Effect of 4% topical lidocaine applied to the face on the serum levels of lidocaine and its metabolite, monoethylglycinexylidide

Aesthetic Surgery Journal

Volumn 30, Issue 6, 2010, Pages 853-858

  Oni, Georgette ^a   Brown, Spencer ^a   Burrus, Clint ^a   Grant, Lorin ^a   Watkins, Jeff ^a   Kenkel, Matthew ^a   Barton Jr , Fritz ^a   Kenkel, Jeffrey ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

lidocaine; lidocaine toxicity; monoethyglycinexylidide; topical anesthetics

Indexed keywords

DEETHYLLIDOCAINE; LIDOCAINE;

ADULT; ARTICLE; BLOOD LEVEL; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FACE; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; OCCLUSION; OCCLUSIVE DRESSING; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE;

ADMINISTRATION, TOPICAL; ADULT; ANESTHETICS, LOCAL; FACE; FEMALE; HUMANS; LIDOCAINE; MALE; MIDDLE AGED;

EID: 78650825695     PISSN: 1090820X     EISSN: 1527330X     Source Type: Journal    
DOI: 10.1177/1090820X10386944     Document Type: Article

References (26)

1. Marra DE, Yip D., Fincher EF, Moy RL Systemic toxicity from topically applied lidocaine in conjunction with fractional photothermolysis. Arch Dermatol 2006 ; 142: 1024-1026.
2. Hahn IH, Hoffman RS, Nelson LS EMLA-induced methemoglobinemia and systemic topical anesthetic toxicity. J Emerg Med 2004 ; 26: 85-88.
3. Rao RB, Ely SF, Hoffman RS Deaths related to liposuction. N Engl J Med 1999 ; 340: 1471-1475.
4. Kaweski S. Topical anesthetic creams. Plast Reconstr Surg 2008 ; 121: 2161-2165.
5. Bursell B., Ratzan RM, Smally AJ Lidocaine toxicity misinterpreted as a stroke. West J Emerg Med 2009 ; 10: 292-294.
6. Curtis LA, Dolan TS, Seibert HE Are one or two dangerous? Lidocaine and topical anesthetic exposures in children. J Emerg Med 2009 ; 37: 32-39.
7. Brosh-Nissimov T., Ingbir M., Weintal I., Fried M., Porat R. Central nervous system toxicity following topical skin application of lidocaine. Eur J Clin Pharmacol 2004 ; 60: 683-684.
8. Martinez MA, Ballesteros S., Segura LJ, García M. Reporting a fatality during tumescent liposuction. Forensic Sci Int 2008 ; 178: e11-16.
9. Kenkel JM, Lipschitz AH, Shepherd G., et al. Pharmacokinetics and safety of lidocaine and monoethylglycinexylidide in liposuction: a microdialysis study. Plast Reconstr Surg 2004 ; 114: 516-524; discussion 525-516.
10. Kato N., Fujiwara Y., Harato M., et al. Serum concentration of lidocaine after transversus abdominis plane block. J Anesth 2009 ; 23: 298-300.
11. Rygnestad T., Samdal F. Plasma concentrations of monoethylglycinexylidide during and after breast augmentation. Plast Reconstr Surg 2000 ; 106: 728-731.
12. Rygnestad T., Brevik BK, Samdal F. Plasma concentrations of lidocaine and alpha1-acid glycoprotein during and after breast augmentation. Plast Reconstr Surg 1999 ; 103: 1267-1272.
13. Leopold A., Wilson S., Weaver JS, Moursi AM Pharmacokinetics of lidocaine delivered from a transmucosal patch in children. Anesth Prog 2002 ; 49: 82-87.
14. Burk RW, 3rd, Guzman-Stein G., Vasconez LO Lidocaine and epinephrine levels in tumescent technique liposuction. Plast Reconstr Surg 1996 ; 97: 1379-1384.
15. Klotz U. Antiarrhythmics: elimination and dosage considerations in hepatic impairment. Clin Pharmacokinet 2007 ; 46: 985-996.
16. Rosenberg PH, Veering BT, Urmey WF Maximum recommended doses of local anesthetics: a multifactorial concept. Reg Anesth Pain Med 2004 ; 29: 564-575 ; discussion 524.
17. De Martin S., Orlando R., Bertoli M., Pegoraro P., Palatini P. Differential effect of chronic renal failure on the pharmacokinetics of lidocaine in patients receiving and not receiving hemodialysis. Clin Pharmacol Ther 2006 ; 80: 597-606.
18. Isohanni MH, Ahonen J., Neuvonen PJ, Olkkola KT Effect of ciprofloxin on the pharmacokinetics of intravenous lidocaine. Eur J Anaesthesiol 2005 ; 22: 795-799.
19. Orlando R., Piccoli P., De Martin S., et al. Cytochrome P450 1A2 is a major determinant of lidocaine metabolism in vivo: effects of liver function. Clin Pharmacol Ther 2004 ; 75: 80-88.
20. Grazer FM, Meister FL Complications of the tumescent formula for liposuction. Plast Reconstr Surg 1997 ; 100: 1893-1896.
21. Rolsted K., Benfeldt E., Kissmeyer AM, Rist GM, Hansen SH Cutaneous in vivo metabolism of topical lidocaine formulation in human skin. Skin Pharmacol Physiol 2009 ; 22: 124-127.
22. Estes NA, 3rd, Manolis AS, Greenblatt DJ, Garan H., Ruskin JN Therapeutic serum lidocaine and metabolite concentrations in patients undergoing electrophysiologic study after discontinuation of intravenous lidocaine infusion. Am Heart J 1989 ; 117: 1060-1064.
23. Ogden L., Love G., Basta S. Systemic exposure to lidocaine and tetracaine is low after an application of a lidocaine 7%-tetracaine 7% peel in adults. Int J Dermatol 2008 ; 47: 87-90.
24. Rincon E., Baker RL, Iglesias AJ, Duarte M. CNS toxicity after topical application of EMLA cream on a toddler with molluscum contagiosum. Pediatr Emerg Care 2000 ; 16: 252-254.
25. Goodwin DP, McMeekin TO A case of lidocaine absorption from topical administration of 40% lidocaine cream. J Am Acad Dermatol 1999 ; 41: 280-281.
26. Nestor MS Safety of occluded 4% liposomal lidocaine cream. J Drugs Dermatol 2006 ; 5: 618-620.