A case of chloroquine-induced cardiomyopathy that presented as sick sinus syndrome

Korean Circulation Journal

Volumn 40, Issue 11, 2010, Pages 604-608

  Lee, Jae Hak ^a   Chung, Woo Baek ^a   Kang, Ju Hyun ^a   Kim, Hyung Woo ^a   Kim, Jin Jin ^a   Kim, Ji Hyun ^a   Hwang, Hui Jeong ^a   Lee, Jea Beom ^a   Chung, Jong Won ^a   Kim, Hyo Lim ^b   Choi, Yun Seok ^a   Park, Chul Soo ^a   Youn, Ho Joong ^a   Lee, Man Young ^a  

^a The Catholic University of Korea   (South Korea)

^b The Catholic University of Korea College of Medicine   (South Korea)

Author keywords

Cardiomyopathy; Hydroxychloroquine; Restrictive; Sick sinus syndrome

Indexed keywords

CHLOROQUINE; HYDROXYCHLOROQUINE; PREDNISONE;

ADULT; ARTICLE; ARTIFICIAL HEART PACEMAKER; CARDIOMEGALY; CASE REPORT; CELL VACUOLE; CONNECTIVE TISSUE; DRUG WITHDRAWAL; ELECTRON MICROSCOPY; FEMALE; HEART LEFT VENTRICLE WALL; HEART MUSCLE BIOPSY; HEART MUSCLE CELL; HEART MUSCLE CONDUCTION SYSTEM; HEMODYNAMICS; HUMAN; MUSCLE HYPERTROPHY; NUCLEAR MAGNETIC RESONANCE IMAGING; PACEMAKER; RESTRICTIVE CARDIOMYOPATHY; RHEUMATOID ARTHRITIS; SEIZURE; SICK SINUS SYNDROME; THORAX PAIN;

EID: 78650879893     PISSN: 17385520     EISSN: 17385555     Source Type: Journal    
DOI: 10.4070/kcj.2010.40.11.604     Document Type: Article

References (20)

1. Cervera A, Espinosa G, Font J, Ingelmo M. Cardiac toxicity secondary to long term treatment with chloroquine. Ann Rheum Dis 2001; 60:301.
2. Iglesias Cubero G, Rodriguez Reguero JJ, Rojo Ortega JM. Restrictive cardiomyopathy caused by chloroquine. Br Heart J 1993;69:451-2.
3. Ratliff NB, Estes ML, Myles JL, Shirey EK, McMahon JT. Diagnosis of chloroquine cardiomyopathy by endomyocardial biopsy. N Engl J Med 1987;316:191-3.
4. Weiner A, Sandberg MA, Gaudio AR, Kini MM, Berson EL. Hydroxychloroquine retinopathy. Am J Ophthalmol 1991;112:528-34.
5. Hughes JT, Esiri M, Oxbury JM, Whitty CW. Chloroquine myopathy. Q J Med 1971;40:85-93.
6. Estes ML, Ewing-Wilson D, Chou SM, et al. Chloroquine neuromyotoxicit: clinical and pathologic perspective. Am J Med 1987;82:447-55.
7. Roos JM, Aubry MC, Edwards WD. Chloroquine cardiotoxicity: clinicopathologic features in three patients and comparison with three patients with Fabry disease. Cardiovasc Pathol 2002;11:277-83.
8. Keating RJ, Bhatia S, Amin S, Williams A, Sinak LJ, Edwards WD. Hydroxychloroquine-induced cardiotoxicity in a 39-year-old woman with systemic lupus erythematosus and systolic dysfunction. J Am Soc Echocardiogr 2005;18:981.
9. Rewcastle NB, Humphrey JG. Vacuolar myopathy: clinical, histochemical, and microscopic study. Arch Neurol 1965;12:570-82.
10. Whisnant JP, Espinosa RE, Kierland RR, Lambert EH. Chloroquine neuromyopathy. Proc Staff Meet Mayo Clin 1963;38:501-13.
11. Eadie MJ, Ferrier TM. Chloroquine myopathy. J Neurol Neurosurg Psychiatry 1966;29:331-7.
12. Mastaglia FL, Papadimitriou JM, Dawkins RL, Beveridge B. Vacuolar myopathy associated with chloroquine, lupus erythematosus and thymoma: report of a case with unusual mitochondrial changes and lipid accumulation in muscle. J Neurol Sci 1977;34:315-28.
13. Neville HE, Maunder-Sewry CA, McDougall J, Sewell JR, Dubowitz V. Chloroquine-induced cytosomes with curvilinear profiles in muscle. Muscle Nerve 1979;2:376-81.
14. Gerard JM, Stoupel N, Collier A, Flament-Durand J. Morphologic study of a neuromyopathy caused by prolonged chloroquine treatment. Eur Neurol 1973;9:363-79.
15. Fedorko ME, Hirsch JG, Cohn ZA. Autophagic vacuoles produced in vitro: II. studies on the mechanism of formation of autophagic vacuoles produced by chloroquine. J Cell Biol 1968;38:392-402.
16. Macdonald RD, Engel AG. Experimental chloroquine myopathy. J Neuropathol Exp Neurol 1970;29:479-99.
17. Motan J, Topinka I, Dura J, Kvapilova H. Chloroquine cardiodystrophy. Vnitr Lek 1978;24:1122-8.
18. Baguet JP, Tremel F, Fabre M. Chloroquine cardiomyopathy with conduction disorders. Heart 1999;81:221-3.
19. Chung KY, Nam KB, Ko KK, et al. A case of idiopathic restrictive cardiomyopathy. Korean Circ J 1990;20:260-4.
20. Bae EJ, Cheon EJ, Yun YS. Clinical profile and outcome of idiopathic restrictive cardiomyopathy in children. Korean Circ J 2001;31:427-33.