Antinociceptive effect of spirocyclopiperazinium salt compound LXM-15 via activating peripheral α7 nAChR and M4 mAChR in mice

Neuropharmacology

Volumn 60, Issue 2-3, 2011, Pages 446-452

  Zhao, Xia ^b   Ye, Jia ^a,b   Sun, Qi ^b   Xiong, Yulan ^b   Li, Runtao ^b   Jiang, Yimin ^a  

^a PEKING UNIVERSITY   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

7 nicotinic acetylcholine receptor; Antinociception; LXM 15; M4 muscarine acetylcholine receptor

Indexed keywords

8 (NITROPHENYL) 5,8 DIAZASPIRO[4.5]DECANE BROMIDE; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ANTINOCICEPTIVE AGENT; ASPARTATE AMINOTRANSFERASE; ATROPINE; ATROPINE METHYL NITRATE; FORMALDEHYDE; HEXAMETHONIUM; LIVER ENZYME; LXM 15; MECAMYLAMINE; METHYLLYCACONITINE; MORPHINE; MUSCARINIC M4 RECEPTOR; NALOXONE; NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA7; NICOTINIC RECEPTOR; SPIROCYCLOPIPERAZINIUM DERIVATIVE; TROPICAMIDE; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; BITE; BODY TEMPERATURE; CHOLINERGIC STIMULATION; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG RECEPTOR BINDING; ENZYME ACTIVITY; HEART RATE; HOT PLATE TEST; LETHAL DOSE; LICKING; LOCOMOTION; MALE; MOTOR COORDINATION; MOUSE; NONHUMAN; PHYSICAL ACTIVITY; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; WRITHING TEST;

ANALGESICS; ANIMALS; FEMALE; MALE; MICE; MICE, INBRED C57BL; PAIN MEASUREMENT; PIPERAZINES; PROTEIN BINDING; RATS; RATS, WISTAR; RECEPTOR, MUSCARINIC M4; RECEPTORS, NICOTINIC; SPIRO COMPOUNDS;

EID: 78650822555     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2010.10.019     Document Type: Article

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