Central nervous system toxicity following topical skin application of lidocaine

European Journal of Clinical Pharmacology

Volumn 60, Issue 9, 2004, Pages 683-684

  Brosh Nissimov, Tal ^a   Ingbir, Merav ^a   Weintal, Iris ^a   Fried, Mordechai ^a   Porat, Reuven ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

Adverse effects; CNS; EMLA; Lidocaine; Prilocaine; Toxicity

Indexed keywords

ANESTHETIC AGENT; EMLA; LIDOCAINE;

ADULT; BLOOD ANALYSIS; CASE REPORT; CEREBROSPINAL FLUID ANALYSIS; COMPUTER ASSISTED TOMOGRAPHY; CONFUSION; DISORIENTATION; ELECTROCARDIOGRAPHY; ESTHETIC SURGERY; FOLLICULITIS; HEADACHE; HUMAN; LABORATORY TEST; LETTER; LUMBAR PUNCTURE; MALE; MEDICAL EXAMINATION; MUSCLE WEAKNESS; NAUSEA; NEUROTOXICITY; PRIORITY JOURNAL; TOPICAL TREATMENT; UNCONSCIOUSNESS; VOMITING;

ADMINISTRATION, TOPICAL; ADULT; ANESTHETICS, LOCAL; CENTRAL NERVOUS SYSTEM DISEASES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LIDOCAINE; MALE; OINTMENTS; PRILOCAINE;

EID: 11244269487     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-004-0814-4     Document Type: Letter

References (21)

1. Shand DG (1984) Alpha 1-acid glycoprotein and plasma lidocaine binding. Clin Pharmacokinet 9:27-31
2. Wojcicki J, Kozlowsky K, Drozdzik M, Wojcicki M (2002) Lidocaine elimination in patients with liver cirrhosis. Acta Pol Pharm 59(4):321-324
3. Testa R, Campo N, Caglieris S, Risso D, Alvarez S, Arzani L et al (1998) Lidocaine elimination and monoethylglycinexylidide formation in patients with chronic hepatitis or cirrhosis. Hepatogastroenterology 45(19):154-159
4. McKindley DS, Boulet J, Sachdeva K, Wang P, Chichester C (2002) Endotoxic shock alters the pharmacokinetics of lidocaine and monoethylglycinexylidide. Shock 17(3):199-204
5. Collinsworth KA, Strong JM, Atkinson AJ Jr, Winkle RA, Perlroth F, Harrison DC (1975) Pharmacokinetics and metabolism of lidocaine in patients with renal failure. Clin Pharmacol Ther 18(1):59-64
6. Lili C, Shibata N, Yoshikawa Y, Takada K (2003) Effect of glycerol-induced acute renal failure on the pharmacokinetics of lidocaine after transdermal application in rats. Biol Pharm Bull 26(8):1150-1154
7. du Souich P, Saunier C, Hartemann D, Allam M (1992) Effect of acute and chronic moderate hypoxia on the kinetics of lidocaine and its metabolites and on regional blood flow. Pulm Pharmacol Ther 5(1):9-16
8. Pardridge WM, Sakiyama R, Fierer G (1984) Blood-brain barrier transport and brain sequestration of propranolol and lidocaine. Am J Physiol 247(3):R582-588
9. Laurikainen E, Marttila R, Lindberg R, Kanto J (1983) Penetration of lidocaine and its active desethylated metabolite into cerebrospinal fluid in man. Eur J Clin Pharmacol 25(5):639-641
10. Tsai PS, Buerkle H, Huang LT, Lee TC, Yang LC, Lee JH (1998) Lidocaine concentrations in plasma and cerebrospinal fluid after systemic bolus administration in humans. Anesth Analg 87(3):601-604
11. Parfitt K (ed) (1999) Martindale, the complete drug reference, 32nd edn. Pharmaceutical Press, London
12. Elad S, Cohen G, Zylber-Katz E, Findler M, Galili D, Garfunkel AA et al (1999) Systemic absorption of lidocaine after topical application for the treatment of oral mucositis in bone marrow transplantation patients. J Oral Pathol Med 28(4):170-172
13. Wu FL, Razzaghi A, Souney PF (1993) Seizure after lidocaine for bronchoscopy: case report and review of the use of lidocaine in airway anaesthesia. Pharmacotherapy 13(1):72-78
14. Denaro CP, Benowitz NL (1989) Poisoning due to class 1B antiarrhythmic drugs. Lignocaine, mexiletine and tocainide. Med Toxicol Adverse Exp 4(6):412-428
15. Zdziarsky P (2001) Hoigne syndrome as an acute non-allergic reaction to different drugs: case reports. Pol Merkuriusz Lek 10(60):453-455
16. Ameer B, Burlingame MB, Harman EM (1989) Systemic absorption of lidocaine in elderly and young adults undergoing bronchoscopy. Pharmacotherapy 9(2):74-81
17. Smith M, Wolfram W, Rose R (1992) Toxicity - seizures in an infant caused by (or related to) oral viscous lidocaine use. J Emerg Med 10(5):587-590
18. Mofenson HC, Caraccio TR, Miller H, Greensher J (1983) Lidocaine toxicity from topical mucosal application. With a review of the clinical pharmacology of Lidocaine. Clin Pediatr 22(3):190-192
19. Mehra P, Caiazzo A, Maloney P (1998) Lidocaine toxicity. Anesth Prog 45(1):38-41
20. Sharma SC, Rama PR, Miller GL, Coccio EB, Coulter LJ (1996) Systemic absorption and toxicity from topically administered lidocaine during transesophageal echocardiography. J Am Soc Echocardiogr 9(5):710-711
21. Rincon E, Baker RL, Iglesias AJ, Duarte AM (2000) CNS toxicity after topical application of EMLA cream on a toddler with molluscum contagiosum. Pediatr Emerg Care 16(4):252-254