Urothelial neoplasms of the urinary bladder occurring in young adult and pediatric patients: A comprehensive review of literature with implications for patient management

Advances in Anatomic Pathology

Volumn 18, Issue 1, 2011, Pages 79-89

  Paner, Gladell P ^a   Zehnder, Pascal ^b,c   Amin, Anmol M ^c   Husain, Aliya N ^a   Desai, Mihir M ^c  

^a UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

^b UNIVERSITY OF BERN   (Switzerland)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Bladder cancer; carcinoma; diagnosis; management; molecular abnormalities; outcome; pediatric; prognosis; treatment; urothelial; young

Indexed keywords

FIBROBLAST GROWTH FACTOR RECEPTOR 3; PROTEIN P53;

ADOLESCENT; ADULT; BLADDER TUMOR; CANCER DIAGNOSIS; CANCER LOCALIZATION; CANCER RECURRENCE; CANCER RISK; CANCER STAGING; CHILD; CHROMOSOME 9; EPIGENETICS; HEMATURIA; HISTOPATHOLOGY; HUMAN; METASTASIS; MICROSATELLITE INSTABILITY; PAPILLARY CARCINOMA; PATIENT CARE; PRIORITY JOURNAL; PROGNOSIS; QUALITY OF LIFE; REVIEW; SYSTEMATIC REVIEW;

ADOLESCENT; ADULT; CARCINOMA; ENVIRONMENTAL EXPOSURE; EPIGENESIS, GENETIC; FEMALE; HUMANS; MALE; NEOPLASM RECURRENCE, LOCAL; PAPILLOMA; PROGNOSIS; URINARY BLADDER; URINARY BLADDER NEOPLASMS; UROTHELIUM;

EID: 78650795799     PISSN: 10724109     EISSN: 15334031     Source Type: Journal    
DOI: 10.1097/PAP.0b013e318204c0cf     Document Type: Review

References (99)

1. Jemal A, Siegel R, Xu J, et al. Cancer statistics, 2010. CA Cancer J Clin. 2010;60:277-300.
2. David KA, Mallin K, Milowsky MI, et al. Surveillance of urothelial carcinoma: Stage and grade migration, 1993-2005 and survival trends, 1993-2000. Cancer. 2009;115:1435-1447.
3. Kutarski PW, Padwell A. Transitional cell carcinoma of the bladder in young adults. Br J Urol. 1993;72:749-755.
4. Witjes JA, Debruyne FM. Bladder carcinoma in patients less than 40 years of age. Urol Int. 1989;44:81-83.
5. Migaldi M, Rossi G, Maiorana A, et al. Superficial papillary urothelial carcinomas in young and elderly patients: A comparative study. BJU Int. 2004;94:311-316.
6. Johnson DE, Hillis S. Carcinoma of the bladder in patients less than 40 years old. J Urol. 1978;120:172-173.
7. Javadpour N, Mostofi FK. Primary epithelial tumors of the bladder in the first two decades of life. J Urol. 1969;101: 706-710.
8. Alanee S, Shukla AR. Bladder malignancies in children aged <18 years: results from the surveillance, epidemiology and end results database. BJU Int. 2010;106:557-560.
9. Lerena J, Krauel L, García-Aparicio L, et al. Transitional cell carcinoma of the bladder in children and adolescents: Six-case series and review of the literature. J Pediatr Urol. 2010;6: 481-485.
10. Patel R, Tery T, Ninan GK. Transitional cell carcinoma of the bladder in first decade of life. Pediatr Surg Int. 2008;24: 1265-1268.
11. Fine SW, Humphrey PA, Dehner LP, et al. Urothelial neoplasms in patients 20 years or younger: A clinicopathological analysis using the world health organization 2004 bladder consensus classification. J Urol. 2005;174:1976-1980.
12. Paduano L, Chiella E. Primary epithelial tumors of the bladder in children. J Urol. 1988;139:794-795.
13. Benson RC Jr, Tomera KM, Kelalis PP. Transitional cell carcinoma of the bladder in children and adolescents. J Urol. 1983;130:54-55.
14. Alam S, Goebel J, Pacheco MC, et al. Papillary urothelial neoplasm of low malignant potential in a pediatric renal transplant recipient (PUNLMP): A case report. Pediatr Transplant. 2007;11:680-682.
15. Gülpinar O, Soygür T, Baltaci S, et al. Transitional cell carcinoma of bladder with lamina propria invasion in a 10-year-old boy. Urology. 2006;68:204e1-204e3.
16. Lezama-del Valle P, Jerkins GR, Rao BN, et al. Aggressive bladder carcinoma in a child. Pediatr Blood Cancer. 2004; 43:285-288.
17. Curtis M, Schned A, Hakim S, et al. Papillary transitional cell carcinoma of the bladder with lymphangiectasia in an 8-yearold boy. J Urol. 1996;156:202.
18. Keetch DW, Manley CB, Catalona WJ. Transitional cell carcinoma of bladder in children and adolescents. Urology. 1993;42:447-449.
19. Wilson-Storey D, Allen AE, Variend S. Transitional cell papillary bladder neoplasm in a girl: An unusual presentation. J Pediatr Surg. 1992;27:113-114.
20. Brumskine W, Dragan P, Sanvee L. Transitional cell carcinoma and schistosomiasis in a 5-year-old boy. Br J Urol. 1977; 49:540.
21. Chandy PC, Pai MG, Budihal MR, et al. Carcinoma of the bladder in young children: Report of 2 cases. J Urol. 1975; 113:264-265.
22. Siegel WH, Pincus MB. Epithelial bladder tumors in children. J Urol. 1969;101:55-56.
23. Firstater M, Heyman I, Loewenthal M. Bladder papilloma in a child: Case report. J Urol. 1969;101:57-58.
24. Rossi MB, Wogalter H, Spatz M. Papillary transitional cell tumor of bladder in a 5-year-old boy. J Urol. 1967;97:88-89.
25. Lowry EC, Soanes WA, Forbes KA. Carcinoma of the bladder in children; case report. J Urol. 1955;73:307-310.
26. Yossepowitch O, Dalbagni G. Transitional cell carcinoma of the bladder in young adults: Presentation, natural history and outcome. J Urol. 2002;168:61-66.
27. Wan J, Grossman HB. Bladder carcinoma in patients age 40 years or younger. Cancer. 1989;64:178-181.
28. Kurz KR, Pitts WR, Vaughan ED Jr. The natural history of patients less than 40 years old with bladder tumors. J Urol. 1987;137:395-397.
29. Madgar I, Goldwasser B, Nativ O, et al. Long-term followup of patients less than 30 years old with transitional cell carcinoma of bladder. J Urol. 1988;139:933-934.
30. Fitzpatrick JM, Reda M. Bladder carcinoma in patients 40 years old or less. J Urol. 1986;135:53-54.
31. Wild PJ, Giedl J, Stoehr R, et al. Genomic aberrations are rare in urothelial neoplasms of patients 19 years or younger. J Pathol. 2007;211:18-25.
32. Mongiat-Artus P, Miquel C, van der Aa M, et al. Infrequent microsatellite instability in urothelial cell carcinoma of the bladder in young patients. Eur Urol. 2006;49:685-690.
33. Migaldi M, Sartori G, Rossi G, et al. Prevalence and prognostic significance of microsatellite alterations in young patients with bladder cancer. Mod Pathol. 2005;18:1176-1186.
34. Christensen M, Jensen MA, Wolf H, et al. Pronounced microsatellite instability in transitional cell carcinomas from young patients with bladder cancer. Int J Cancer. 1998;79: 396-401.
35. Linn JF, Sesterhenn I, Mostofi FK, et al. The molecular characteristics of bladder cancer in young patients. J Urol. 1998;159:1493-1496.
36. Wen YC, Kuo JY, Chen KK, et al. Urothelial carcinoma of the urinary bladder in young adults-clinical experience at Taipei Veterans General Hospital. J Chin Med Assoc. 2005;68: 272-275.
37. Iori F, De Dominicis C, Liberti M, et al. Superficial bladder tumors in patients under 40 years of age: Clinical, prognostic and cytogenetic aspects. Urol Int. 2001;67:224-227.
38. Ozbey I, Aksoy Y, Biçgi O, et al. Transitional cell carcinoma of the bladder in patients under 40 years of age. Int Urol Nephrol. 1999;31:655-659.
39. Erözenci A, Ataus S, Pekyalçin A, et al. Transitional cell carcinoma of the bladder in patients under 40 years of age. Int Urol Nephrol. 1994;26:179-182.
40. Chang SY, Ma CP. Transitional cell carcinoma of the urinary bladder in patients under 40 years of age. Br J Urol. 1987;60: 343-344.
41. Hoenig DM, McRae S, Chen SC, et al. Transitional cell carcinoma of the bladder in the pediatric patient. J Urol. 1996; 156:203-205.
42. McCarthy JP, Gavrell GJ, LeBlanc GA. Transitional cell carcinoma of bladder in patients under thirty years of age. Urology. 1979;13:487-489.
43. McGuire EJ, Weiss RM, Baskin AM. Neoplasms of transitional cell origin in first twenty years of life. Urology. 1973;1: 57-59.
44. Fitch LB, Rubenstone AI. Carcinoma of the bladder in childhood. J Urol. 1962;87:549-552.
45. Cherrie RJ, Lindner A, deKernion JB. Transitional cell carcinoma of bladder in first four decades of life. Urology. 1982;20:582-584.
46. Eble JN, Sauter G, Esptein JI, et al; World Health Organization classification of tumours. Pathology and Genetics. Tumours of the Urinary System and Male Genital Organs. Albany, New York: Who Publication Center; 2004:90-157.
47. Greenfield SP, Williot P, Kaplan D. Gross hematuria in children: A ten-year review. Urology. 2007;69:166-169.
48. Klatte T, Klatte D. Invasive bladder cancer with lymphangiosis carcinomatosa and carcinoma in situ in a 19-year-old female: Case report with 21-year follow-up. Urologe A. 2007; 46:281-283.
49. Rodriguez A, Burday D, Sexton W, et al. Urothelial carcinoma in a child. Arch Esp Urol. 2005;58:473-475.
50. Kilic N, Turkel T, Balkan E, et al. Transitional cell carcinoma of the bladder presenting after blunt abdominal trauma: A very rare occurrence in childhood. Int J Urol. 2005;12:316-318.
51. Urakami S, Igawa M, Shiina H, et al. Recurrent transitional cell carcinoma in a child with the Costello syndrome. J Urol. 2002;168:1133-1134.
52. Agarwala S, Hemal AK, Seth A, et al. Transitional cell carcinoma of the urinary bladder following exposure to cyclophosphamide in childhood. Eur J Pediatr Surg. 2001;11: 207-210.
53. Scott AA, Stanley W, Worsham GF, et al. Aggressive bladder carcinoma in an adolescent: Report of a case with immunohistochemical, cytogenetic, and flow cytometric characterization. Am J Surg Pathol. 1989;13:1057-1063.
54. Oesterling JE, Epstein JI, Gearhart JP. Transitional cell carcinoma of the bladder in an adolescent with Turner's syndrome. J Urol. 1987;137:398-400.
55. Castellanos RD, Wakefield PB, Evans AT. Carcinoma of the bladder in children. J Urol. 1975;113:261-263.
56. Johnson AJ, Taylor JN. Papillary tumor of bladder in a twelveyear- old boy. J Urol. 1962;87:869-870.
57. Kohler FP. Carcinoma of the bladder in the second decade. J Urol. 1961;85:284-285.
58. Epstein JI, Amin MB, Reuter VR, et al. The World Health Organization/International Society of Urological Pathology consensus classification of urothelial (transitional cell) neoplasms of the urinary bladder: Bladder Consensus Conference Committee. Am J Surg Pathol. 1998;22:1435-1448.
59. Amin MB, McKenney JK, Tickoo SK, et al. Diagnostic Pathology. Genitourinary. Friesens, Altona, Manitoba, Canada: Amirsys Publishing, Inc.; 2010.
60. Fujii Y, Kawakami S, Koga F, et al. Long-term outcome of bladder papillary urothelial neoplasms of low malignant potential. BJU Int. 2003;92:559-562.
61. Yin H, Leong AS. Histologic grading of noninvasive papillary urothelial tumors: Validation of the 1998 WHO/ISUP system by immunophenotyping and follow-up. Am J Clin Pathol. 2004;121:679-687.
62. Samaratunga H, Makarov DV, Epstein JI. Comparison of WHO/ISUP and WHO classification of noninvasive papillary urothelial neoplasms for risk of progression. Urology. 2002;60:315-319.
63. Simo AK, Lemelle JL, Ranke A, et al. Nephrogenic adenoma of the bladder in children younger than 10 years: Report of 5 cases. Prog Urol. 2006;16:485-488.
64. Oliva E, Young RH. Nephrogenic adenoma of the urinary tract: A review of the microscopic appearance of 80 cases with emphasis on unusual features. Mod Pathol. 1995;8:722-730.
65. de Jong EA, Scholtmeijer RJ. Nephrogenic adenoma of the bladder in children. Eur Urol. 1984;10:187-190.
66. Young RH. Papillary and polypoid cystitis: A report of eight cases. Am J Surg Pathol. 1988;12:542-546.
67. Natsheh A, Prat O, Shenfeld OZ, et al. Fibroepithelial polyp of the bladder neck in children. Pediatr Surg Int. 2008;24: 613-615.
68. Sadow CA, Silverman SG, O'Leary MP, et al. Bladder cancer detection with CT urography in an Academic Medical Center. Radiology. 2008;249:195-202.
69. Kessler TM, Burkhard FC, Studer UE. Clinical indications and outcomes with nerve-sparing cystectomy in patients with bladder cancer. Urol Clin North Am. 2005;32:165-175.
70. Ong CH, Schmitt M, Thalmann GN, et al. Individualized seminal vesicle sparing cystoprostatectomy combined with ileal orthotopic bladder substitution achieves good functional results. J Urol. 2010;183:1337-1341.
71. Stein JP, Hautmann RE, Penson D, et al. Prostate-sparing cystectomy: A review of the oncologic and functional outcomes. Contraindicated in patients with bladder cancer. Urol Oncol. 2009;27:466-472.
72. Kefer JC, Campbell SC. Current status of prostate-sparing cystectomy. Urol Oncol. 2008;26:486-493.
73. Bhatta Dhar N, Kessler TM, Mills RD, et al. Nerve-sparing radical cystectomy and orthotopic bladder replacement in female patients. Eur Urol. 2007;52:1006-1014.
74. Richter J, Jiang F, Görög JP, et al. Marked genetic differences between stage pTa and stage pT1 papillary bladder cancer detected by comparative genomic hybridization. Cancer Res. 1997;57:2860-2864.
75. Simon R, Bürger H, Brinkschmidt C, et al. Chromosomal aberrations associated with invasion in papillary superficial bladder cancer. J Pathol. 1998;185:345-351.
76. Sauter G, Moch H, Carroll P, et al. Chromosome-9 loss detected by fluorescence in situ hybridization in bladder cancer. Int J Cancer. 1995;64:99-103.
77. van Rhijn BW, Montironi R, Zwarthoff EC, et al. Frequent FGFR3 mutations in urothelial papilloma. J Pathol. 2002;198: 245-251.
78. Billerey C, Chopin D, Aubriot-Lorton MH, et al. Frequent FGFR3 mutations in papillary non-invasive bladder (pTa) tumors. Am J Pathol. 2001;158:1955-1959.
79. Owen HC, Giedl J, Wild PJ, et al. Low frequency of epigenetic events in urothelial tumors in young patients. J Urol. 2010;184: 459-463.
80. Dyrskjøt L, Kruhøffer M, Thykjaer T, et al. Gene expression in the urinary bladder: A common carcinoma in situ gene expression signature exists disregarding histopathological classification. Cancer Res. 2004;64:4040-4048.
81. Oya M, Schmidt B, Schmitz-Dräger BJ, et al. Expression of G1->S transition regulatory molecules in human urothelial cancer. Jpn J Cancer Res. 1998;89:719-726.
82. Sanchez-Carbayo M, Socci ND, Lozano J, et al. Defining molecular profiles of poor outcome in patients with invasive bladder cancer using oligonucleotide microarrays. J Clin Oncol. 2006;24:778-789.
83. Zeegers MP, Tan FE, Dorant E, et al. The impact of characteristics of cigarette smoking on urinary tract cancer risk: A meta-analysis of epidemiologic studies. Cancer. 2000;89: 630-639.
84. Brennan P, Bogillot O, Cordier S, et al. Cigarette smoking and bladder cancer in men: A pooled analysis of 11 case-control studies. Int J Cancer. 2000;86:289-294.
85. Benton B, Henderson BE. Environmental exposure and bladder cancer in young males. J Natl Cancer Inst. 1973;51: 269-270.
86. Kiemeney LA, Moret NC, Witjes JA, et al. Familial transitional cell carcinoma among the population of Iceland. J Urol. 1997;157:1649-1651.
87. Purtilo DT, McCarthy B, Yang JP, et al. Familial urinary bladder cancer. Semin Oncol. 1979;6:254-256.
88. Lynch HT, Walzak MP, Fried R, et al. Familial factors in bladder carcinoma. J Urol. 1979;122:458-461.
89. Mueller CM, Caporaso N, Greene MH. Familial and genetic risk of transitional cell carcinoma of the urinary tract. Urol Oncol. 2008;26:451-464.
90. Umar A, Boland CR, Terdiman JP, et al. Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst. 2004;96:261-268. (Pubitemid 38256271)
91. Greenland JE, Weston PM, Wallace DM. Familial transitional cell carcinoma and the Lynch syndrome II. Br J Urol. 1993; 72:177-180.
92. Davis DA, Cohen PR. Genitourinary tumors in men with the Muir-Torre syndrome. J Am Acad Dermatol. 1995;33:909-912.
93. Chan H, Pratt CB. A new familial cancer syndrome? A spectrum of malignant and benign tumors including retinoblastoma, carcinoma of the bladder and other genitourinary tumors, thyroid adenoma, and a probable case of multifocal osteosarcoma. J Natl Cancer Inst. 1977;58:205-207.
94. DerKinderen DJ, Koten JW, Nagelkerke NJ, et al. Non-ocular cancer in patients with hereditary retinoblastoma and their relatives. Int J Cancer. 1988;41:499-504.
95. Sanders BM, Jay M, Draper GJ, et al. Non-ocular cancer in relatives of retinoblastoma patients. Br J Cancer. 1989;60: 358-365.
96. Aherne G. Retinoblastoma associated with other primary malignant tumours. Trans Ophthalmol Soc U K. 1974;94: 938-944.
97. Schlienger P, Campana F, Vilcoq JR, et al. Nonocular second primary tumors after retinoblastoma: Retrospective study of 111 patients treated by electron beam radiotherapy with or without TEM. Am J Clin Oncol. 2004;27:411-419.
98. Fletcher O, Easton D, Anderson K, et al. Lifetime risks of common cancers among retinoblastoma survivors. J Natl Cancer Inst. 2004;96:357-363.
99. Andreou A, Lamy A, Layet V, et al. Early-onset low-grade papillary carcinoma of the bladder associated with Apert syndrome and a germline FGFR2 mutation (Pro253Arg). Am J Med Genet A. 2006;140:2245-2247.