Abuse liability of the anesthetic propofol: Self-administration of propofol in rats under fixed-ratio schedules of drug delivery

Psychopharmacology

Volumn 153, Issue 1, 2000, Pages 148-154

  LeSage, M G ^a   Stafford, D ^a   Glowa, J R ^a  

^a LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

Author keywords

Anesthetic; Fixed ratio schedule; Propofol; Rat; Self administration

Indexed keywords

METHOHEXITAL; PROPOFOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABUSE; DRUG SELF ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REINFORCEMENT;

ANESTHETICS, INTRAVENOUS; ANIMALS; CONDITIONING, OPERANT; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; METHOHEXITAL; PROPOFOL; RATS; RATS, WISTAR; REINFORCEMENT SCHEDULE; SUBSTANCE-RELATED DISORDERS;

EID: 0034494148     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130000430     Document Type: Article

References (27)

1. A receptors
2. Inhibition of dopamine transport in rat brain synaptosomes by volatile anesthetics
3. Anesthesiologist addicted to propofol
4. Infusion of propofol ('Diprivan') as sedative technique for colonoscopies
5. A receptor in rat brain
6. Recovery following propofol ("Diprivan") anaesthesia - A review of three different anaesthetic techniques
7. Diazepam self-administration and resistance to extinction
8. The actions of propofol on inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent central neurons
9. A receptor-chloride ionophore complex in dissociated hippocampal pyramidal neurons of the rat
10. Intravenous heroin and ethanol self-administration by alcohol-preferring AA and alcohol-avoiding ANA rats
11. Is inhibition of dopamine uptake relevant to the hypnotic action of i.v. anesthetics?
12. Propofol and other intravenous anesthetics have sites of action on the γ-aminobutyric acid type A receptor distinct from that of isoflurane
13. Propofol produces anticonflict action by inhibiting 5-HT release in rat dorsal hippocampus
14. Effect of propofol on affective state as assessed by place conditioning paradigm in rats
15. Effect of midazolam on propofol-induced positive affective state assessed by place conditioning
16. Biochemical and biophysiological evidence that propofol enhances GABAergic transmission in the rat brain
17. Cocaine-reinforced behavior in rats: Effects of reinforcement magnitude and fixed-ratio size
18. Characteristics of stimulant drug reinforcement
19. Methohexital-reinforced responding in rats: Effects of fixed ratio size and injection dose
20. A receptors: Influence of receptor subunits
21. Barbiturate-reinforced responding in rhesus monkeys: Comparisons of drugs with different durations of action
22. Benzodiazepines: Use, abuse and consequences
23. Drugs as reinforcers: Studies in laboratory animals
24. Maintenance of behavior by ketamine and related compounds in rhesus monkeys with different self-administration histories
25. Propofol at a subanesthetic dose may have abuse potential in healthy volunteers
26. Assessing the behavioral effects and abuse potential of propofol bolus injections in healthy volunteers