Dynasore, an inhibitor of dynamin, increases the probability of transmitter release

Neuroscience

Volumn 172, Issue , 2011, Pages 187-195

  Douthitt, H L ^a   Luo, F ^a   McCann, S D ^a   Meriney, S D ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Calcium; Dynamin; Dynasore; Neuromuscular junction; Synaptic transmission; Transmitter release

Indexed keywords

DYNAMIN; DYNASORE; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DEPRESSION; ENDOCYTOSIS; ENDPLATE POTENTIAL; EVOKED RESPONSE; EXTRACELLULAR CALCIUM; FACILITATION; FROG; NERVE STIMULATION; NEUROMUSCULAR SYNAPSE; NEUROTRANSMISSION; NONHUMAN; PRESYNAPTIC INHIBITION; PRESYNAPTIC POTENTIAL; PRIORITY JOURNAL; PROTEIN FUNCTION; STIMULUS RESPONSE; SYNAPTIC TRANSMISSION;

ACETYLCHOLINE; ANIMALS; CALCIUM; CALCIUM SIGNALING; DYNAMINS; ENDOCYTOSIS; HYDRAZONES; MINIATURE POSTSYNAPTIC POTENTIALS; MODELS, STATISTICAL; NEUROMUSCULAR JUNCTION; PRESYNAPTIC TERMINALS; RANA PIPIENS; SYNAPTIC TRANSMISSION; SYNAPTIC VESICLES;

EID: 78650738917     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2010.10.002     Document Type: Article

References (29)

1. Balaji J., Armbruster M., Ryan T.A. Calcium control of endocytic capacity at a CNS synapse. J Neurosci 2008, 28(26):6742-6749.
2. Betz W.J., Henkel A.W. Okadaic acid disrupts clusters of synaptic vesicles in frog motor nerve terminals. J Cell Biol 1994, 124(5):843-854.
3. Cho S., Meriney S.D. The effects of presynaptic calcium channel modulation by roscovitine on transmitter release at the adult frog neuromuscular junction. Eur J Neurosci 2006, 23:3200-3208.
4. Chung C., Barylko B., Leitz J., Liu X., Kavalali E.T. Acute dynamin inhibition dissects synaptic vesicle recycling pathways that drive spontaneous and evoked neurotransmission. J Neurosci 2010, 30(4):1363-1376.
5. Clayton E.L., Anggono V., Smillie K.J., Chau N., Robinson P.J., Cousin M.A. The phospho-dependent dynamin-syndapin interaction triggers activity-dependent bulk endocytosis of synaptic vesicles. J Neurosci 2009, 29(24):7706-7717.
6. Cole J.C., Villa B.R., Wilkinson R.S. Disruption of actin impedes transmitter release in snake motor terminals. J Physiol 2000, 525(Pt 3):579-586.
7. De Camilli P., Takei K., McPherson P.S. The function of dynamin in endocytosis. Curr Opin Neurobiol 1995, 5(5):559-565.
8. Katz B., Miledi R. Estimates of quantal content during "chemical potentiation" of transmitter release. Proc R Soc Lond B 1979, 205:369-378.
9. Kessels M.M., Qualmann B. The syndapin protein family: linking membrane trafficking with the cytoskeleton. J Cell Sci 2004, 117(Pt 15):3077-3086.
10. Kirchhausen T., Macia E., Pelish H.E. Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis. Methods Enzymol 2008, 438:77-93.
11. Kosaka T., Ikeda K. Possible temperature-dependent blockage of synaptic vesicle recycling induced by a single gene mutation in Drosophila. J Neurobiol 1983, 14(3):207-225.
12. Kubota M., Narita K., Murayama T., Suzuki S., Soga S., Usukura J., Ogawa Y., Kuba K. Type-3 ryanodine receptor involved in Ca2+-induced Ca2+ release and transmitter exocytosis at frog motor nerve terminals. Cell Calcium 2005, 38(6):557-567.
13. Kuo S.P., Trussell L.O. A new ion channel blooms at the synapse. Neuron 2009, 63:566-567.
14. Logiudice L., Sterling P., Matthews G. Vesicle recycling at ribbon synapses in the finely branched axon terminals of mouse retinal bipolar neurons. Neuroscience 2009, 164(4):1546-5156.
15. Lu W., Ma H., Sheng Z.H., Mochida S. Dynamin and activity regulate synaptic vesicle recycling in sympathetic neurons. J Biol Chem 2009, 284(3):1930-1937.
16. Luo F., Dittrich M., King J.D., Stiles J.R., Meriney S.D. Sub-active zone mechanisms of calcium-triggered neurotransmitter release. Soc Neurosci Abstr 2007, 33.
17. Luo F., Dittrich M., Stiles J.R., Meriney S.D. Quantitative analysis of single calcium channel openings and evoked transmitter release from active zones. Soc Neurosci Abstr 2008, 34.
18. Luo F., Dittrich M., Stiles J.R., Meriney S.D. Single pixel optical fluctuation analysis of calcium channel function in active zones. Soc Neurosci Abstr 2009, 35.
19. Macia E., Ehrlich M., Massol R., Boucrot E., Brunner C., Kirchhausen T. Dynasore, a cell-permeable inhibitor of dynamin. Dev Cell 2006, 10(6):839-850.
20. Meunier F.A., Nguyen T.H., Colasante C., Luo F., Sullivan R.K.P., Lavidis N.A., Molgo J., Meriney S.D., Schiavo G. Sustained synaptic-vesicle recycling by bulk endocytosis contributes to the maintenance of high-rate neurotransmitter release stimulated by glycerotoxin. J Cell Sci 2010, 123:1131-1140.
21. Morales M., Colicos M.A., Goda Y. Actin-dependent regulation of neurotransmitter release at central synapses. Neuron 2000, 27(3):539-550.
22. Newton A.J., Kirchhausen T., Murthy V.N. Inhibition of dynamin completely blocks compensatory synaptic vesicle endocytosis. Proc Natl Acad Sci U S A 2006, 103(47):17955-17960.
23. Obar R.A., Collins C.A., Hammarback J.A., Shpetner H.S., Vallee R.B. Molecular cloning of the microtubule-associated mechanochemical enzyme dynamin reveals homology with a new family of GTP-binding proteins. Nature 1990, 347(6290):256-261.
24. Robinson P.J., Sontag J.M., Liu J.P., Fykse E.M., Slaughter C., McMahon H., Südhof T.C. Dynamin GTPase regulated by protein kinase C phosphorylation in nerve terminals. Nature 1993, 365(6442):163-166.
25. Takei K., McPherson P.S., Schmid S.L., De Camilli P. Tubular membrane invaginations coated by dynamin rings are induced by GTP-gamma S in nerve terminals. Nature 1995, 374(6518):186-190.
26. von Gersdorff H., Matthews G. Inhibition of endocytosis by elevated internal calcium in a synaptic terminal. Nature 1994, 370(6491):652-655.
27. Wachman E., Poage R.E., Stiles J.R., Farkas D., Meriney S.D. Spatial distribution of calcium entry evoked by single action potentials within the presynaptic active zone. J Neurosci 2004, 24:2877-2885.
28. Yamada H., Abe T., Li S.A., Masuoka Y., Isoda M., Watanabe M., Nasu Y., Kumon H., Asai A., Takei K. Dynasore, a dynamin inhibitor, suppresses lamellipodia formation and cancer cell invasion by destabilizing actin filaments. Biochem Biophys Res Commun 2009, 390(4):1142-1148.
29. Yao C.K., Lin Y.Q., Ly C.V., Ohyama T., Haueter C.M., Moiseenkova-Bell V.Y., Wensel T.G., Bellen H.J. A synaptic vesicle-associated Ca2+ channel promotes endocytosis and couples exocytosis to endocytosis. Cell 2009, 138(5):947-960.