Deletion of the mouse homolog of KCNAB2, a gene linked to monosomy 1p36, results in associative memory impairments and amygdala hyperexcitability

Journal of Neuroscience

Volumn 31, Issue 1, 2011, Pages 46-54

  Perkowski, John J ^a   Murphy, Geoffrey G ^a,b,c  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VOLTAGE GATED POTASSIUM CHANNEL;

AFTERHYPERPOLARIZATION; AMYGDALOID NUCLEUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EVOKED BRAIN STEM AUDITORY RESPONSE; FEMALE; GENE DELETION; GENE MAPPING; LEARNING DISORDER; MALE; MEMORY DISORDER; MONOSOMY; NERVE CELL; NERVE CELL EXCITABILITY; NERVE POTENTIAL; NONHUMAN; PRIORITY JOURNAL;

ACOUSTIC STIMULATION; AMYGDALA; ANALYSIS OF VARIANCE; ANIMALS; ASSOCIATION LEARNING; BEHAVIOR, ANIMAL; CONDITIONING, CLASSICAL; ELECTRIC STIMULATION; ELECTROENCEPHALOGRAPHY; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; EXPLORATORY BEHAVIOR; FEAR; MEMBRANE POTENTIALS; MEMORY DISORDERS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURONS; PATCH-CLAMP TECHNIQUES; PHENYLALANINE; POINT MUTATION; SHAKER SUPERFAMILY OF POTASSIUM CHANNELS; TYROSINE;

EID: 78650884359     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2634-10.2011     Document Type: Article

References (36)

1. Boettcher FA (2002) Presbyacusis and the auditory brainstem response. J Speech Lang Hear Res 45:1249-1261.
2. Brunzell DH, Coy AE, Ayres JJ, Meyer JS (2002) Prenatal cocaine effects on fear conditioning: exaggeration of sex-dependent context extinction. Neurotoxicol Teratol 24:161-172.
3. Connor JX, McCormack K, Pletsch A, Gaeta S, Ganetzky B, Chiu SY, Messing A (2005) Genetic modifiers of the Kv beta2-null phenotype in mice. Genes Brain Behav 4:77-88.
4. D'Angelo CS, Da Paz JA, Kim CA, Bertola DR, Castro CI, Varela MC, Koiffmann CP (2006) Prader-Willi-like phenotype: investigation of 1p36 deletion in 41 patients with delayed psychomotor development, hypotonia, obesity and/or hyperphagia, learning disabilities and behavioral problems. Eur J Med Genet 49:451-460.
5. Daoudal G, Debanne D (2003) Long-term plasticity of intrinsic excitability: learning rules and mechanisms. Learn Mem 10:456-465.
6. Faber ES, Sah P (2002) Physiological role of calcium-activated potassium currents in the rat lateral amygdala. J Neurosci 22:1618-1628.
7. + (BK) channel inactivation contributes to spike broadening during repetitive firing in the rat lateral amygdala. J Physiol 552:483-497.
8. Faber ES, Sah P (2003b) Calcium-activated potassium channels: multiple contributions to neuronal function. Neuroscientist 9:181-194.
9. Faber ES, Sah P (2004) Opioids inhibit lateral amygdala pyramidal neurons by enhancing a dendritic potassium current. J Neurosci 24:3031-3039.
10. Faber ES, Sah P (2005) Independent roles of calcium and voltage-dependent potassium currents in controlling spike frequency adaptation in lateral amygdala pyramidal neurons. Eur J Neurosci 22:1627-1635.
11. Gajecka M, Mackay KL, Shaffer LG (2007) Monosomy 1p36 deletion syndrome. Am J Med Genet C Semin Med Genet 145C:346-356.
12. + channel inactivation, spike broadening, and after-hyperpolarization in Kvbeta1.1-deficient mice with impaired learning. Learn Mem 5:257-273.
13. Giese KP, Peters M, Vernon J (2001) Modulation of excitability as a learning and memory mechanism: a molecular genetic perspective. Physiol Behav 73:803-810.
14. Goosens KA, Hobin JA, Maren S (2003) Auditory-evoked spike firing in the lateral amygdala and Pavlovian fear conditioning: mnemonic code or fear bias? Neuron 40:1013-1022.
15. Heilstedt HA, Burgess DL, Anderson AE, Chedrawi A, Tharp B, Lee O, Kashork CD, Starkey DE, Wu YQ, Noebels JL, Shaffer LG, Shapira SK (2001) Loss of the potassium channel beta-subunit gene, KCNAB2, is associated with epilepsy in patients with 1p36 deletion syndrome. Epilepsia 42:1103-1111.
16. Heilstedt HA, Ballif BC, Howard LA, Lewis RA, Stal S, Kashork CD, Bacino CA, Shapira SK, Shaffer LG (2003) Physical map of 1p36, placement of breakpoints in monosomy 1p36, and clinical characterization of the syndrome. Am J Hum Genet 72:1200-1212.
17. Kurosawa K, Kawame H, Okamoto N, Ochiai Y, Akatsuka A, Kobayashi M, Shimohira M, Mizuno S, Wada K, Fukushima Y, Kawawaki H, Yamamoto T, Masuno M, Imaizumi K, Kuroki Y (2005) Epilepsy and neurological findings in 11 individuals with 1p36 deletion syndrome. Brain Dev 27:378-382.
18. Matthews EA, Disterhoft JF (2009) Blocking the BK channel impedes acquisition of trace eyeblink conditioning. Learn Mem 16:106-109.
19. + channel beta 1 gene and functional expression of the beta 2 gene product. FEBS Lett 370:32-36.
20. + channel β subunit Kvbeta 2 (Kcnab2). J Biol Chem 277:13219-13228.
21. + channel beta subunits belong to an NAD(P)H-dependent oxidoreductase superfamily. Cell 79:1133-1135.
22. McKinney BC, Murphy GG (2006) The L-Type voltage-gated calcium channel Cav1.3 mediates consolidation, but not extinction, of contextually conditioned fear in mice. Learn Mem 13:584-589.
23. McKinney BC, Schneider JS, Schafer GL, Lowing JL, Mohan S, Zhao MX, Heng MY, Albin RL, Seasholtz AF, Akil H, Murphy GG (2008a) Decreased locomotor activity in mice expressing tTA under control of the CaMKII alpha promoter. Genes Brain Behav 7:203-213.
24. McKinney BC, Chow CY, Meisler MH, Murphy GG (2008b) Exaggerated emotional behavior in mice heterozygous null for the sodium channel Scn8a (NaV1.6). Genes Brain Behav 7:629-638.
25. Murphy GG, Fedorov NB, Giese KP, Ohno M, Friedman E, Chen R, Silva AJ (2004) Increased neuronal excitability, synaptic plasticity, and learning in aged Kvbeta1.1 knockout mice. Curr Biol 14:1907-1915.
26. + channels. Biochem J 257:899-903.
27. Quirk GJ, Repa C, LeDoux JE (1995) Fear conditioning enhances shortlatency auditory responses of lateral amygdala neurons: parallel recordings in the freely behaving rat. Neuron 15:1029-1039.
28. Quirk GJ, Armony JL, LeDoux JE (1997) Fear conditioning enhances different temporal components of tone-evoked spike trains in auditory cortex and lateral amygdala. Neuron 19:613-624.
29. Sanders MJ, Kieffer BL, Fanselow MS (2005) Deletion of the mu opioid receptor results in impaired acquisition of Pavlovian context fear. Neurobiol Learn Mem 84:33-41.
30. + channel surface expression through effects early in biosynthesis. Neuron 16:843-852.
31. Tipparaju SM, Barski OA, Srivastava S, Bhatnagar A (2008) Catalytic mechanism and substrate specificity of the beta-subunit of the voltage-gated potassium channel. Biochemistry 47:8840-8854.
32. + channels. J Biol Chem 282:24485-24489.
33. Washburn MS, Moises HC (1992) Muscarinic responses of rat basolateral amygdaloid neurons recorded in vitro. J Physiol 449:121-154.
34. Weng J, Cao Y, Moss N, Zhou M (2006) Modulation of voltage-dependent Shaker family potassium channels by an aldo-keto reductase. J Biol Chem 281:15194-15200.
35. Wu YQ, Heilstedt HA, Bedell JA, May KM, Starkey DE, McPherson JD, Shapira SK, Shaffer LG (1999) Molecular refinement of the 1p36 deletion syndrome reveals size diversity and a preponderance of maternally derived deletions. Hum Mol Genet 8:313-321.
36. Zhang W, Linden DJ (2003) The other side of the engram: experiencedriven changes in neuronal intrinsic excitability. Nat Rev Neurosci 4:885-900.