메뉴 건너뛰기




Volumn 31, Issue SUPPL. 1, 2011, Pages 62-67

Future hepatitis C virus treatment: Interferon-sparing combinations

Author keywords

Direct acting antiviral (DAA); Hepatitis C; Pegylated interferon; Polymerase inhibitor; Protease inhibitor; Standard of care (SOC)

Indexed keywords

ABT 072; ABT 333; ABT 450; ACH 1625; ALISPORIVIR; ANA 598; AZD 7295; BI 201335; BI 207127; BMS 650032; BMS 790052; BMS 791325; BMS 824393; BOCEPREVIR; CYCLOSPORIN A [4 N METHYLISOLEUCINE]; DANOPREVIR; GS 9190; GS 9256; IDX 184; IDX 320; IDX 375; INTERFERON; MK 0608; MK 3281; N [[[6 (2 CARBOXY 2,3 DIHYDRO 1H ISOINDOL 4 YL) 2,2 DIMETHYLHEXYL]OXY]CARBONYL] 3 METHYLVALYL 4 HYDROXYPROLYL 1 AMINO N (CYCLOPROPYLSULFONYL) 2 ETHYLCYCLOPROPANECARBOXAMIDE LACTONE; NARLAPREVIR; PEGINTERFERON; PPI 1301; PPI 461; PROTEINASE INHIBITOR; PSI 7977; RG 7128; RG 7348; RIBAVIRIN; TELAPREVIR; TMC 435350; UNCLASSIFIED DRUG; UNINDEXED DRUG; VX 222; VX 759; VX 985;

EID: 78650806908     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2010.02383.x     Document Type: Article
Times cited : (35)

References (32)
  • 1
    • 59149085501 scopus 로고    scopus 로고
    • The global burden of hepatitis C
    • Lavanchy D. The global burden of hepatitis C. Liver Int 2009; 29 (Suppl. 1): 74-81.
    • (2009) Liver Int , vol.29 , Issue.SUPPL. 1 , pp. 74-81
    • Lavanchy, D.1
  • 2
    • 78650829561 scopus 로고    scopus 로고
    • CDC Compressed Mortality File. Available at, accessed 1 June 2008).
    • CDC Compressed Mortality File. Available at (accessed 1 June 2008).
  • 3
    • 78650840370 scopus 로고    scopus 로고
    • National Health and Nutrition Examination Surveys 1988-2006. Available at, accessed 1 June 2008).
    • National Health and Nutrition Examination Surveys 1988-2006. Available at (accessed 1 June 2008).
  • 4
    • 33646852746 scopus 로고    scopus 로고
    • Prevalence of HCV infection in the United States
    • Armstrong G, Wasley A, Simard E, et al. Prevalence of HCV infection in the United States. Ann Int Med 2006; 144: 705-14.
    • (2006) Ann Int Med , vol.144 , pp. 705-14
    • Armstrong, G.1    Wasley, A.2    Simard, E.3
  • 5
    • 42249111023 scopus 로고    scopus 로고
    • Changing trends in HCV-related mortality in USA
    • Wise M, Bialek S, Bell B, et al. Changing trends in HCV-related mortality in USA. Hepatology 2008; 47: 1128-35.
    • (2008) Hepatology , vol.47 , pp. 1128-35
    • Wise, M.1    Bialek, S.2    Bell, B.3
  • 6
    • 7044264264 scopus 로고    scopus 로고
    • HCV and increasing incidence of hepatocellular carcinoma
    • Gastroenterology
    • Davila J, Morgan R, Shaib Y, et al. HCV and increasing incidence of hepatocellular carcinoma: a population-based study. Gastroenterology 2004; 127: 1372-80.
    • (2004) a population-based study , vol.127 , pp. 1372-80
    • Davila, J.1    Morgan, R.2    Shaib, Y.3
  • 7
    • 78650816798 scopus 로고    scopus 로고
    • Projecting future complications of chronic hepatitis C in United States
    • Davis G, Albright J, Cook S. Projecting future complications of chronic hepatitis C in United States. Gastroenterology 2010; 139: 331-8.
    • (2010) Gastroenterology , vol.139 , pp. 331-8
    • Davis, G.1    Albright, J.2    Cook, S.3
  • 8
    • 0035934568 scopus 로고    scopus 로고
    • Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C
    • Lancet
    • Manns MP, McHutchison JG, Gordon SC, et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 2001; 358: 958-65.
    • (2001) a randomised trial , vol.358 , pp. 958-65
    • Manns, M.P.1    McHutchison, J.G.2    Gordon, S.C.3
  • 9
    • 0037179698 scopus 로고    scopus 로고
    • Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection
    • Fried MW, Shiffman ML, Reddy KR, et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002; 347: 975-82.
    • (2002) N Engl J Med , vol.347 , pp. 975-82
    • Fried, M.W.1    Shiffman, M.L.2    Reddy, K.R.3
  • 10
    • 70349292099 scopus 로고    scopus 로고
    • Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
    • Ge D, Fellay J, Thompson A, et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 2009; 461: 399-401.
    • (2009) Nature , vol.461 , pp. 399-401
    • Ge, D.1    Fellay, J.2    Thompson, A.3
  • 11
    • 70349548852 scopus 로고    scopus 로고
    • IL28B is associated with response to chronic hepatitis C interferonalpha and ribavirin therapy
    • Suppiah V, Moldovan M, Ahlenstiel G, et al. IL28B is associated with response to chronic hepatitis C interferonalpha and ribavirin therapy. Nat Genet 2009; 41: 1100-4.
    • (2009) Nat Genet , vol.41 , pp. 1100-4
    • Suppiah, V.1    Moldovan, M.2    Ahlenstiel, G.3
  • 12
    • 70349533037 scopus 로고    scopus 로고
    • Genome-wide association of IL28B with response to pegylated interferonalpha and ribavirin therapy for chronic hepatitis C
    • Tanaka Y, Nishida N, Sugiyama M, et al. Genome-wide association of IL28B with response to pegylated interferonalpha and ribavirin therapy for chronic hepatitis C. Nat Genet 2009; 41: 1105-9.
    • (2009) Nat Genet , vol.41 , pp. 1105-9
    • Tanaka, Y.1    Nishida, N.2    Sugiyama, M.3
  • 13
    • 77953881002 scopus 로고    scopus 로고
    • Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus
    • Thompson A, Muir A, Sulkowski M, et al. Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus. Gastroenterology 2010; 139: 120-29.
    • (2010) Gastroenterology , vol.139 , pp. 120-29
    • Thompson, A.1    Muir, A.2    Sulkowski, M.3
  • 14
    • 77949773445 scopus 로고    scopus 로고
    • ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C
    • Fellay J, Thompson AJ, Ge D, et al. ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C. Nature 2010; 464: 405-8.
    • (2010) Nature , vol.464 , pp. 405-8
    • Fellay, J.1    Thompson, A.J.2    Ge, D.3
  • 15
    • 78650820415 scopus 로고    scopus 로고
    • Telaprevir in combination with peginterferon and ribavirin in genotype 1 HCV treatment-naïve patients
    • Hepatology
    • Jacobson I, McHutchison J, Dusheiko G, et al. Telaprevir in combination with peginterferon and ribavirin in genotype 1 HCV treatment-naïve patients: final results of phase 3 ADVANCE study. Hepatology 2010; 52: 427A.
    • (2010) final results of phase 3 ADVANCE study , vol.52
    • Jacobson, I.1    McHutchison, J.2    Dusheiko, G.3
  • 16
    • 78650806148 scopus 로고    scopus 로고
    • Boceprevir (BOC) combined with Peginterferon alfa-2b/ribavirin (P/R) for Treatment-naïve patients with hepatitis C Virus (HCV) genotype (G) 1
    • Hepatology
    • Poordad F, McCone J, Bacon B, et al. Boceprevir (BOC) combined with Peginterferon alfa-2b/ribavirin (P/R) for Treatment-naïve patients with hepatitis C Virus (HCV) genotype (G) 1: SPRINT-2 final Results. Hepatology 2010; 52: 402A.
    • (2010) SPRINT-2 final Results , vol.52
    • Poordad, F.1    McCone, J.2    Bacon, B.3
  • 17
    • 77950817619 scopus 로고    scopus 로고
    • Telaprevir for previously treated chronic HCV infection
    • McHutchison JG, Manns MP, Muir AJ, et al. Telaprevir for previously treated chronic HCV infection. N Engl J Med 2010; 362: 1292-303.
    • (2010) N Engl J Med , vol.362 , pp. 1292-303
    • McHutchison, J.G.1    Manns, M.P.2    Muir, A.J.3
  • 18
    • 78649951984 scopus 로고    scopus 로고
    • Adda, SVR with telaprevir, peginterferon alfa-2a and ribavirin in HCV patients with well-characterized prior null response, partial response, viral breakthrough or relapse after PR
    • J Hepatol
    • Berg T, McHutchison N. Adda, SVR with telaprevir, peginterferon alfa-2a and ribavirin in HCV patients with well-characterized prior null response, partial response, viral breakthrough or relapse after PR: rollover study 107. J Hepatol 2010; 52: S2.
    • (2010) rollover study 107 , vol.52
    • Berg, T.1    McHutchison, N.2
  • 19
    • 78650803266 scopus 로고    scopus 로고
    • HCV RESPOND-2 final results: high sustained virologic response among Genotype 1 previous non-responders and relapsers to peginterferon/ribavirin when re-treated with Boceprevir plus pegintron (peginterferon alfa- 2b)/ribavirin
    • Bruce R, Bacon B, Gordon S, et al. HCV RESPOND-2 final results: high sustained virologic response among Genotype 1 previous non-responders and relapsers to peginterferon/ribavirin when re-treated with Boceprevir plus pegintron (peginterferon alfa- 2b)/ribavirin. Hepatology 2010; 52: 430A.
    • (2010) Hepatology , vol.52
    • Bruce, R.1    Bacon, B.2    Gordon, S.3
  • 20
    • 59149103099 scopus 로고    scopus 로고
    • Protease and polymerase inhibitors for the treatment of hepatitis C
    • Asselah T, Benhamou Y, Marcellin P. Protease and polymerase inhibitors for the treatment of hepatitis C. Liver Int 2009; 29 (Suppl. 1): 57-67.
    • (2009) Liver Int , vol.29 , Issue.SUPPL. 1 , pp. 57-67
    • Asselah, T.1    Benhamou, Y.2    Marcellin, P.3
  • 21
    • 77956639772 scopus 로고    scopus 로고
    • Activity of telaprevir alone or in combination with peginterferon alfa-2a and ribavirin in treatment-naïve, genotype 2 and 3, hepatitis C patients
    • J Hepatol
    • Foster G, Hézode C, Bronowicki JP, et al. Activity of telaprevir alone or in combination with peginterferon alfa-2a and ribavirin in treatment-naïve, genotype 2 and 3, hepatitis C patients: Final Results of Study C209. J Hepatol 2010; 52: S27.
    • (2010) Final Results of Study C209 , vol.52
    • Foster, G.1    Hézode, C.2    Bronowicki, J.P.3
  • 22
    • 77954722551 scopus 로고    scopus 로고
    • Combination of NS3/4a protease inhibitor ITMN-191 (R7227) with the active moiety of the NS5b inhibitors R1626 or R7128 enhances viral clearance and reduces emergence of drug-resistant variants
    • Tan H, Rajyaguru S, Wu T, et al. Combination of NS3/4a protease inhibitor ITMN-191 (R7227) with the active moiety of the NS5b inhibitors R1626 or R7128 enhances viral clearance and reduces emergence of drug-resistant variants. Hepatology 2008; 48: 1153A.
    • (2008) Hepatology , vol.48
    • Tan, H.1    Rajyaguru, S.2    Wu, T.3
  • 23
    • 33846131893 scopus 로고    scopus 로고
    • Antiviral interactions of an HCV polymerase inhibitor with an HCV protease inhibitor or interferon in vitro
    • Koev G, Dekhtyar T, Han L, et al. Antiviral interactions of an HCV polymerase inhibitor with an HCV protease inhibitor or interferon in vitro. Antiviral Res 2007; 73: 78-83.
    • (2007) Antiviral Res , vol.73 , pp. 78-83
    • Koev, G.1    Dekhtyar, T.2    Han, L.3
  • 24
    • 77954692606 scopus 로고    scopus 로고
    • Combination of two complementary mucleotide analogues PSI7977 and PSI938 effectively clears wild type and NS5b-S282T HCV replicons
    • Zennou V, Lam A, Keilman M, et al. Combination of two complementary mucleotide analogues PSI7977 and PSI938 effectively clears wild type and NS5b-S282T HCV replicons. J Hepatol 2010; 52: S400.
    • (2010) J Hepatol , vol.52
    • Zennou, V.1    Lam, A.2    Keilman, M.3
  • 25
    • 34548211949 scopus 로고    scopus 로고
    • HCV antiviral activity andresistance analysis in chronically infected chimpanzees treated with NS3/4A protease and NS513 polymerase inhibitors
    • Olsen DB, Carroll SS, Handt L, et al. HCV antiviral activity andresistance analysis in chronically infected chimpanzees treated with NS3/4A protease and NS513 polymerase inhibitors. J Hepatol 2007; 46: S298.
    • (2007) J Hepatol , vol.46
    • Olsen, D.B.1    Carroll, S.S.2    Handt, L.3
  • 26
    • 78049527728 scopus 로고    scopus 로고
    • Interferon-free oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and protease inhibitor (danoprevir/RG7227) for the treatment of chronic hepatitis C genotype 1 infection
    • Lancet
    • Gane E, Roberts S, Stedman C, et al. Interferon-free oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and protease inhibitor (danoprevir/RG7227) for the treatment of chronic hepatitis C genotype 1 infection: results of the INFORM-1 trial. Lancet 2010; 376: 1467-75.
    • (2010) results of the INFORM-1 trial , vol.376 , pp. 1467-75
    • Gane, E.1    Roberts, S.2    Stedman, C.3
  • 27
    • 0037687422 scopus 로고    scopus 로고
    • Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease
    • Foy E, Li K, Wang C, et al. Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease. Science 2003; 300: 1145-8.
    • (2003) Science , vol.300 , pp. 1145-8
    • Foy, E.1    Li, K.2    Wang, C.3
  • 28
    • 33845662689 scopus 로고    scopus 로고
    • IP-10 predicts viral response and therapeutic outcome in difficult-to-treat patients with HCV genotype 1 infection
    • Lagging M, Romero AI, Westin J, et al. IP-10 predicts viral response and therapeutic outcome in difficult-to-treat patients with HCV genotype 1 infection. Hepatology 2006; 44: 1617-25.
    • (2006) Hepatology , vol.44 , pp. 1617-25
    • Lagging, M.1    Romero, A.I.2    Westin, J.3
  • 29
    • 78650841602 scopus 로고    scopus 로고
    • Reduction of IP10, a biomarker of endogenous IFN, during therapy with two direct-acting antiviral agents (DAA-combo) in INFORM-1 suggests that reducing HCV RNA with IFN-free therapy may enhance response to Interferons. 16th International Symposium on HCV and Related Viruses, October 3-7 2009, Nice, France.
    • Shulman N, Smith P, Ipe D, et al. Reduction of IP10, a biomarker of endogenous IFN, during therapy with two direct-acting antiviral agents (DAA-combo) in INFORM-1 suggests that reducing HCV RNA with IFN-free therapy may enhance response to Interferons. 16th International Symposium on HCV and Related Viruses, October 3-7 2009, Nice, France.
    • Shulman, N.1    Smith, P.2    Ipe, D.3
  • 30
    • 41149156316 scopus 로고    scopus 로고
    • Liver gene expression signature to predict response to pegylated interferon plus ribavirin combination therapy in patients with chronic hepatitis C
    • Asselah T, Bieche I, Narguet S, et al. Liver gene expression signature to predict response to pegylated interferon plus ribavirin combination therapy in patients with chronic hepatitis C. Gut 2008; 57: 516-24.
    • (2008) Gut , vol.57 , pp. 516-24
    • Asselah, T.1    Bieche, I.2    Narguet, S.3
  • 31
    • 58149388300 scopus 로고    scopus 로고
    • Naturally occurring dominant resistant mutations to HCV protease and polymerase inhibitors in treatment-naive patients
    • Kuntzen T, Timm J, Berical A, et al. Naturally occurring dominant resistant mutations to HCV protease and polymerase inhibitors in treatment-naive patients. Hepatology 2008; 48: 1769-78.
    • (2008) Hepatology , vol.48 , pp. 1769-78
    • Kuntzen, T.1    Timm, J.2    Berical, A.3
  • 32
    • 65449171953 scopus 로고    scopus 로고
    • Telaprevir and peginterferon with or without ribavirin for chronic HCV infection
    • Hézode C, Forestier N, Dusheiko G, et al. Telaprevir and peginterferon with or without ribavirin for chronic HCV infection. N Engl J Med 2009; 360: 183-50.
    • (2009) N Engl J Med , vol.360 , pp. 183-50
    • Hézode, C.1    Forestier, N.2    Dusheiko, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.