A systematic review and meta-analysis of the fertility of patients with schizophrenia and their unaffected relatives

Acta Psychiatrica Scandinavica

Volumn 123, Issue 2, 2011, Pages 98-106

  Bundy, H ^a   Stahl, D ^a   MacCabe, J H ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Evolution; Fecundity; Fertility; Fitness; Meta analysis; Schizophrenia

Indexed keywords

FEMALE FERTILITY; FEMALE INFERTILITY; HUMAN; MALE FERTILITY; MALE INFERTILITY; META ANALYSIS (TOPIC); PARENT; PRIORITY JOURNAL; PROGENY; RELATIVE; REPRODUCTIVE HEALTH; REVIEW; SCHIZOPHRENIA; SEX DIFFERENCE; SIBLING; SYSTEMATIC REVIEW;

BIRTH RATE; CHI-SQUARE DISTRIBUTION; CONFIDENCE INTERVALS; FAMILY; FEMALE; FERTILITY; HUMANS; MALE; PARENTS; SCHIZOPHRENIA; SEX FACTORS; SIBLINGS;

EID: 78650797486     PISSN: 0001690X     EISSN: 16000447     Source Type: Journal    
DOI: 10.1111/j.1600-0447.2010.01623.x     Document Type: Review

References (36)

1. Cardno AG, Marshall EJ, Coid B et al. Heritability estimates for psychotic disorders. Arch Gen Psychiatry 1999;56:162-168.
2. Saha S, Chant D, Welham J, Mcgrath J. A systematic review of the prevalence of schizophrenia. PLoS Med 2005;2:e141.
3. Nanko S, Moridaria J. Reproductive rates in schizophrenic outpatients. Acta Psychiatr Scand 1993;87:400-404.
4. Fananas L, Bertranpetit J. Reproductive rates in families of schizophrenic patients in a case control study. Acta Psychiatr Scand 1995;91:202-204.
5. Bassett AS, Bury A, Hodgkinson KA, Honer WG. Reproductive fitness in familial schizophrenia. Schizophr Res 1996;21:151-160.
6. Srinivasan TN, Padmavati R. Fertility and schizophrenia: evidence for increased fertility in the relatives of schizophrenic patients. Acta Psychiatr Scand 1997;96:260-264.
7. Mcgrath JJ, Hearle J, Jenner L, Plant K, Drummond A, Barkla JM. The fertility and fecundity of patients with psychoses. Acta Psychiatr Scand 1999;99:441-446.
8. Delisi LE, Mesen A, Rodriquez C et al. Clinical characteristics of schizophrenia in multiply affected Spanish origin families from Costa Rica. Psychiatr Genet 2001;11:145-152.
9. Haukka J, Suvisaari J, Lonnqvist J. Fertility of patients with schizophrenia, their siblings, and the general population: a cohort study from 1950 to 1959 in Finland. Am J Psychiatry 2003;160:460-463.
10. Svensson AC, Lichtenstein P, Sandin S, Hultman CM. Fertility of first-degree relatives of patients with schizophrenia: a three generation perspective. Schizophr Res 2007;91:238-245.
11. Maccabe JH, Koupil L, Leon DA. Lifetime reproductive output over two generations in patients with psychosis and their unaffected siblings: the Uppsala 1915-1929 birth cohort multigenerational study. Psychol Med 2009;39:1667-1676.
12. Huxley J, Mayr E, Osmond H, Hoffer A. Schizophrenia as a genetic morphism. Nature 1964;204:220-221.
13. Nettle D. Strong Imagination: Madness, creativity and Human Nature. Oxford: Oxford University Press, 2001.
14. Rimmer J, Jacobsen B. Differential fertility of adopted schizophrenics and their half-siblings. Acta Psychiatr Scand 1976;54:161-166.
15. Weiser M, Reichenberg A, Werbeloff N et al. Increased number of offspring in first degree relatives of psychotic individuals: a partial explanation for the persistence of psychotic illnesses. Acta Psychiatr Scand 2009;119:466-471.
16. Buck C, Hobbs GE, Simpson H, Wanklin JM. Fertility of the sibs of schizophrenic patients. Brit J Psychiatr 1975;127:235-239.
17. Avila M, Thaker G, Adami H. Genetic epidemiology and schizophrenia: a study of reproductive fitness. Schizophr Res 2001;47:233-241.
18. Stata version 10, Statacorp (1984-2008).
19. Harris R, Bradburn M, Deeks J et al. METAN: fixed- and random- effects meta-analysis. Stata J 2008;8:3-28.
20. Friedrich JO, Adhikari NKJ, Beyene J. The ratio of means method as an alternative to mean differences for analyzing continuous variables in meta analysis: a simulation study. BMC Med Res Methodol 2008;8:32.
21. Hafner H, Maurer K, Leffler W, Reicher-Rossier A. The influence of age and sex on the onset and early course of schizophrenia. Br J Psychiatry 1993;162:80-86.
22. Leung A, Chue P. Sex differences in schizophrenia, a review of the literature. Acta Psychiatr Scand Suppl 2000;401:3-38.
23. Ritsner M, Sherina O, Ginath Y. Genetic epidemiological study of schizophrenia: reproduction behaviour. Acta Psychiatr Scand 1992;85:423-429.
24. Zelen M. Risks of cancer and families. J Natl Cancer Inst 2005;97:1556-1557.
25. Keller MC, Miller G. Resolving the paradox of common, harmful, heritable mental disorders: which evolutionary genetic models work best? Behav Brain Sci 2006;29:385-404. discussion 405-52.
26. Uher R. The role of genetic variation in the causation of mental illness: an evolution-informed framework. Mol Psychiatry 2009;14:1072-1082.
27. Sipos A, Rasmussen F, Harrison G et al. Paternal age and schizophrenia: a population based cohort study. Br Med J 2004;329:1070.
28. International Schizophrenia Consortium. Rare chromosomal deletions and duplications increase risk of schizophrenia. Nature 2008;455:237-241.
29. Walsh T, Mcclellan JM, Mccarthy SE et al. Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia. Science 2008;320:539-543.
30. Stefansson H, Rujescu D, Cichon S et al. Large recurrent microdeletions associated with schizophrenia. Nature 2008;455:232-236.
31. Xu B, Roos JL, Levy S, Van Rensburg EJ, Gogos JA, Karayiorgou M. Strong association of de novo copy number mutations with sporadic schizophrenia. Nat Genet 2008;40:880-885.
32. Burns J. The Descent of Madness: Evolutionary Origins of Psychosis and the Social Brain. London: Routledge, 2007.
33. Walsh B. Evolutionary quantitative genetics. In: Balding DJ, Bishop M, Cannings C, eds. Handbook of statistical genetics. Chichester: John Wiley and Sons, Ltd, 2003:389-438.
34. Plomin R, Haworth CMA, Davis OSP. Common disorders are quantitative traits. Nat Rev Gen 2009;10:872-878.
35. Alvarez-Lario B, Macarron-Vicente J (2010). Uric acid and evolution. Rheumatology Advance Access 2010. doi.
36. Kinney DK, Tanaka M. An evolutionary hypothesis of depression and its symptoms, adaptive value, and risk factors. J Nerv Ment Dis 2009;197:561-567.