Divergent roles of NF-κB and Egr-1 in flow-dependent restenosis after angioplasty and stenting

Atherosclerosis

Volumn 214, Issue 1, 2011, Pages 65-72

  Murrell, Melanie ^a   Khachigian, Levon M ^b   Ward, Michael R ^a  

^a ROYAL NORTH SHORE HOSPITAL   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Decoy oligo nucleotide; Egr 1; Flow; NF B; Restenosis; Stent

Indexed keywords

EARLY GROWTH RESPONSE FACTOR 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OLIGODEOXYNUCLEOTIDE; PYRROLIDINE DITHIOCARBAMATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY INTIMA PROLIFERATION; ARTICLE; CAROTID ANGIOPLASTY; CAROTID ARTERY FLOW; CAROTID ARTERY STENTING; CONTROLLED STUDY; DRUG EFFECT; GENE ACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; RESTENOSIS;

ANGIOPLASTY; ANIMALS; ANTIOXIDANTS; CAROTID ARTERIES; CORONARY RESTENOSIS; EARLY GROWTH RESPONSE PROTEIN 1; LIPOSOMES; NF-KAPPA B; OLIGODEOXYRIBONUCLEOTIDES; OLIGONUCLEOTIDES; OXIDATION-REDUCTION; PYRROLIDINES; RABBITS; STENTS; THIOCARBAMATES; TRANSCRIPTION FACTORS;

EID: 78650816060     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2010.10.003     Document Type: Article

References (18)

1. Beyar R. Novel approaches to reduce restenosis. Ann N Y Acad Sci 2004, 1015:367-378.
2. Wentzel J.J., Gijsen F.J., Stergiopulos N., Serruys P.W., Slager C.J., Krams R. Shear stress, vascular remodeling and neointimal formation. J Biomech 2003, 36:681-688.
3. Ward M.R, Tsao P.S., Agrotis A., Dilley R.J., Jennings G.L., Bobik A. Low blood flow after angioplasty augments mechanisms of restenosis: inward vessel remodeling, cell migration, and activity of genes regulating migration. Arterioscler Thromb Vasc Biol 2001, 21:208-213.
4. Ward M.R., Tsao P.S., Herity N.A., Cooke J.P., Yeung A.C. Flow-responsive remodeling after angioplasty is enhanced by high cholesterol diet. Prevention with pyrrolidine dithiocarbamate. Atherosclerosis 2003, 168:333-341.
5. Hanratty C.G., Murrell M., Khachigian L.M., Tsao P.S., Ward M.R. Low flow promotes instent intimal hyperplasia. Comparison with lumen loss in balloon-injured and uninjured vessels and the effects of the antioxidant pyrrolidine dithiocarbamate. Atherosclerosis 2004, 177:269-274.
6. Murrell M., Khachigian L., Ward M.R. The role of c-jun in PDTC-sensitive flow-dependent restenosis after angioplasty and stenting. Atherosclerosis 2007, 194:364-371.
7. Cercek B., Yamashita M., Dimayuga P., et al. Nuclear factor-kappaB activity and arterial response to balloon injury. Atherosclerosis 1997, 131:59-66.
8. Khachigian L.M. Early growth response-1 in cardiovascular pathobiology. Circ Res 2006, 98:186-191.
9. Resnick N., Yahav H., Khachigian L.M., et al. Endothelial gene regulation by laminar shear stress. Adv Exp Med Biol 1997, 430:155-164.
10. Wang C.C., Sharma G., Draznin B. Early growth response gene-1 expression in vascular smooth muscle cells effects of insulin and oxidant stress. Am J Hypertens 2006, 19:366-372.
11. Aoki M., Nata T., Morishita R., et al. Endothelial apoptosis induced by oxidative stress through activation of NF-kappaB: antiapoptotic effect of antioxidant agents on endothelial cells. Hypertension 2001, 38:48-55.
12. Santiago F.S., Lowe H.C., Kavurma M.M., et al. New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury. Nat Med 1999, 5:1438.
13. Ohtani K., Egashira K., Usui M., et al. Inhibition of neointimal hyperplasia after balloon injury by cis-element 'decoy' of early growth response gene-1 in hypercholesterolemic rabbits. Gene Ther 2004, 11:126-134.
14. Autieri M.V., Yue T.L., Ferstein G.Z., Ohlstein E. Antisense oligonucleotides to the p65 subunit of NF-κB inhibit human vascular smooth muscle cell adherence and proliferation and prevent neointima formation in rat carotid arteries. Biochem Biophys Res Commun 1995, 213:827-836.
15. Yamasaki K., Asai T., Shimizu M., et al. Inhibition of NFkappaB activation using cis-element 'decoy' of NFkappaB binding site reduces neointimal formation in porcine balloon-injured coronary artery model. Gene Ther 2003, 10:356-364.
16. Yoshimura S., Morishita R., Hayashi K., et al. Inhibition of intimal hyperplasia after balloon injury in rat carotid artery model using cis-element 'decoy' of nuclear factor-kappaB binding site as a novel molecular strategy. Gene Ther 2001, 8:1635-1642.
17. Kalinowski M., Viehofer K., Hamann C., et al. Local administration of NF-kappa B decoy oligonucleotides to prevent restenosis after balloon angioplasty: an experimental study in New Zealand white rabbits. Cardiovasc Intervent Radiol 2005, 28:331-337.
18. Breuss J.M., Cejna M., Bergmeister H., et al. Activation of nuclear factor-kappa B significantly contributes to lumen loss in a rabbit iliac artery balloon angioplasty model. Circulation 2002, 105:633-638.