Postpartum toll-like receptors and β-defensin 5 mRNA levels in the endometrium of Holstein cows

Veterinary Immunology and Immunopathology

Volumn 139, Issue 2-4, 2011, Pages 277-281

  Martins, Telma da Mata ^a   Paixão, Tatiane Alves da ^a   Costa, Érica Azevedo ^a   Pires, Alexandre de Carvalho ^a   Santos, Renato Lima ^a   Borges, Álan Maia ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Defensin; Endometrial biopsy; Innate immunity; TLR; Uterine infection

Indexed keywords

BETA DEFENSIN 5; MESSENGER RNA; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6;

ANIMAL TISSUE; ARTICLE; BIRTH; COW; ENDOMETRIUM; INNATE IMMUNITY; METRITIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PLACENTA; PUERPERIUM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UTERUS BIOPSY;

ANIMALS; BETA-DEFENSINS; CATTLE; ENDOMETRIUM; FEMALE; GENE EXPRESSION REGULATION; POSTPARTUM PERIOD; PREGNANCY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TOLL-LIKE RECEPTORS;

EID: 78650855767     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetimm.2010.09.012     Document Type: Article

References (28)

1. Chapwanya A., Meade K.G., Doherty M.L., Callanan J.J., Mee J.F., O'Farrelly C. Histopathological and molecular evaluation of Holstein-Friesian cows postpartum: toward an improved understanding of uterine innate immunity. Theriogenology 2009, 71:1396-1407.
2. Davies D., Meade K.G., Herath S., Eckersall P.D., Gonzalez D., White J.O., Conlan R.S., O'Farrelly C., Sheldon I.M. Toll-like receptor and antimicrobial peptide expression in the bovine endometrium. Reprod. Biol. Endocrinol. 2008, 6:1-12.
3. Dohmen M.J.W., Joop K., Sturk A., Bols P.E.J., Lohuis J.A.C.M. Relationship between intra-uterine bacterial contamination, endotoxin levels and the development of endometritis in postpartum cows with dystocia or retained placenta. Theriogenology 2000, 54:1019-1032.
4. Edmonson A.J., Lean I.J., Weaver L.D., Farver T., Webster G. A body condition scoring chart for Holstein dairy cows. J. Dairy Sci. 1989, 72:68-78.
5. Fazeli A., Bruce C., Anumba D.O. Characterization of Toll-like receptors in the female reproductive tract in humans. Hum. Reprod. 2005, 20:1372-1378.
6. Ganz T. The role of antimicrobial peptides in innate immunity. Integr. Comp. Biol. 2003, 43:300-304.
7. Goldammer T., Zerbe H., Molenaar A., Schuberth H.J., Brunner R.M., Kata S.R., Seyfert H.M. Mastitis increases mammary mRNA abundance of β-defensin 5, toll-like-receptor 2 (TLR2), and TLR 4 but not TLR9 in cattle. Clin. Diagn. Lab. Immunol. 2004, 11:174-185.
8. Herath S., Fischer D.P., Werling D., Williams E.J., Lilly S.T., Dobson H., Bryant C.E., Sheldon I.M. Expression and function of Toll-like receptor 4 in the endometrial cells of the uterus. Endocrinology 2006, 147:562-570.
9. Herath S., Lilly S.T., Santos N.R., Gilbert R.O., Goetze L., Bryant C.E., White J.O., Cronin J., Sheldon I.M. Expression of genes associated with immunity in the endometrium of cattle with disparate postpartum uterine disease and fertility. Reprod. Biol. Endocrinol. 2009, 55:1-13.
10. Horne A.W., Stock S.J., King A.E. Innate immunity and disorders of the female reproductive tract. Reproduction 2008, 135:739-749.
11. Ibeagha-Awemu E.M., Lee J.W., Ibeagha A.E., Bannerman D.D., Paape M.J., Zhao X. Bacterial lipopolysaccharide induces increased expression of toll-like receptor (TLR) 4 and downstream TLR signaling molecules in bovine mammary epithelial cells. Vet. Res. 2008, 39:11.
12. Ishii K.J., Koyama A., Coban C., Akira S. Host innate immune receptors and beyond: making sense of microbial infections. Cell. Host Microbe 2008, 3:352-363.
13. King A.E., Critchle Y.H.O.D., Kelly R.W. Innate immune defences in the human endometrium. Reprod. Biol Endocrinol. 2003, 1:1-8.
14. Lehrer R.L., Lichtestein A.K., Ganz T. Defensins: antimicrobial and cytotoxic peptides of mammalian cells. Annu. Rev. lmmunol. 1993, 11:105-128.
15. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCt method. Methods 2001, 25:402-408.
16. McGuire K., Jones M., Werling D., Williams J.L., Glass E.J., Jann O. Radiation hybrid mapping of all 10 characterized bovine Toll-like receptors. Anim. Gen. 2005, 37:47-50.
17. Medzhitov R., Janeway .C.A. Innate immunity: impact on the adaptive imune response. Curr. Opin. Immunol. 1997, 9:4-9.
18. Pioli P.A., Amiel E., Schaefer T.M., Connolly J.E., Wira C.R., Guyre1 P.M. Differential expression of toll-Like receptors 2 and 4 in tissues of the human female reproductive tract. Infect. Immun. 2004, 72:5799-5806.
19. Rozen S., Skaletsky H. Primer3 on the www for general users and for biologist programmers. Methods Mol. Biol. 2000, 132:365-386.
20. Schaefer T.M., Souza K., Fahey J.V., Beagley K.W., Wira C.R. Toll-like receptor (TLR) expression and TLR-mediated cytokine/chemokine production by human uterine epithelial cells. Immunology 2004, 112:428-436.
21. Sheldon I.M., Lewis G.S., LeBlanc S.J., Gilbert R.O. Defining postpartum uterine disease in cattle. Theriogenology 2006, 65:1516-1530.
22. Sheldon I.M., Cronin J., Goetze L., Donofrio G., Schuberth H.J. Defining postpartum uterine disease and the mechanisms of infection and immunity in the female reproductive tract in cattle. Biol. Reprod. 2009, 81:1025-1032.
23. Soboll G., Schaefer T.M., Wira C.R. Effect of toll-like receptor (TLR) agonists on TLR and microbicide expression in uterine and vaginal tissues of the mouse. Am. J. Reprod. Immunol. 2006, 55:434-446.
24. Soboll G., Shen L., Wira C.R. Expression of toll-like receptors (TLR) and responsivenes to TLR agonists by polarized mouse uterine epithelial cells in culture. Biol. Reprod. 2006, 75:131-139.
25. Werling D., Coffey T.J. Pattern recognition receptors in companion and farm animals-the key to unlocking the door to animal disease?. Vet. J. 2007, 174:240-251.
26. Werling D., Jungi T.W. Toll-like receptors linking innate and adaptative immune response. Vet. Immunol. Immunopathol. 2003, 91:1-12.
27. Willians E.L., Fisher D.P., Pfeiffer D.U., Englanda G.C.W., Noakes D.E., Dobson H., Sheldon I.M. Clinical evaluation of postpartum vaginal mucus reflects uterine bacterial infection and the immune response in cattle. Theriogenology 2005, 63:102-117.
28. Young S.L., Lydon T.D., Jorgenson R.L., Misfeldt M.L. Expression of toll-like receptors in human epithelial cells and cell lines. Am. J. Rep. Immunol. 2004, 52:67-73.