Carnosic acid prevents obesity and hepatic steatosis in ob/ob mice

Hepatology Research

Volumn 41, Issue 1, 2011, Pages 87-92

  Wang, Ting ^a   Takikawa, Yasuhiro ^a   Satoh, Takumi ^b   Yoshioka, Yoshichika ^c   Kosaka, Kunio ^d   Tatemichi, Yoshinori ^a   Suzuki, Kazuyuki ^a  

^a IWATE MEDICAL UNIVERSITY   (Japan)

^b IWATE UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d Research and Development Center   (Japan)

Author keywords

Carnosic acid; Non alcoholic fatty liver disease; Ob ob mice; Obesity

Indexed keywords

ALANINE AMINOTRANSFERASE; CARNOSIC ACID; CHOLESTEROL; GLUCOSE; LEPTIN; TRIACYLGLYCEROL;

ABDOMINAL OBESITY; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FOOD INTAKE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; HISTOPATHOLOGY; KNOCKOUT MOUSE; LIPID LIVER LEVEL; LIPID STORAGE; MALE; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; PRIORITY JOURNAL; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT REDUCTION; WHITE ADIPOSE TISSUE;

EID: 78650740072     PISSN: 13866346     EISSN: 1872034X     Source Type: Journal    
DOI: 10.1111/j.1872-034X.2010.00747.x     Document Type: Article

References (12)

1. Brunt EM. Pathology of nonalcoholic fatty liver disease. Nat Rev Gastroenterol Hepatol 2010; 7: 195-203.
2. Lewis JR, Monhanty SR. Nonalcoholic fatty liver disease: a review and update. Dig Dis Sci 2010; 55: 560-78.
3. Fabbrini E, Sullivan S, Klein S. Obesity and nonalcoholic fatty liver disease: biological, metabolic, and clinical implications. Hepatology 2010; 51: 679-89.
4. Farrell GC, Larter CZ. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology 2006; 43: 99-112.
5. Chang CY, Argo CK, Al-Osaimi AM et al. Therapy of NAFLD: antioxidants and cytoprotective angents. J Clin Gastroenterol 2006; 40: 51-60.
6. Satoh T, Izumi M, Inukai Y et al. Carnosic acid protects neuronal HT22 Cells through activation of the antioxidant-responsive element in free carboxylic acid- and catechol hydroxyl moieties-dependent manners. Neurosci Lett 2008; 434: 260-5.
7. Satoh T, Kosaka K, Itoh K et al. Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1. J Neurochem 2008; 104: 1116-31.
8. Takahashi T, Tabuchi T, Tamaki Y et al. Carnosic acid and carnosol inhibit adipocyte differentiation in mouse 3T3-L1 cells through induction of phase2 enzymes and activation of glutathione metabolism. Biochem Biophys Res Commun 2009; 382: 549-54.
9. Tamaki Y, Tabuchi T, Takahashi T et al. Activated glutathione metabolism participates in protective effects of carnosic acid against oxidative stress in neuronal HT22 cells. Planta Med 2010; 76: 683-8.
10. Kosaka K, Mimura J, Itoh K et al. Role of p62/ZIP in the neurite outgrowth by carnosic acid in PC12h cells. J Biochem 2010; 147: 73-81.
11. Zhang YK, Yeager RL, Tanaka Y et al. Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet. Toxicol Appl Pharmacol 2010; 245: 326-34.
12. Aleksunes LM, Reisman SA, Yeager RL et al. Nuclear factor erythroid 2-related factor 2 deletion impairs glucose tolerance and exacerbates hyperglycemia in type 1 diabetic mice. J Pharmacol Exp Ther 2010; 333: 140-51.