Diminished baroreflex-induced vasoconstriction following alpha-2 adrenergic receptor blockade in humans

Autonomic Neuroscience: Basic and Clinical

Volumn 138, Issue 1-2, 2008, Pages 114-117

  Wray, D Walter ^a,b   Raven, Peter B ^b   Sander, Mikael ^c  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

^c University of Copenhagen   (Denmark)

Author keywords

Baroreflex; Leg blood flow; Ultrasound Doppler; Yohimbine

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; YOHIMBINE;

ADRENERGIC SYSTEM; ADULT; ALPHA ADRENERGIC RECEPTOR BLOCKING; ARTERIAL PRESSURE; ARTICLE; BLOOD FLOWMETRY; CAROTID SINUS PRESSORECEPTOR REFLEX; DOPPLER FLOWMETRY; HEMODYNAMICS; HUMAN; HUMAN EXPERIMENT; LEG BLOOD FLOW; MALE; NORMAL HUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SYMPATHETIC INNERVATION; TWO DIMENSIONAL ECHOCARDIOGRAPHY; VASOCONSTRICTION;

ADRENERGIC ALPHA-ANTAGONISTS; ADULT; BAROREFLEX; BLOOD PRESSURE; CAROTID SINUS; FEMORAL ARTERY; HUMANS; LEG; MALE; PRESSORECEPTORS; RECEPTORS, ADRENERGIC, ALPHA-2; REGIONAL BLOOD FLOW; SYMPATHETIC FIBERS, POSTGANGLIONIC; ULTRASONOGRAPHY, DOPPLER, COLOR; VASOCONSTRICTION; YOHIMBINE;

EID: 38149106548     PISSN: 15660702     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.autneu.2007.11.002     Document Type: Article

References (16)

1. Anderson K.M., and Faber J.E. Differential sensitivity of arteriolar alpha 1- and alpha 2-adrenoceptor constriction to metabolic inhibition during rat skeletal muscle contraction. Circ. Res. 69 (1991) 174-184
2. Bristow J.D., Gribbin B., Honour A.J., Pickering T.G., and Sleight P. Diminished baroreflex sensitivity in high blood pressure and ageing man. J. Physiol. 202 (1969) 45P-46P
3. Brothers R.M., Haslund M.L., Wray D.W., Raven P.B., and Sander M. Exercise-induced inhibition of angiotensin ii vasoconstriction in human thigh muscle. J. Physiol. 577 (2006) 727-737
4. Buckwalter J.B., Naik J.S., Valic Z., and Clifford P.S. Exercise attenuates {alpha}-adrenergic-receptor responsiveness in skeletal muscle vasculature. J. Appl. Physiol. 90 (2001) 172-178
5. Eckberg D.L., Drabinsky M., and Braunwald E. Defective cardiac parasympathetic control in patients with heart disease. N. Engl. J. Med. 285 (1971) 877-883
6. Fadel P.J., Ogoh S., Keller D.M., and Raven P.B. Recent insights into carotid baroreflex function in humans using the variable pressure neck chamber. Exp. Physiol. 88 (2003) 671-680
7. Farrow S., Mers A., Banta G., Steigerwalt S., and Lockette W. Effect of the alpha 2-adrenergic antagonist yohimbine on orthostatic tolerance. Hypertension 15 (1990) 877-880
8. Jie K., van Brummelen P., Vermey P., Timmermans P.B., and van Zwieten P.A. Differences between exogenous and endogenous noradrenaline in the effects on vascular post-synaptic alpha 1- and alpha 2-adrenoceptors in man. J. Hypertens. Suppl 3 (1985) S145-S147
9. Keller D.M., Wasmund W.L., Wray D.W., Ogoh S., Fadel P.J., Smith M.L., and Raven P.B. Carotid baroreflex control of leg vascular conductance at rest and during exercise. J. Appl. Physiol. 94 (2003) 542-548
10. McGillivray-Anderson K.M., and Faber J.E. Effect of reduced blood flow on alpha 1- and alpha 2-adrenoceptor constriction of rat skeletal muscle microvessels. Circ. Res. 69 (1991) 165-173
11. Patakas D., Louridas G., and Kakavelas E. Reduced baroreceptor sensitivity in patients with chronic obstructive pulmonary disease. Thorax 37 (1982) 292-295
12. Pellinger T.K., and Halliwill J.R. Effect of propranolol on sympathetically mediated leg vasoconstriction in humans. J. Physiol. 583 (2007) 797-809
13. Potts J.T., Shi X.R., and Raven P.B. Carotid baroreflex responsiveness during dynamic exercise in humans. Am. J. Physiol. 265 (1993) H1928-H1938
14. Thomas G.D., and Segal S.S. Neural control of muscle blood flow during exercise. J. Appl. Physiol. 97 (2004) 731-738
15. Wray D.W., Fadel P.J., Keller D.M., Ogoh S., Sander M., Raven P.B., and Smith M.L. Dynamic carotid baroreflex control of the peripheral circulation during exercise in humans. J. Physiol. 559 (2004) 675-684
16. Wray D.W., Fadel P.J., Smith M.L., Raven P., and Sander M. Inhibition of alpha-adrenergic vasoconstriction in exercising human thigh muscles. J. Physiol. 555 (2004) 545-563