Clinical Effects and Lethal and Forensic Aspects of Propofol

Journal of Forensic Sciences

Volumn 56, Issue SUPPL. 1, 2011, Pages

  Levy, Richard J ^a  

^a GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

Death; Forensic science; Lethal; Murder; Propofol; Suicide

Indexed keywords

HYPNOTIC SEDATIVE AGENT; PROPOFOL;

ACCIDENT; ACIDOSIS; ACUTE KIDNEY FAILURE; ADDICTION; ARTICLE; BACTEREMIA; BLOOD; BRADYCARDIA; CHEMICAL STRUCTURE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DYSLIPIDEMIA; FORENSIC TOXICOLOGY; HEALTH CARE PERSONNEL; HEART ARREST; HEART FAILURE; HOMICIDE; HUMAN; HYPERTRIGLYCERIDEMIA; HYPOTENSION; INTOXICATION; METHODOLOGY; PANCREATITIS; RHABDOMYOLYSIS; SEPSIS; SUBSTANCE ABUSE; SUICIDE; SYNDROME;

ACCIDENTS; ACIDOSIS; ACUTE KIDNEY INJURY; BACTEREMIA; BRADYCARDIA; DYSLIPIDEMIAS; FORENSIC TOXICOLOGY; HEALTH PERSONNEL; HEART ARREST; HEART FAILURE; HOMICIDE; HUMANS; HYPERTRIGLYCERIDEMIA; HYPNOTICS AND SEDATIVES; HYPOTENSION; MOLECULAR STRUCTURE; OVERDOSE; PANCREATITIS; PROPOFOL; RHABDOMYOLYSIS; SEPSIS; SUBSTANCE ABUSE DETECTION; SUBSTANCE-RELATED DISORDERS; SUICIDE; SYNDROME;

EID: 78650730941     PISSN: 00221198     EISSN: 15564029     Source Type: Journal    
DOI: 10.1111/j.1556-4029.2010.01583.x     Document Type: Article

References (40)

1. Marik PE. Propofol: therapeutic indications and side-effects. Curr Pharm Des 2004;10:3639-49.
2. Abad-Santos F, Gálvez-Múgica MA, Santos MA, Novalbos J, Gallego-Sandín S, Méndez P, et al. Pharmacokinetics and pharmacodynamics of a single bolus of propofol 2% in healthy volunteers. J Clin Pharmacol 2003;43:397-405.
3. Kirby RR, Colaw JM, Douglas MM. Death from propofol: accident, suicide, or murder? Anesth Analg 2009;108:1182-4.
4. Roussin A, Montastruc JL, Lapeyre-Mestre M. Pharmacological and clinical evidences on the potential for abuse and dependence of propofol: a review of the literature. Fundam Clin Pharmacol 2007;21:459-66.
5. Schneider U, Rada D, Rollnik JD, Passie T, Emrich HM. Propofol dependency after treatment of tension headache. Addict Biol 2001;6:263-5.
6. Weetman DB, Mascardo LA, Ross MB, Abramowitz PW. Propofol as a drug of diversion. Am J Health Syst Pharm 2004;61:1185-6.
7. Bennett SN, McNeil MM, Bland LA, Arduino MJ, Villarino ME, Perrotta DM, et al. Postoperative infections traced to contamination of an intravenous anesthetic, propofol. N Engl J Med 1995;333:147-54.
8. Fong JJ, Sylvia L, Ruthazer R, Schumaker G, Kcomt M, Devlin JW. Predictors of mortality in patients with suspected propofol infusion syndrome. Crit Care Med 2008;36:2281-7.
9. Parke TJ, Stevens JE, Rice AS, Greenaway CL, Bray RJ, Smith PJ, et al. Metabolic acidosis and fatal myocardial failure after propofol infusion in children: five case reports. BMJ 1992;305:613-6.
10. Fudickar A, Bein B. Propofol infusion syndrome: update of clinical manifestation and pathophysiology. Minerva Anestesiol 2009;75:339-44.
11. Rinaldi RC, Steindler EM, Wilford BB, Goodwin D. Clarification and standardization of substance abuse terminology. JAMA 1988;259:555-7.
12. Wischmeyer PE, Johnson BR, Wilson JE, Dingmann C, Bachman HM, Roller E, et al. A survey of propofol abuse in academic anesthesia programs. Anesth Analg 2007;105:1066-71.
13. Follette JW, Farley WJ. Anesthesiologist addicted to propofol. Anesthesiology 1992;77:817-8.
14. Soyka M, Schutz CG. Propofol dependency. Addiction 1997;92:1369-70.
15. Pain L, Oberling P, Sandner G, Di Scala G. Effect of propofol on affective state as assessed by place conditioning paradigm in rats. Anesthesiology 1996;85:121-8.
16. Pain L, Oberling P, Sandner G, Di Scala G. Effect of midazolam on propofol-induced positive affective state assessed by place conditioning in rats. Anesthesiology 1997;87:935-43.
17. Le Sage MG, Stafford D, Glowa JR. Abuse liability of the anaesthetic propofol: self-administration of propofol in rats under fixed-ratio schedules of drug delivery. Psychopharmacology (Berl.) 2000;153:148-54.
18. Weerts EM, Ator NA, Griffiths RR. Comparison of the intravenous reinforcing effects of propofol and methohexital in baboons. Drug Alcohol Depend 1999;57:51-60.
19. Zacny JP, Lichtor JL, Thompson W, Apfelbaum JL. Propofol at subanaesthetic doses may have abuse potential in healthy volunteers. Anesth Analg 1993;77:544-52.
20. Uniform Controlled Substances Act: National Conference of Commissioners on Uniform State Laws; Section 309, Diversion Prevention and Control, 1994;49, .
21. Dexter F. Detecting diversion of anesthetic drugs by providers. Anesth Analg 2007;105:897-8.
22. Guitton J, Desage M, Lepape A, Degoute CS, Manchon M, Brazier JL. Quantitation of propofol in whole blood by gas chromatography-mass spectrometry. J Chromatogr B Biomed Appl 1995;669:358-65.
23. Fujita A, Higuchi J, Nagai T, Tokudome S, Sakio H. A simple method for detecting plasma propofol. Anesth Analg 2000;90:1452-4.
24. Teshima D, Nagahama H, Makino K, Kataoka Y, Oishi R. Microanalysis of propofol in human serum by semi-microcolumn high-performance liquid chromatography with UV detection and solid-phase extraction. J Clin Pharm Ther 2001;26:381-5.
25. Dowrie RH, Ebling WF, Mandema JW, Stanski DR. High-performance liquid chromatographic assay of propofol in human and rat plasma and fourteen rat tissues using electrochemical detection. J Chromatogr B Biomed Appl 1996;678:279-88.
26. Favetta P, Guitton J, Degoute CS, Van Daele L, Boulieu R. High-performance liquid chromatographic assay to detect hydroxylate and conjugate metabolites of propofol in human urine. J Chromatogr B Biomed Sci Appl 2000;742:25-35.
27. Nitsun M, Szokol JW, Saleh HJ, Murphy GS, Vender JS, Luong L, et al. Pharmacokinetics of midazolam, propofol, and fentanyl transfer to human breast milk. Clin Pharmacol Ther 2006;79:549-57.
28. Cirimele V, Kintz P, Doray S, Ludes B. Determination of chronic abuse of the anaesthetic agents midazolam and propofol as demonstrated by hair analysis. Int J Legal Med 2002;116:54-7.
29. Grossherr M, Hengstenberg A, Meier T, Dibbelt L, Igl BW, Ziegler A, et al. Propofol concentration in exhaled air and arterial plasma in mechanically ventilated patients undergoing cardiac surgery. Br J Anaesth 2009;102:608-13.
30. Bajpai L, Varshney M, Seubert CN, Dennis DM. A new method for the quantitation of propofol in human plasma: efficient solid-phase extraction and liquid chromatography/APCI-triple quadrupole mass spectrometry detection. J Chromatogr B Analyt Technol Biomed Life Sci 2004;810:291-6.
31. Cohen S, Lhuillier F, Mouloua Y, Vignal B, Favetta P, Guitton J. Quantitative measurement of propofol and in main glucuroconjugate metabolites in human plasma using solid phase extraction-liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2007;854:165-72.
32. Miekisch W, Fuchs P, Kamysek S, Neumann C, Schubert JK. Assessment of propofol concentrations in human breath and blood by means of HS-SPME-GC-MS. Clin Chim Acta 2008;395:32-7.
33. Kranioti EF, Mavroforou A, Mylonakis P, Michalodimitrakis M. Lethal self administration of propofol (Diprivan): a case report and review of the literature. Forensic Sci Int 2007;167:56-8.
34. Drummer OH. Post-mortem toxicology. Forensic Sci Int 2007;165:199-203.
35. Iwersen-Bergmann S, Rösner P, Kühnau HC, Junge M, Schmoldt A. Death after excessive propofol abuse. Int J Legal Med 2001;114:248-51.
36. Roussin A, Mirepoix M, Lassabe G, Dumestre-Toulet V, Gardette V, Montastruc JL, et al. Death related to a recreational abuse of propofol at therapeutic dose range. Br J Anaesth 2006;97:268.
37. Strehier M, Preuss J, Wollersen H, Madea B. Lethal mixed intoxication with propofol in a medical layman. Arch Kriminol 2006;217:153-60.
38. Drummer OH. A fatality due to propofol poisoning. J Forensic Sci 1992;37:1186-9.
39. Chao TC, Lo DS, Chui PP, Koh TH. The first fatal 2, 6-di-isopropylphenol (propofol) poisoning in Singapore: a case report. Forensic Sci Int 1994;66:1-7.
40. Cholbi M. Self-manslaughter and the forensic classification of self-inflicted death. J Med Ethics 2007;33:155-7.