Skin relaxation predicts neural firing rate adaptation in SAI touch receptors

2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10

Volumn , Issue , 2010, Pages 6678-6681

  Williams, Aaron L ^a   Gerling, Gregory J ^a   Wellnitz, Scott A ^b   Bourdon, Sarah M ^b   Lumpkin, Ellen A ^b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DATA SETS; DOUBLE EXPONENTIAL FUNCTIONS; FIRING FREQUENCY; FIRING RATES; FIT PARAMETERS; GENERALIZED MODELS; INDENTERS; LINEAR TRANSFORMATION; NEURAL FIRING; TIP FORCES;

LINEAR TRANSFORMATIONS; METADATA; VICKERS HARDNESS TESTING;

EXPONENTIAL FUNCTIONS;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; FEMALE; INNERVATION; MALE; MOUSE; PHYSIOLOGY; SENSORY NERVE CELL; SKIN; TOUCH;

ANIMALS; FEMALE; MALE; MICE; MODELS, BIOLOGICAL; NEURONS, AFFERENT; SKIN; TOUCH;

EID: 78650801814     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/IEMBS.2010.5626264     Document Type: Conference Paper

References (22)

1. R. B. Gorman, J. C. McDonagh, T. G. Hornby, R.M. Reinking, and D. J. Stuart, "Measurement and nature of firing rate adaptation in turtle spinal neurons," J Comp Physiol A, vol. 191, pp. 583-603, 2005.
2. B. H. Pubols, "Factors affecting cutaneous mechanoreceptor response. I. constant-force versus constant-displacement stimulation," J Neurophysiol, vol. 47, pp. 519-529, 1982.
3. J. R. Phillips and K. O. Johnson, "Tactile spatial resolution. II. Neural representation of bars, edges, and gratings in monkey primary afferents," J Neurophysiol, vol. 46, pp. 1192-1203, 1981.
4. R. S. Johansson, U. Landström, and R. Lundström, "Sensitivity to edges of mechanoreceptive afferent units innervating the glabrous skin of the human hand," Brain Res, vol. 244, pp. 27-32, 1982. (Pubitemid 12095244)
5. K. O. Johnson, "The roles and functions of cutaneous mechanoreceptors," Curr Opin in Neurobio, vol. 11, pp. 455-461, 2001.
6. A. Iggo and A. R. Muir, "The structure and function of a slowly adapting touch corpuscle in hairy skin," J Physiol, vol. 200, pp. 763-796, 1969.
7. K. W. Horch, D. Whitehorn, and P. R. Burgess, "Impulse generation in type I cutaneous mechanoreceptors," J Neurophysiol, vol. 37, pp. 267-281, 1974.
8. S. M. Maricich, S. A. Wellnitz, A. M. Nelson, D. R. Lesniak, G. J. Gerling, E. A. Lumpkin, and H. Y. Zoghbi, "Merkel cells are essential for light-touch responses," Science, vol. 324, pp. 1580-1582, 2009.
9. E. A. Lumpkin, T. Collisson, P. Parab, A. Omer-Abdalla, H. Haeberle, P. Chen, A. Doetzlhofer, P. White, A. Groves, N. Segil, and J. E. Johnson, "Math1-driven GFP expression in the developing nervous system of transgenic mice," Gene Expr Patterns, vol. 3, pp. 389-395, 2003.
10. D. Guinard, Y. Usson, C. Guillermet, and R. Saxod, "Merkel complexes of human digital skin: three dimensional imaging with confocal laser microscopy and double immunofluorescence," J Comp Neurol, vol. 398, pp. 98-104, 1998.
11. Z. Halata, M. Grim, and K. I. Baumann, "The merkel cell: morphology, developmental origin, function," Cas Lek Cesk, vol. 142, pp. 4-9, 2003.
12. B. H. Pubols and L. M. Pubols, "Tactile receptor discharge and mechanical properties of glabrous skin," Fed Proc, vol. 42, pp. 2583-2535, 1983.
13. B. H. Pubols, "Factors affecting cutaneous mechanoreceptor response. II. changes in mechanical properties of skin with repeated stimulation," J Neurophysiol, vol. 47, pp. 530-543, 1982.
14. S. A. Wellnitz, D. L. Lesniak, G. J. Gerling, and E. A. Lumpkin. "The regularity of sustained firing reveals two populations of slowly adapting touch receptors in mouse hairy skin," J. Neurophysiol, vol. 103, pp. 3378-3388, 2010.
15. B. Lynn and S. E. Carpenter, "Primary afferent units from the hairy skin of the rat hind limb," Brain Res, vol. 238, pp. 29-43, 1982.
16. M. D. Boada and C. J. Woodbury, "Physiological properties of mouse skin sensory neurons recorded intracellularly in vivo: temperature effects on somal membrane properties," J Neurophysiol, vol. 98, pp. 668-680, 2007.
17. B. Frankenhaeuser, "The effect of calcium on the myelinated nerve fibre," J. Physiol, vol. 137, pp. 245-260, 1957.
18. M. Koltzenburg, C. L. Stucky, and G. R. Lewin, "Receptive properties of mouse sensory neurons innervating hairy skin," J. Neurophysiol, vol. 78, pp. 1841-1850, 1997. (Pubitemid 27446968)
19. P. W. Reeh, "Sensory receptors in mammalian skin in an in vitro preparation," Neurosci Lett, vol. 66, pp. 141-146, 1986.
20. D. M. Cain, S. G. Khasabov, and D. A. Simone, "Response properties of mechanoreceptors and nociceptors in mouse glabrous skin: an in vivo study," J Neurophysiol, vol. 85, pp. 1561-1574, 2001.
21. W. Ge and P. S. Khalsa, "Encoding of compressive stress during indentation by slowly adapting type I mechanoreceptors in rat hairy skin," J Neurophysiol, vol. 87, pp. 1686-1693, 2002.
22. A. S. French and P. H. Torkkeli, "The power law of sensory adaptation: simulation by a model of excitability in spider mechanoreceptor neurons," Ann Biomed Eng, vol. 36, pp. 153-161, 2008.