Effect of the α2-adrenoceptor antagonist yohimbine on vascular regulation of the middle cerebral artery and the ophthalmic artery in healthy subjects

Microvascular Research

Volumn 81, Issue 1, 2011, Pages 117-122

  Kaya, S ^a   Kolodjaschna, J ^a   Berisha, F ^a   Polska, E ^a   Pemp, B ^a   Garhofer G ^a   Schmetterer, L ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Receptors; Baroreflex; Ocular bloodflow; Vascular regulation

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; YOHIMBINE;

ADULT; ARTICLE; BLOOD FLOW VELOCITY; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; HUMAN; HUMAN EXPERIMENT; MALE; MIDDLE CEREBRAL ARTERY; NORMAL HUMAN; OPHTHALMIC ARTERY; PERFUSION PRESSURE; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; REGULATORY MECHANISM; SYSTOLIC BLOOD PRESSURE; VASOCONSTRICTION; VASODILATATION;

ADRENERGIC ALPHA-2 RECEPTOR ANTAGONISTS; ADULT; BLOOD FLOW VELOCITY; BLOOD PRESSURE; DOUBLE-BLIND METHOD; HUMANS; MALE; MIDDLE CEREBRAL ARTERY; OPHTHALMIC ARTERY; RECEPTORS, ADRENERGIC, ALPHA-2; VASCULAR RESISTANCE; VASOCONSTRICTION; YOHIMBINE; YOUNG ADULT;

EID: 78650771585     PISSN: 00262862     EISSN: 10959319     Source Type: Journal    
DOI: 10.1016/j.mvr.2010.10.001     Document Type: Article

References (33)

1. Aaslid R., et al. Cerebral autoregulation dynamics in humans. Stroke 1989, 20:45-52.
2. Adler F.H., et al. Observations on the physiology of the aqueous in completely iridectomized eyes. Trans. Am. Ophthalmol. Soc. 1942, 40:245-253.
3. Alm A. The effect of sympathetic stimulation on blood flow through t, e uvea, retina and optic nerve in monkeys (Macacca irus). Exp. Eye Res. 1977, 25:19-24.
4. Bhattacharya S.K., et al. Effect of aromatic amino acids, pentylenetetrazole and yohimbine on isatin and tribulin activity in rat brain. Neurosci. Lett. 1991, 132:44-46.
5. Bos W.J., et al. The reliability of noninvasive continuous finger blood pressure measurement in patients with both hypertension and vascular disease. Am. J. Hypertens. 1992, 5:529-535.
6. Charney D.S., et al. Assessment of alpha 2 adrenergic autoreceptor function in humans: effects of oral yohimbine. Life Sci. 1982, 30:2033-2041.
7. Charney D.S., et al. Noradrenergic function in panic anxiety. Effects of yohimbine in healthy subjects and patients with agoraphobia and panic disorder. Arch. Gen. Psychiatry 1984, 41:751-763.
8. Charney D.S., et al. Neurobiological mechanisms of panic anxiety: biochemical and behavioral correlates of yohimbine-induced panic attacks. Am. J. Psychiatry 1987, 144:1030-1036.
9. Clark J.T., et al. Enhancement of sexual motivation in male rats by yohimbine. Science 1984, 225:847-849.
10. Docherty J.R., McGrath J.C. Inhibition of sympathetic transmission in rat heart by clonidine: the roles of stimulation frequency, endogenous feedback and noradrenaline re-uptake. Naunyn Schmiedebergs Arch. Pharmacol. 1979, 309:225-233.
11. Drew G.M., Whiting S.B. Evidence for two distinct types of postsynaptic alpha-adrenoceptor in vascular smooth muscle in vivo. Br. J. Pharmacol. 1979, 67:207-215.
12. Goldberg M.R., et al. Influence of yohimbine on blood pressure, autonomic reflexes, and plasma catecholamines in humans. Hypertension 1983, 5:772-778.
13. Hartmann B., Bassenge E. Noninvasive, continuous measurement of finger artery pressure with the servo-plethysmo-manometer Finapres. Herz 1989, 14:251-259.
14. Kiel J.W. Modulation of choroidal autoregulation in the rabbit. Exp. Eye Res. 1999, 69:413-429.
15. Kiel J.W., Lovell M.O. Adrenergic modulation of choroidal blood flow in the rabbit. Invest. Ophthalmol. Vis. Sci. 1996, 37:673-679.
16. Kiel J.W., Shepherd A.P. Autoregulation of choroidal blood flow in the rabbit. Invest. Ophthalmol. Vis. Sci. 1992, 33:2399-2410.
17. Kolodjaschna J., et al. Comparison of the autoregulatory mechanisms between middle cerebral artery and ophthalmic artery after thigh cuff deflation in healthy subjects. Invest. Ophthalmol. Vis. Sci. 2005, 46:636-640.
18. Koss M.C., et al. Neural activation of alpha-2 adrenoceptors in cat cutaneous vasculature. J. Pharmacol. Exp. Ther. 1991, 256:1126-1131.
19. Langer S.Z. Presence and physiological role of presynaptic inhibitory alpha 2-adrenoreceptors in guinea pig atria. Nature 1981, 294:671-672.
20. Levine B.D., Zhang R. Comments on Point:Counterpoint: Sympathetic activity does/does not influence cerebral blood flow. Autonomic control of the cerebral circulation is most important for dynamic cerebral autoregulation. J. Appl. Physiol. 2008, 105:1369-1373.
21. Nagahara M., et al. The acute effects of stellate ganglion block on circulation in human ocular fundus. Acta Ophthalmol. Scand. 2001, 79:45-48.
22. Osswald W., Guimaraes S. Adrenergic mechanisms in blood vessels: morphological and pharmacological aspects. Rev. Physiol. Biochem. Pharmacol. 1983, 96:53-122.
23. Owen J.A., et al. The pharmacokinetics of yohimbine in man. Eur. J. Clin. Pharmacol. 1987, 32:577-582.
24. Paulson O.B., et al. Cerebral autoregulation. Cerebrovasc. Brain Metab. Rev. 1990, 2:161-192.
25. Tank J., et al. Yohimbine attenuates baroreflex-mediated bradycardia in humans. Hypertension 2007, 50:899-903.
26. Timmermans P.B., van Zwieten P.A. Mini-review. The postsynaptic alpha 2-adrenoreceptor. J. Auton. Pharmacol. 1981, 1:171-183.
27. van Lieshout J.J., Secher N.H. Point:Counterpoint: Sympathetic activity does/does not influence cerebral blood flow. Point: Sympathetic activity does influence cerebral blood flow. J. Appl. Physiol. 2008, 105:1364-1366.
28. Wahl M., Schilling L. Regulation of cerebral blood flow-a brief review. Acta Neurochir. Suppl. Wien. 1993, 59:3-10.
29. Weigert G., et al. Effects of topical clonidine versus brimonidine on choroidal blood flow and intraocular pressure during squatting. Invest. Ophthalmol. Vis. Sci. 2007, 48:4220-4225.
30. Weigert G., et al. Intravenous administration of clonidine reduces intraocular pressure and alters ocular blood flow. Br. J. Ophthalmol. 2007, 91:1354-1358.
31. Wray D.W., et al. Diminished baroreflex-induced vasoconstriction following alpha-2 adrenergic receptor blockade in humans. Auton. Neurosci. 2008, 138:114-117.
32. Yonezawa A., et al. Diminution of ejaculatory capacity induced by frequent ejaculation in dogs: prevention and reversal by yohimbine. Andrologia 1991, 23:71-74.
33. Yu H.G., et al. Stellate ganglion block increases blood flow into the optic nerve head and the peripapillary retina in human. Auton. Neurosci. 2003, 109:53-57.