The botulinum toxin complex meets E-cadherin on the way to its destination

Cell Adhesion and Migration

Volumn 5, Issue 1, 2011, Pages 34-36

  Sugawara, Yo ^a   Fujinaga, Yukako ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

Botulinum toxin; Clostridium botulinum; E cadherin; Epithelial barrier; Food borne botulism; Hemagglutinin; Tight junction

Indexed keywords

BOTULINUM TOXIN; HEMAGGLUTININ; PROTEINASE; UVOMORULIN;

BOTULISM; DIGESTIVE SYSTEM; EPITHELIUM; HUMAN; INTESTINE EPITHELIUM; NOTE; PH; PROTEIN BINDING; PROTEIN INTERACTION;

ANIMALIA; CLOSTRIDIUM BOTULINUM;

EID: 78650828434     PISSN: 19336918     EISSN: 19336926     Source Type: Journal    
DOI: 10.4161/cam.5.1.13574     Document Type: Note

References (35)

1. Arnon SS, Schechter R, Inglesby TV, Henderson DA, Bartlett JG, Ascher MS, et al. Botulinum toxin as a biological weapon: medical and public health management. JAMA 2001; 285:1059-70.
2. Schiavo G, Matteoli M, Montecucco C. Neurotoxins affecting neuroexocytosis. Physiol Rev 2000; 80:717-66.
3. Sakaguchi G. Clostridium botulinum toxins. Pharmacol Ther 1982; 19:165-94.
4. Oguma K, Inoue K, Fujinaga Y, Yokota K, Watanabe T, Ohyama T, et al. Structure and function of Clostridium botulinum progenitor toxin. J Toxicol-Toxin Rev 1999; 18:17-34.
5. Ohishi I, Sugii S, Sakaguchi G. Oral toxicities of Clostridium botulinum toxins in response to molecular size. Infect Immun 1977; 16:107-9.
6. Sugii S, Ohishi I, Sakaguchi G. Correlation between oral toxicity and in vitro stability of Clostridium botulinum type A and B toxins of different molecular sizes. Infect Immun 1977; 16:910-4.
7. Lamanna C. Hemagglutination by botulinal toxin. Proc Soc Exp Biol Med 1948; 69:332-6.
8. Fujinaga Y, Inoue K, Watanabe S, Yokota K, Hirai Y, Nagamachi E, et al. The hemagglutinin of Clostridium botulinum type C progenitor toxin plays an essential role in binding of toxin to the epithelial cells of guinea pig small intestine, leading to the efficient absorption of the toxin. Microbiology 1997; 143:3841-7.
9. Fujinaga Y, Inoue K, Nomura T, Sasaki J, Marvaud JC, Popoff MR, et al. Identification and characterization of functional subunits of Clostridium botulinum type A progenitor toxin involved in binding to intestinal microvilli and erythrocytes. FEBS Lett 2000; 467:179-83.
10. Niwa K, Koyama K, Inoue S, Suzuki T, Hasegawa K, Watanabe T, et al. Role of nontoxic components of serotype D botulinum toxin complex in permeation through a Caco-2 cell monolayer, a model for intestinal epithelium. FEMS Immunol Med Microbiol 2007; 49:346-52. (Pubitemid 46435011)
11. Arimitsu H, Sakaguchi Y, Lee JC, Ochi S, Tsukamoto K, Yamamoto Y, et al. Molecular properties of each subcomponent in Clostridium botulinum type B haemagglutinin complex. Microb Pathog 2008; 45:142-9.
12. Nishikawa A, Uotsu N, Arimitsu H, Lee JC, Miura Y, Fujinaga Y, et al. The receptor and transporter for internalization of Clostridium botulinum type C progenitor toxin into HT-29 cells. Biochem Biophys Res Commun 2004; 319:327-33.
13. Uotsu N, Nishikawa A, Watanabe T, Ohyama T, Tonozuka T, Sakano Y, et al. Cell internalization and traffic pathway of Clostridium botulinum type C neurotoxin in HT-29 cells. Biochim Biophys Acta 2006; 1763:120-8.
14. Maksymowych AB, Simpson LL. Binding and transcytosis of botulium neurotoxin by polarized human colon carcinoma cells. J Biol Chem 1998; 273:21950-7.
15. Couesnon A, Pereira Y, Popoff MR. Receptor-mediated transcytosis of botulinum neurotoxin A through intestinal cell monolayers. Cell Microbiol 2008; 10:375-87.
16. Matsumura T, Jin Y, Kabumoto Y, Takegahara Y, Oguma K, Lencer WI, et al. The HA proteins of botulinum toxin disrupt intestinal epithelial intercellular junctions to increase toxin absorption. Cell Microbiol 2008; 10:355-64.
17. Jin Y, Takegahara Y, Sugawara Y, Matsumura T, Fujinaga Y. Disruption of the epithelial barrier by botulinum haemagglutinin (HA) proteins - differences in cell tropism and the mechanism of action between HA proteins of types A or B, and HA proteins of type C. Microbiology 2009; 155:35-45.
18. Sugawara Y, Matsumura T, Takegahara Y, Jin Y, Tsukasaki Y, Takeichi M, et al. Botulinum hemagglutinin disrupts the intercellular epithelial barrier by directly binding E-cadherin. J Cell Biol 2010; 189:691-700.
19. Takeichi M. The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. Development 1988; 102:639-55.
20. Citi S. The molecular organization of tight junctions. J Cell Biol 1993; 121:485-9.
21. Mengaud J, Ohayon H, Gounon P, Mège RM, Cossart P. E-cadherin is the receptor for internalin, a surface protein required for entry of L. monocytonenes into epithelial cells. Cell 1996; 84:923-32.
22. Lecuit M, Vandormael-Pournin S, Lefort J, Huerre M, Gounon P, Dupuy C, et al. A transgenic model for listeriosis: role of internalin in crossing the intestinal barrier. Science 2001; 292:1722-5.
23. Phan QT, Myers CL, Fu Y, Sheppard DC, Yeaman MR, Welch WH, et al. Als3 is a Candida albicans invasin that binds to cadherins and induces endocytosis by host cells. PLoS Biol 2007; 5:e64.
24. Obiso RJ Jr, Azghani AO, Wilkins TD. The Bacteroides fragilis toxin fragilysin disrupts the paracellular barrier of epithelial cells. Infect Immun 1997; 65:1431-9.
25. Wu S, Lim KC, Huang J, Saidi RF, Sears CL. Bacteroides fragilis enterotoxin cleaves the zonula adherens protein, E-cadherin. Proc Natl Acad Sci USA 1998; 95:14979-84.
26. Katz J, Sambandam V, Wu JH, Michalek SM, Balkovetz DF. Characterization of Porphyromonas gingivalis-induced degradation of epithelial cell junctional complexes. Infect Immun 2000; 68:1441-9.
27. Katz J, Yang QB, Zhang P, Potempa J, Travis J, Michalek SM, et al. Hydrolysis of epithelial junctional proteins by Porphyromonas gingivalis gingipains. Infect Immun 2002; 70:2512-8.
28. Frank CF, Hostetter MK. Cleavage of E-cadherin: a mechanism for disruption of the intestinal epithelial barrier by Candida albicans. Transl Res 2007; 149:211-22.
29. Villar CC, Kashleva H, Nobile CJ, Mitchell AP, Dongari-Bagtzoglou A. Mucosal tissue invasion by Candida albicans is associated with E-cadherin degradation, mediated by transcription factor Rim101p and protease Sap5p. Infect Immun 2007; 75:2126-35.
30. Boggon TJ, Murray J, Chappuis-Flament S, Wong E, Gumbiner BM, Shapiro L. C-cadherin ectodomain structure and implications for cell adhesion mechanisms. Science 2002; 296:1308-13.
31. Gumbiner B, Stevenson B, Grimaldi A. The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex. J Cell Biol 1988; 107:1575-87.
32. Watabe M, Nagafuchi A, Tsukita S, Takeichi M. Induction of polarized cell-cell association and retardation of growth by activation of the E-cadherincatenin adhesion system in a dispersed carcinoma line. J Cell Biol 1994; 127:247-56.
33. Hasegawa K, Watanabe T, Suzuki T, Yamano A, Oikawa T, Sato Y, et al. A novel subunit structure of Clostridium botulinum serotype D toxin complex with three extended arms. J Biol Chem 2007; 282:24777-83.
34. Gross WB, Smith LDS. Experimental botulism in gallinaceous birds. Avian Dis 1971; 15:716-22.
35. Notermans S, Dufrenne J, Kozaki S. Experimental botulism in Pekin ducks. Avian Dis 1980; 24:658-64.