PMA up-regulates the transcription of Axl by AP-1 transcription factor binding to TRE sequences via the MAPK cascade in leukaemia cells

Biology of the Cell

Volumn 103, Issue 1, 2011, Pages 21-33

  Mudduluru, Giridhar ^a   Leupold, Jörg H ^a   Stroebel, Philipp ^a   Allgayer, Heike ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Activator protein 1 (AP 1); Axl promoter; PMA; Receptor tyrosine kinase

Indexed keywords

BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; CYTOSINE; GUANINE; LUCIFERASE; MITHRAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; THYMINE; TRANSCRIPTION FACTOR AP 1;

ARTICLE; AXL GENE; CANCER CELL; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENZYME ANALYSIS; GENE; GENE DELETION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MUTATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN MOTIF; TRANSACTIVATION; TRANSCRIPTION REGULATION; UPREGULATION;

BASE SEQUENCE; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LEUKEMIA; MAP KINASE SIGNALING SYSTEM; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; RESPONSE ELEMENTS; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION FACTOR AP-1; UP-REGULATION;

EID: 78650787465     PISSN: 02484900     EISSN: 1768322X     Source Type: Journal    
DOI: 10.1042/BC20100094     Document Type: Article

References (46)

1. Adiseshaiah, P., Papaiahgari, S.R., Vuong, H., Kalvakolanu, D.V. and Reddy, S.P. (2003) Multiple cis-elements mediate the transcriptional activation of human fra-1 by 12-O-tetradecanoylphorbol-13-acetate in bronchial epithelial cells. J. Biol. Chem. 278, 47423-47433
2. Adler, V., Unlap, T. and Kraft, A.S. (1994) A peptide encoding the c-Jun delta domain inhibits the activity of a c-jun amino-terminal protein kinase. J. Biol. Chem. 269, 11186-11191
3. Angel, P., Hattori, K., Smeal, T. and Karin, M. (1988) The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1. Cell 55, 875-885
4. Angel, P. and Karin, M. (1991) The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim. Biophys. Acta 1072, 129-157
5. Bergers, G., Graninger, P., Braselmann, S., Wrighton, C. and Busslinger, M. (1995) Transcriptional activation of the fra-1 gene by AP-1 is mediated by regulatory sequences in the first intron. Mol. Cell. Biol. 15, 3748-3758
6. Bernstein, L.R. and Colburn, N.H. (1989) AP1/jun function is differentially induced in promotion-sensitive and resistant JB6 cells. Science 244, 566-569
7. Budagian, V., Bulanova, E., Orinska, Z., Duitman, E., Brandt, K., Ludwig, A., Hartmann, D., Lemke, G., Saftig, P. and Bulfone-Paus, S. (2005a) Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum. Mol. Cell. Biol. 25, 9324-9339
8. Budagian, V., Bulanova, E., Orinska, Z., Thon, L., Mamat, U., Bellosta, P., Basilico, C., Adam, D., Paus, R. and Bulfone-Paus, S. Bulfone-Paus (2005b) A promiscuous liaison between IL-15 receptor and Axl receptor tyrosine kinase in cell death control. EMBO J. 24, 4260-4270 (Pubitemid 41828901)
9. Burchert, A., Attar, E.C., McCloskey, P., Fridell, Y.W. and Liu, E.T. (1998) Determinants for transformation induced by the Axl receptor tyrosine kinase. Oncogene 16, 3177-3187
10. Costa, M., Bellosta, P. and Basilico, C. (1996) Cleavage and release of a soluble form of the receptor tyrosine kinase ARK in vitro and in vivo. J. Cell Physiol. 168, 737-744
11. Craven, R.J., Xu, L.H., Weiner, T.M., Fridell, Y.W., Dent, G.A., Srivastava, S., Varnum, B., Liu, E.T. and Cance, W.G. (1995) Receptor tyrosine kinases expressed in metastatic colon cancer. Int. J. Cancer 60, 791-797
12. Demarchi, F., Verardo, R., Varnum, B., Brancolini, C. and Schneider, C. (2001) Gas6 anti-apoptotic signaling requires NF-κB activation. J. Biol. Chem. 276, 31738-31744
13. Domann, F.E., Levy, J.P., Birrer, M.J. and Bowden, G.T. (1994) Stable expression of a c-JUN deletion mutant in two malignant mouse epidermal cell lines blocks tumor formation in nude mice. Cell Growth Differ. 5, 9-16
14. Dong, Z., Birrer, M.J., Watts, R.G., Matrisian, L.M. and Colburn, N.H. (1994) Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells. Proc. Natl. Acad. Sci. U.S.A. 91, 609-613
15. Du, W., Thanos, D. and Maniatis, T. (1993) Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements. Cell 74, 887-898
16. Eferl, R. and Wagner, E.F. (2003) AP-1: a double-edged sword in tumorigenesis. Nat. Rev. Cancer 3, 859-868
17. Graham, D.K., Dawson, T.L., Mullaney, D.L., Snodgrass, H.R. and Earp, H.S. (1994) Cloning and mRNA expression analysis of a novel human protooncogene, c-mer. Cell Growth Differ. 5, 647-657
18. Hu, E., Mueller, E., Oliviero, S., Papaioannou, V.E., Johnson, R. and Spiegelman, B.M. (1994) Targeted disruption of the c-fos gene demonstrates c-fos-dependent and -independent pathways for gene expression stimulated by growth factors or oncogenes. EMBO J. 13, 3094-3103
19. Jacob, A.N., Kalapurakal, J., Davidson, W.R., Kandpal, G., Dunson, N., Prashar, Y. and Kandpal, R.P. (1999) A receptor tyrosine kinase, UFO/Axl, and other genes isolated by a modified differential display PCR are overexpressed in metastatic prostatic carcinoma cell line DU145. Cancer Detect Prev. 23, 325-332
20. Jaken, S. (1996) Protein kinase C isozymes and substrates. Curr. Opin. Cell Biol. 8, 168-173
21. Janssen, J.W., Schulz, A.S., Steenvoorden, A.C., Schmidberger, M., Strehl, S., Ambros, P.F. and Bartram, C.R. (1991) A novel putative tyrosine kinase receptor with oncogenic potential. Oncogene 6, 2113-2120
22. Kast, C., Wang, M. and Whiteway, M. (2003) The ERK/MAPK pathway regulates the activity of the human tissue factor pathway inhibitor-2 promoter. J. Biol. Chem. 278, 6787-6794
23. Kolch, W., Calder, M. and Gilbert, D. (2005) When kinases meet mathematics: the systems biology of MAPK signalling. FEBS Lett. 579, 1891-1895
24. Kustikova, O., Kramerov, D., Grigorian, M., Berezin, V., Bock, E., Lukanidin, E. and Tulchinsky, E. (1998) Fra-1 induces morphological transformation and increases in vitro invasiveness and motility of epithelioid adenocarcinoma cells. Mol. Cell. Biol. 18, 7095-7105
25. Lai, C., Gore, M. and Lemke, G. (1994) Structure, expression, and activity of Tyro 3, a neural adhesion-related receptor tyrosine kinase. Oncogene 9, 2567-2578
26. Leupold, J.H., Asangani, I., Maurer, G.D., Lengyel, E., Post, S. and Allgayer, H. (2007) Src induces urokinase receptor gene expression and invasion/intravasation via activator protein-1/p-c-Jun in colorectal cancer. Mol. Cancer Res. 5, 485-496
27. Meric, F., Lee, W.P., Sahin, A., Zhang, H., Kung, H.J. and Hung, M.C. (2002) Expression profile of tyrosine kinases in breast cancer. Clin. Cancer Res. 8, 361-367
28. Minden, A. and Karin, M. (1997) Regulation and function of the JNK subgroup of MAP kinases. Biochim. Biophys. Acta 1333, F85-F104
29. Mudduluru, G. and Allgayer, H. (2008) The human receptor tyrosine kinase Axl gene - promoter characterization and regulation of constitutive expression by Sp1, Sp3 and CpG methylation. Biosci. Rep. 28, 161-176
30. Mudduluru, G., Vajkoczy, P. and Allgayer, H. (2010) Myeloid zinc finger 1 induces migration, invasion, and in vivo metastasis through Axl gene expression in solid cancer. Mol. Cancer Res. 8, 159-169
31. Neubauer, A., Fiebeler, A., Graham, D.K., O'Bryan, J.P., Schmidt, C.A., Barckow, P., Serke, S., Siegert, W., Sndograss, H.R., Huhn, D. et al. (1994) Expression of axl, a transforming receptor tyrosine kinase, in normal and malignant hematopoiesis. Blood 84, 1931-1941
32. O'Bryan, J.P., Frye, R.A., Cogswell, P.C., Neubauer, A., Kitch, B., Prokop, C., Espinosa, 3rd, R., Le Beau, M.M., Earp, H.S. and Liu, E.T. (1991) Axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. Mol. Cell Biol. 11, 5016-5031
33. Papavassiliou, A.G., Treier, M. and Bohmann, D. (1995) Intramolecular signal transduction in c-Jun. EMBO J. 14, 2014-2019
34. Parekh, D.B., Ziegler, W. and Parker, P.J. (2000) Multiple pathways control protein kinase C phosphorylation. EMBO J. 19, 496-503 (Pubitemid 30093722)
35. Pulverer, B.J., Kyriakis, J.M., Avruch, J., Nikolakaki, E. and Woodgett, J.R. (1991) Phosphorylation of c-jun mediated by MAP kinases. Nature 353, 670-674
36. Rubinfeld, H. and Seger, R. (2004) The ERK cascade as a prototype of MAPK signaling pathways. Methods Mol. Biol. 250, 1-28
37. Shaulian, E. and Karin, M. (2002) AP-1 as a regulator of cell life and death. Nat. Cell Biol. 4, E131-E136
38. Shieh, Y.S., Lai, C.Y., Kao, Y.R., Shiah, S.G., Chu, Y.W., Lee, H.S. and Wu, C.W. (2005) Expression of axl in lung adenocarcinoma and correlation with tumor progression. Neoplasia 7, 1058-1064
39. Shin, M., Yan, C. and Boyd, D. (2002) An inhibitor of c-jun amino terminal kinase (SP600125) represses c-Jun activation, DNA-binding and PMA-inducible 92-kDa type IV collagenase expression. Biochim. Biophys. Acta 1589, 311-316
40. Stein, B., Baldwin, Jr, A.S., Ballard, D.W., Greene, W.C., Angel, P. and Herrlich, P. (1993) Cross-coupling of the NF-κB p65 and Fos/Jun transcription factors produces potentiated biological function. EMBO J. 12, 3879-3891
41. Sun, W.S., Fujimoto, J. and Tamaya, T. (2003) Coexpression of growth arrest-specific gene 6 and receptor tyrosine kinases Axl and Sky in human uterine endometrial cancers. Ann. Oncol. 14, 898-906
42. Vajkoczy, P., Knyazev, P., Kunkel, A., Capelle, H.H., Behrndt, S., von Tengg-Kobligk, H., Kiessling, F., Eichelsbacher, U., Essig, M., Read, T.A. et al. (2006) Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival. Proc. Natl. Acad. Sci. U.S.A. 103, 5799-5804
43. Weiner, T.M., Liu, E.T., Craven, R.J. and Cance, W.G. (1994) Expression of growth factor receptors, the focal adhesion kinase, and other tyrosine kinases in human soft tissue tumors. Ann. Surg. Oncol. 1, 18-27
44. Won, J.S., Song, D.K., Kim, Y.H., Huh, S.O. and Suh, H.W. (1998) The stimulation of rat astrocytes with phorbol-12-myristate-13-acetate increases the proenkephalin mRNA: involvement of proto-oncogenes. Brain Res. Mol. Brain Res. 54, 288-297
45. Wu, C.W., Li, A.F., Chi, C.W., Lai, C.H., Huang, C.L., Lo, S.S., Lui, W.Y. and Lin, W.C. (2002) Clinical significance of AXL kinase family in gastric cancerAnticancer Res. 22, 1071-1078
46. Zenz, R., Scheuch, H., Martin, P., Frank, C., Eferl, R., Kenner, L., Sibilia, M. and Wagner, E.F. (2003) c-Jun regulates eyelid closure and skin tumor development through EGFR signaling. Dev. Cell 4, 879-889