUS LATERALIS MUSCLE;

ADULT; BIOPSY; BODY MASS INDEX; CASE-CONTROL STUDIES; CELL RESPIRATION; ENERGY METABOLISM; EXERCISE; FEMALE; GASTRIC BYPASS; HUMANS; MALE; MITOCHONDRIA, MUSCLE; OBESITY; OXIDATION-REDUCTION; OXYGEN CONSUMPTION; PYRUVIC ACID; QUADRICEPS MUSCLE; YOUNG ADULT;

EID: 78650961488     PISSN: 16624025     EISSN: 16624033     Source Type: Journal    
DOI: 10.1159/000320167     Document Type: Article

References (31)

1. Sims EA, Danforth E Jr, Horton ES, Bray GA, Glennon JA, Salans LB: Endocrine and metabolic effects of experimental obesity in man. Recent Prog Horm Res 1973;29:457-496.
2. Goele K, Bosy-Westphal A, Rumcker B, Lager-pusch M, Muller MJ: Influence of changes in body composition and adaptive thermogenesis on the difference between measured and predicted weight loss in obese women. Obes Facts 2009;2:105-109.
3. Joosen AM, Westerterp KR: Energy expenditure during overfeeding. Nutr Metab (Lond) 2006;3:25.
4. McArdle W: Exercise Physiology, ed 2. Philadelphia, Lea & Febiger, 1986.
5. Zurlo F, Larson K, Bogardus C, Ravussin E: Skeletal muscle metabolism is a major determinant of resting energy expenditure. J Clin Invest 1990;86: 1423-1427.
6. Lowell BB, Shulman GI: Mitochondrial dysfunction and type 2 diabetes. Science 2005;307:384-387.
7. Fleischman A, Kron M, Systrom DM, Hrovat M, Grinspoon SK: Mitochondrial function and insulin resistance in overweight and normal-weight children. J Clin Endocrinol Metab 2009;94:4923-4930.
8. Rolfe DF, Brand MD: Contribution of mitochon-drial proton leak to skeletal muscle respiration and to standard metabolic rate. Am J Physiol 1996;271: C1380-1389.
9. Bass A, Vondra K, Rath R, Vitek V, Havranek T: Metabolic changes in the quadriceps femoris muscle of obese people. Enzyme activity patterns of energy-supplying metabolism. Pflugers Arch 1975; 359:325-334.
10. Kelley DE, He J, Menshikova EV, Ritov VB: Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 2002;51:2944-2950.
11. Kim JY, Hickner RC, Cortright RL, Dohm GL, Houmard JA: Lipid oxidation is reduced in obese human skeletal muscle. Am J Physiol Endocrinol Metab 2000;279:E1039-1044.
12. Simoneau JA, Colberg SR, Thaete FL, Kelley DE: Skeletal muscle glycolytic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese women. Faseb J 1995;9:273-278.
13. Fernstrom M, Tonkonogi M, Sahlin K: Effects of acute and chronic endurance exercise on mito-chondrial uncoupling in human skeletal muscle. J Physiol 2004;554:755-763.
14. Fernstrom M, Bakkman L, Tonkonogi M, Shaba-lina IG, Rozhdestvenskaya Z, Mattsson CM, En-qvist JK, Ekblom B, Sahlin K: Reduced efficiency, but increased fat oxidation, in mitochondria from human skeletal muscle after 24-h ultraendurance exercise. J Appl Physiol 2007;102:1844-1849.
15. Bergstrom J: Percutaneous needle biopsy of skeletal muscle in physiological and clinical research. Scand J Clin Lab Invest 1975;35:609-616.
16. Tonkonogi M, Sahlin K: Rate of oxidative phos-phorylation in isolated mitochondria from human skeletal muscle: effect of training status. Acta Phys-iol Scand 1997;161:345-353.
17. Chance B, Williams GR: Respiratory enzymes in oxidative phosphorylation. I. Kinetics of oxygen utilization. J Biol Chem 1955;217:383-393.
18. Tonkonogi M, Harris B, Sahlin K: Increased activity of citrate synthase in human skeletal muscle after a single bout of prolonged exercise. Acta Physiol Scand 1997;161:435-436.
19. Wade AJ, Marbut MM, Round JM: Muscle fibre type and aetiology of obesity. Lancet 1990;335:805-808.
20. Saltin B, Gollnick PD: Handbook of physiology. Skeletal muscle. Bethesda, MD, American Physiological Society, 1983.
21. Hood DA: Invited review: Contractile activity-induced mitochondrial biogenesis in skeletal muscle. J Appl Physiol 2001;90:1137-1157.
22. Shulman GI: Cellular mechanisms of insulin resistance. J Clin Invest 2000;106:171-176.
23. Melanson EL, Astrup A, Donahoo WT: The relationship between dietary fat and fatty acid intake and body weight, diabetes, and the metabolic syndrome. Ann Nutr Metab 2009;55:229-243.
24. Rasmussen BB, Wolfe RR: Regulation of fatty acid oxidation in skeletal muscle. Annu Rev Nutr 1999; 19:463-484.
25. Simoneau JA, Veerkamp JH, Turcotte LP, Kel-ley DE: Markers of capacity to utilize fatty acids in human skeletal muscle: relation to insulin resistance and obesity and effects of weight loss. Faseb J 1999;13:2051-2060.
26. Holloway GP, Thrush AB, Heigenhauser GJ, Tan-don NN, Dyck DJ, Bonen A, Spriet LL: Skeletal muscle mitochondrial fat/cd36 content and palmi-tate oxidation are not decreased in obese women. Am J Physiol Endocrinol Metab 2007;292:E1782- 1789.
27. Rogge MM: The role of impaired mitochondrial lipid oxidation in obesity. Biol Res Nurs 2009;10: 356-373.
28. Tudor-Locke C, Bassett DR Jr: How many steps/ day are enough? Preliminary pedometer indices for public health. Sports Med 2004;34:1-8.
29. Tonkonogi M, Fernstrom M, Walsh B, Ji LL, Rooyackers O, Hammarqvist F, Wernerman J, Sahlin K: Reduced oxidative power but unchanged antioxidative capacity in skeletal muscle from aged humans. Pflugers Arch 2003;446:261-269.
30. Trounce I, Byrne E, Marzuki S: Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in ageing. Lancet 1989;1:637-639.
31. Petersen KF, Befroy D, Dufour S, Dziura J, Ariyan C, Rothman DL, DiPietro L, Cline GW, Shulman GI: Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science 2003;300: 1140-1142.