Transport mechanisms in oral transmucosal drug delivery: Implications for pain management

Mathematical Biosciences

Volumn 229, Issue 1, 2011, Pages 93-100

  Kim, Kwang Seok ^a   Simon, Laurent ^a  

^a NEW JERSEY INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Controlled release device; Diffusion; Fentanyl citrate; Transmucosal delivery

Indexed keywords

ADJACENT LAYERS; BUILT-IN FUNCTIONS; CONTROLLED RELEASE DEVICES; CUMULATIVE AMOUNT; DRUG CONCENTRATION; EXPERIMENTAL DATA; FABRICATION METHOD; FENTANYLS; GOVERNING EQUATIONS; HIGH FLUX; MATHEMATICA; PAIN MANAGEMENT; SOLUTION PROCEDURE; SOLUTION STRATEGY; SYSTEMIC CIRCULATION; TRANSMUCOSAL DELIVERY; TRANSPORT CHARACTERISTICS; TRANSPORT MECHANISM;

BODY FLUIDS; DIFFUSION; DISSOLUTION; DRUG DELIVERY; MATHEMATICAL MODELS;

ANESTHETICS;

FENTANYL CITRATE;

ANESTHETIC; BOUNDARY CONDITION; COMPUTER SIMULATION; CONCENTRATION (COMPOSITION); DIFFUSION; DISSOLUTION; MUCUS; NUMERICAL MODEL;

ARTICLE; DIFFUSION; DISSOLUTION; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG SALIVA LEVEL; DRUG TRANSPORT; LOZENGE; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; MATHEMATICAL PARAMETERS; MEMBRANE TRANSPORT; MOUTH MUCOSA; PAIN; PHARMACOKINETICS; SYSTEMIC CIRCULATION;

ADMINISTRATION, MUCOSAL; ADMINISTRATION, ORAL; ADULT; ALGORITHMS; ANALGESICS; BIOLOGICAL AVAILABILITY; BIOLOGICAL TRANSPORT; COMPUTER SIMULATION; DELAYED-ACTION PREPARATIONS; DIFFUSION; DRUG DELIVERY SYSTEMS; FENTANYL; FINITE ELEMENT ANALYSIS; HUMANS; MODELS, BIOLOGICAL; MOUTH MUCOSA; PAIN; SALIVA;

EID: 78650730742     PISSN: 00255564     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mbs.2010.11.002     Document Type: Article

References (25)

1. del Consuelo I.D., Falson F., Guy R.H., Jacques Y. Transport of fentanyl through pig buccal and esophageal epithelia in vitro influence of concentration and vehicle pH. Pharm. Res. 2005, 22:1525.
2. Rim J.E., Pinsky P.M., van Osdol W.W. Finite element modeling of coupled diffusion with partitioning in transdermal drug delivery. Ann. Biomed. Eng. 2005, 33:1422.
3. Pather S.I., Rathbone M.J., Senel S. Oral transmucosal drug delivery. Modified-Release Drug Delivery Technology 2008, vol. 1:53. Informa Healthcare, New York, NY.
4. Subbarao K., Webster R.G., Kawaoka Y., Murphy B.R., Lee Y., Chien Y.W. Oral mucosa controlled delivery of LHRH by bilayers mucoadhesive polymer systems. J. Control Release 1995, 37:251.
5. Schechter N.L., Weisman S.J., Rosenblum M.R., Bernstein B., Conard P.L. The use of oral transmucosal fentanyl citrate for painful procedures in children. Pediatrics 1995, 95:335.
6. Howell T.K., Smith S., Rushman S.C., Walker R.W.M., Radivan F. A comparison of oral transmucosal fentanyl and oral midazolam for premedication in children. Anaesthesia 2002, 57:778.
7. (accessed 15.02.10). http://ecommons.cornell.edu/handle/1813/7912.
8. Lind G., Marcus M., Mears S., Ashburn M., Peterson B., Bernhisel K., Stanley T. Oral transmucosal fentanyl citrate for analgesia and sedation in the emergency department. Ann. Emerg. Med. 1991, 20:1117.
9. Streisand J.B., Varvel J.R., Stanski D.R., Le Maire L., Ashburn M.A., Hague B.I., Tarver S.D., Stanley T.H. Absorption and bioavailability of oral transmucosal fentanyl citrate. Anesthesiology 1991, 75:223.
10. (accessed 15.02.10). http://www.actiq.com/physicians/aboutbtcp/default.asp.
11. Schutzman S.A., Liebelt E., Wisk M., Burg J. Comparison of oral transmucosal fentanyl citrate and intramuscular meperidine, promethazine, and chlorpromazine for conscious sedation of children undergoing laceration repair. Ann. Emerg. Med. 1996, 28:385.
12. Collins L.M.C., Dawes C. The surface area of the adult human mouth and thickness of the salivary film covering the teeth and oral mucosa. J. Dent. Res. 1987, 66:1300.
13. Petelin M., Šentjurc M., Stolič Z., Skalerič U. EPR study of mucoadhesive ointments for delivery of liposomes into the oral mucosa. Int. J. Pharm. 1998, 173:193.
14. Shaiova L., Lapin J., Manco L.S., Shasha D., Hu K., Harrison L., Portenoy R.K. Tolerability and effects of two formulations of oral transmucosal fentanyl citrate (OTFC; ACTIQ) in patients with radiation-induced oral mucositis. Support. Care Cancer 2004, 12:268.
15. Gainer J.L. Altering diffusivity in dilute polymeric and biological solutions. Ind. Eng. Chem. Res. 1994, 33:2341.
16. Hallworth S., Fernando R. Letters to the Editor: Density determination of bupivacaine and bupivacaine-opioid mixtures for spinal anesthesia (In Response). Anesth. Analg. 2003, 96:1230.
17. Andersson M., Axelsson A., Zacchi G. Diffusion of glucose and insulin in a swelling N-isopropylacrylamide gel. Int. J. Pharm. 1997, 157:199.
18. Wong R.C., Tse H.Y. Drugs of Abuse 2005, Humana Press Inc., Totowa, NJ.
19. (accessed 15.02.10). http://www.duragesic.com/duragesic/shared/pi/duragesic.pdf.
20. (accessed 15.02.10). http://www.drugs.com/pro/actiq.html.
21. Bredenberg S., Duberg M., Lennernäs B., Lennernäs H., Pettersson A., Westerberg M., Nyström C. In vitro and in vivo evaluation of a new sublingual tablet system for rapid oromucosal absorption using fentanyl citrate as the active substance. Eur. J. Pharm. Sci. 2003, 20:327.
22. Mazzobre M.F., Roman M.V., Mourelle A.F., Corti H.R. Octanol-water partition coefficient of glucose, sucrose, and trehalose. Carbohydr. Res. 2005, 340:207.
23. Chlou C.T. Partition coefficients of organic compounds in lipid-water systems and correlations with fish bioconcentration factors. Environ. Sci. Technol. 1985, 19:57.
24. Finlayson B.A. Nonlinear analysis in chemical engineering 1980, McGraw-Hill, New York, NY.
25. Mystakidou K., Tsilika E., Tsiatas M., Vlahos L. Oral transmucosal fentanyl citrate in cancer pain management: a practical application of nanotechnology. Int. J. Nanomed. 2007, 2:49.