Recent advances in the pathophysiology of Parkinson's disease: Evidence from fMRI and TMS studies

Experimental Neurology

Volumn 227, Issue 1, 2011, Pages 10-12

  Berardelli, Alfredo ^a   Suppa, Antonio ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Functional magnetic resonance; Parkinson's disease; Transcranial magnetic stimulation

Indexed keywords

BRADYKINESIA; DISEASE SEVERITY; DOPAMINERGIC NERVE CELL; EXCITABILITY; FACILITATION; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; LONG TERM DEPRESSION; MOTOR CORTEX; NERVE CELL DEGENERATION; NERVE CELL PLASTICITY; NOTE; PARKINSON DISEASE; PARKINSONISM; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SENSORIMOTOR CORTEX; TRANSCRANIAL MAGNETIC STIMULATION;

ELECTROMYOGRAPHY; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; OXYGEN; PARKINSON DISEASE; TRANSCRANIAL MAGNETIC STIMULATION;

EID: 78650944113     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2010.09.014     Document Type: Note

References (25)

1. Bagnato S., Agostino R., Modugno N., Quartarone A., Berardelli A. Plasticity of the motor cortex in Parkinson's disease patients on and off therapy. Mov. Disord. 2006, 21:639-645.
2. Berardelli A., Rona S., Inghilleri M., Manfredi M. Cortical inhibition in Parkinson's disease. A study with paired magnetic stimulation. Brain 1996, 119:71-77.
3. Berardelli A., Inghilleri M., Rothwell J.C., Romeo S., Curra A., Gilio F., Modugno N., Manfredi M. Facilitation of muscle evoked responses after repetitive cortical stimulation in man. Exp. Brain Res. 1998, 122:79-84.
4. Berardelli A., Rothwell J.C., Thompson P.D., Hallett M. Pathophysiology of bradykinesia in Parkinson's disease. Brain 2001, 124:2131-2146.
5. Berardelli A., Abbruzzese G., Chen R., Orth M., Ridding M.C., Stinear C., Suppa A., Trompetto C., Thompson P.D. Consensus paper on short-interval intracortical inhibition and other transcranial magnetic stimulation intracortical paradigms in movement disorders. Brain Stimul. 2008, 1:183-191.
6. Buhmann C., Glauche V., Sturenburg H.J., Oechsner M., Weiller C., Buchel C. Pharmacologically modulated fMRI cortical responsiveness to levodopa in drug-naive hemiparkinsonian patients. Brain 2003, 126:451-461.
7. Buhmann C., Gorsler A., Baumer T., Hidding U., Demiralay C., Hinkelmann K., Weiller C., Siebner H.R., Münchau A. Abnormal excitability of premotor-motor connections in de novo Parkinson's disease. Brain 2004, 127:2732-2746.
8. Cerasa A., Hagberg G.E., Peppe A., Bianciardi M., Gioia M.C., Costa A., Castriota-Scandeberg A., Caltagirone C., Sabatini U. Functional changes in the activity of cerebellum and frontostriatal regions during externally and internally timed movement in Parkinson's disease. Brain Res. Bull. 2006, 71:259-269.
9. Chen R., Cros D., Curra A., Di Lazzaro V., Lefaucheur J.P., Magistris M.R., Mills K., Rösler K.M., Triggs W.J., Ugawa Y., Ziemann U. The clinical diagnostic utility of transcranial magnetic stimulation: report of an IFCN committee. Clin. Neurophysiol. 2008, 119:504-532.
10. DeLong M.R., Wichmann T. Circuits and circuit disorders of the basal ganglia. Arch. Neurol. 2007, 64:20-24.
11. Eckert T., Peschel T., Heinze H.J., Rotte M. Increased pre-SMA activation in early PD patients during simple self-initiated hand movements. J. Neurol. 2006, 253:199-207.
12. Eggers C., Fink G.R., Nowak D.A. Theta burst stimulation over the primary motor cortex does not induce cortical plasticity in Parkinson's disease. J. Neurol 2010, 257:1669-1674.
13. Gilio F., Curra A., Inghilleri M., Lorenzano C., Manfredi M., Berardelli A. Repetitive magnetic stimulation of cortical motor areas in Parkinson's disease: implications for the pathophysiology of cortical function. Mov. Disord. 2002, 17:467-473.
14. Haslinger B., Erhard P., Kampfe N., Boecker H., Rummeny E., Schwaiger M., Conrad B., Ceballos-Baumann A.O. Event-related functional magnetic resonance imaging in Parkinson's disease before and after levodopa. Brain 2001, 124:558-570.
15. Huang Y.Z., Edwards M.J., Rounis E., Bhatia K.P., Rothwell J.C. Theta burst stimulation of the human motor cortex. Neuron 2005, 45:201-206.
16. Mir P., Matsunaga K., Gilio F., Quinn N.P., Siebner H.R., Rothwell J.C. Dopaminergic drugs restore facilitatory premotor-motor interactions in Parkinson's disease. Neurology 2005, 64:1906-1912.
17. Morgante F., Espay A.J., Gunraj C., Lang A.E., Chen R. Motor cortex plasticity in Parkinson's disease and levodopa-induced dyskinesias. Brain 2006, 129:1059-1069.
18. Ridding M.C., Inzelberg R., Rothwell J.C. Changes in excitability of motor cortical circuitry in patients with Parkinson's disease. Ann. Neurol. 1995, 37:181-188.
19. Rowe J., Stephan K.E., Friston K., Frackowiak R., Lees A., Passingham R. Attention to action in Parkinson's disease: impaired effective connectivity among frontal cortical regions. Brain 2002, 125:276-289.
20. Sabatini U., Boulanouar K., Fabre N., Martin F., Carel C., Colonnese C., Bozzao L., Berry I., Montastruc J.L., Chollet F., Rascol O. Cortical motor reorganization in akinetic patients with Parkinson's disease: a functional MRI study. Brain 2000, 123:394-403.
21. Stefan K., Kunesch E., Cohen L.G., Benecke R., Classen J. Induction of plasticity in the human motor cortex by paired associative stimulation. Brain 2000, 123:572-584.
22. Suppa A., Iezzi E., Conte A., Belvisi D., Marsili L., Modugno N., Fabbrini G., Berardelli A. Dopamine influences primary motor cortex plasticity and dorsal premotor-to-motor connectivity in Parkinson's disease. Cereb. Cortex 2010, 20(9):2224-2233.
23. Tessa C., Lucetti C., Diciotti S., Baldacci F., Paoli L., Cecchi P., Giannelli M., Ginestroni A., Del Dotto P., Ceravolo R., Vignali C., Bonuccelli U., Mascalchi M. Decreased and increased cortical activation coexist in de novo Parkinson's disease. Exp. Neurol. 2010, 224:299-306.
24. Ueki Y., Mima T., Ali Kotb M., Sawada H., Saiki H., Ikeda A., Begum T., Reza F., Nagamine T., Fukuyama H. Altered plasticity of the human motor cortex in Parkinson's disease. Ann. Neurol. 2006, 59:60-71.
25. Yu H., Sternad D., Corcos D.M., Vaillancourt D.E. Role of hyperactive cerebellum and motor cortex in Parkinson's disease. Neuroimage 2007, 35:222-233.