Fertility of first-degree relatives of patients with schizophrenia: A three generation perspective

Schizophrenia Research

Volumn 91, Issue 1-3, 2007, Pages 238-245

  Svensson, Anna C ^a   Lichtenstein, Paul ^a   Sandin, Sven ^a   Hultman, Christina M ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Fertility; Offspring; Parents; Schizophrenia; Selection bias; Siblings

Indexed keywords

ADULT; ARTICLE; BIRTH RATE; CALCULATION; COHORT ANALYSIS; DATA BASE; FEMALE; FEMALE FERTILITY; FERTILITY; FOLLOW UP; HUMAN; HYPOTHESIS; MAJOR CLINICAL STUDY; MALE; POPULATION RESEARCH; PRIORITY JOURNAL; PROGENY; REGISTER; RELATIVE; REPRODUCTION; SCHIZOPHRENIA; SEX DIFFERENCE; SIBLING; STATISTICAL SIGNIFICANCE;

ADULT; AGED; AGED, 80 AND OVER; BIRTH RATE; COHORT STUDIES; FEMALE; HUMANS; INFERTILITY; MALE; MIDDLE AGED; PEDIGREE; PREVALENCE; REGISTRIES; REPRODUCTIVE BEHAVIOR; SCHIZOPHRENIA; SEX DISTRIBUTION;

EID: 33847262475     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.schres.2006.12.002     Document Type: Article

References (38)

1. Allen J.S., and Sarich V.M. Schizophrenia in an evolutionary perspective. Perspect. Biol. Med. 32 1 (1988) 132-153
2. Avila M., Thaker G., and Adami H. Genetic epidemiology and schizophrenia: a study of reproductive fitness. Schizophr. Res. 47 2-3 (2001) 233-241
3. Bassett A.S., Bury A., Hodgkinson K.A., and Honer W.G. Reproductive fitness in familial schizophrenia. Schizophr. Res. 21 3 (1996) 151-160
4. Battaglia M., and Bellodi L. Familial risks and reproductive fitness in schizophrenia. Schizophr. Bull. 22 2 (1996) 191-195
5. Buck C., Hobbs G.E., Simpson H., and Wanklin J.M. Fertility of the sibs of schizophrenic patients. Br. J. Psychiatry 127 (1975) 235-239
6. Byrne M., Agerbo E., Ewald H., Eaton W.W., and Mortensen P.B. Parental age and risk of schizophrenia: a case-control study. Arch. Gen. Psychiatry 60 7 (2003) 673-678
7. Bytheway B. A statistical trap associated with family size. J. Biosoc. Sci. 6 1 (1974) 67-72
8. Centre for Epidemiology. The Swedish Hospital Discharge Register: The National Board of Health and Welfare, 2006.
9. Dalman C., Broms J., Cullberg J., and Allebeck P. Young cases of schizophrenia identified in a national inpatient register-are the diagnoses valid?. Soc. Psychiatry Psychiatr. Epidemiol. 37 11 (2002) 527-531
10. DeLisi L.E., Mesen A., Rodriguez C., Bertheau A., LaPrade B., Llach M., Riondet S., and Razi K. Clinical characteristics of schizophrenia in multiply affected Spanish origin families from Costa Rica. Psychiatr. Genet. 11 3 (2001) 145-152
11. Ekholm B., Ekholm A., Adolfsson R., Vares M., Osby U., Sedvall G.C., and Jonsson E.G. Evaluation of diagnostic procedures in Swedish patients with schizophrenia and related psychoses. Nord. J. Psychiatry 59 6 (2005) 457-464
12. Fananas L., and Bertranpetit J. Reproductive rates in families of schizophrenic patients in a case-control study. Acta Psychiatr. Scand. 91 3 (1995) 202-204
13. Fitzmaurice G.M., Laird N.M., and Ware J.H. Applied Longitudinal Analysis (2004), Wiley 291-320
14. Harrison G., Cooper J.E., and Gancarczyk R. Changes in the administrative incidence of schizophrenia. Br. J. Psychiatry 159 (1991) 811-816
15. Haukka J., Suvisaari J., and Lonnqvist J. Fertility of patients with schizophrenia, their siblings, and the general population: a cohort study from 1950 to 1959 in Finland. Am. J. Psychiatry 160 3 (2003) 460-463
16. Hilger T., Propping P., and Haverkamp F. Is there an increase of reproductive rates in schizophrenics? III. An investigation in Nordbaden (SW Germany): results and discussion. Arch. Psychiatr. Nervenkr. 233 3 (1983) 177-186
17. Howard L.M., Kumar C., Leese M., and Thornicroft G. The general fertility rate in women with psychotic disorders. Am. J. Psychiatry 159 6 (2002) 991-997
18. Keller M.C., and Miller G. Resolving the paradox of common, harmful, heritable mental disorders: which evolutionary genetic models work best?. Behav. Brain Sci. 29 4 (2006) 385-404
19. Kristjansson E., Allebeck P., and Wistedt B. Validity of the diagnosis schizophrenia in a psychiatric inpatient register: a retrospective application of DSM-III criteria on ICD-8 diagnoses in Stockholm county. Nord. Psykiatr. Tidsskr. 41 (1987) 229-234
20. Lane A., Byrne M., Mulvany F., Kinsella A., Waddington J.L., Walsh D., Larkin C., and O'Callaghan E. Reproductive behaviour in schizophrenia relative to other mental disorders: evidence for increased fertility in men despite decreased marital rate. Acta Psychiatr. Scand. 91 4 (1995) 222-228
21. Lichtenstein P., Björk B., Hultman C.M., Scolnick E., Sklar P., and Sullivan P.F. Recurrence risks for schizophrenia in a Swedish national cohort. Psychol. Med. 36 10 (2006) 1417-1425
22. Malaspina D. Paternal factors and schizophrenia risk: de novo mutations and imprinting. Schizophr. Bull. 27 3 (2001) 379-393
23. McGrath J.J., Hearle J., Jenner L., Plant K., Drummond A., and Barkla J.M. The fertility and fecundity of patients with psychoses. Acta Psychiatr. Scand. 99 6 (1999) 441-446
24. Nanko S., and Moridaira J. Reproductive rates in schizophrenic outpatients. Acta Psychiatr. Scand. 87 6 (1993) 400-404
25. Nimgaonkar V.L. Reduced fertility in schizophrenia: here to stay?. Acta Psychiatr. Scand. 98 5 (1998) 348-353
26. Osby U., Hammar N., Brandt L., Wicks S., Thinsz Z., Ekbom A., and Sparen P. Time trends in first admissions for schizophrenia and paranoid psychosis in Stockholm County, Sweden. Schizophr. Res. 47 2-3 (2001) 247-254
27. Procopio M. Fertility and schizophrenia. Am. J. Psychiatry 161 4 (2004) 761-762 (author's reply 762)
28. Raschka L.B. Paternal age and schizophrenia in dizygotic twins. Br. J. Psychiatry 176 (2000) 400-401
29. Roth G. Study of the fertility of 300 mothers of schizophrenics. Acta Genet. Stat. Med. 9 (1959) 284-305
30. Sipos A., Rasmussen F., Harrison G., Tynelius P., Lewis G., Leon D.A., and Gunnell D. Paternal age and schizophrenia: a population based cohort study. BMJ 329 7474 (2004) 1070
31. Srinivasan T.N., and Padmavati R. Fertility and schizophrenia: evidence for increased fertility in the relatives of schizophrenic patients. Acta Psychiatr. Scand. 96 4 (1997) 260-264
32. Statistics Sweden. Multi-Generation Register 2004 - a description of contents and quality, 2005.
33. Sullivan P.F., Kendler K.S., and Neale M.C. Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch. Gen. Psychiatry 60 12 (2003) 1187-1192
34. Tamminga C.A., and Holcomb H.H. Phenotype of schizophrenia: a review and formulation. Mol. Psychiatry 10 1 (2005) 27-39
35. Waddington J.L., and Youssef H.A. Familial-genetic and reproductive epidemiology of schizophrenia in rural Ireland: age at onset, familial morbid risk and parental fertility. Acta Psychiatr. Scand. 93 1 (1996) 62-68
36. Vogel H.P. Fertility and sibship size in a psychiatric patient population. A comparison with national census data. Acta Psychiatr. Scand. 60 5 (1979) 483-503
37. Zeger S.L., Liang K.Y., and Albert P.S. Models for longitudinal data: a generalized estimating equation approach. Biometrics 44 4 (1988) 1049-1060
38. Zelen M. Risks of cancer and families. J. Natl. Cancer Inst. 97 21 (2005) 1556-1557