A practical, one-pot synthesis of sulfonylated pyridines

Organic Letters

Volumn 13, Issue 1, 2011, Pages 102-105

  Maloney, Kevin M ^a   Kuethe, Jeffrey T ^a   Linn, Kathleen ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PYRIDINE DERIVATIVE; SULFONE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; SYNTHESIS;

MOLECULAR STRUCTURE; PYRIDINES; SULFONES;

EID: 78650861142     PISSN: 15237060     EISSN: 15237052     Source Type: Journal    
DOI: 10.1021/ol102629c     Document Type: Article

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39. 2Tol was completely soluble in DMAc at 100 °C.
40. While protonation of sodium p -toluenesulfinate is a possibility in the presence of HCl, the fact that these reactions proceed to completion and in high yield suggest that protonation of the pyridine nitrogen is faster.
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45. Although not investigated in the present study, the methodology should be applicable to other types of alkyl and aryl sulfinate salts.