Relationship between Ca2+-affinity and shielding of bulk water in the Ca2+-pump from molecular dynamics simulations

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 50, 2010, Pages 21465-21469

  Sugita, Yuji ^a,b   Ikeguchi, Mitsunori ^c   Toyoshima, Chikashi ^d  

^a RIKEN   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c YOKOHAMA CITY UNIVERSITY   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

Ion pump; Mutation; Sarco(endo)plasmic reticulum Ca2+ ATPase

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); WATER; CALCIUM; GLUTAMIC ACID; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE;

ARTICLE; ATOM; BINDING AFFINITY; BINDING SITE; CALCIUM BINDING; CHANNEL GATING; CONFORMATION; CONTROLLED STUDY; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR DYNAMICS; MUTANT; PRIORITY JOURNAL; PROTEIN STRUCTURE; SIMULATION; SURFACE PROPERTY; WILD TYPE; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; METABOLISM; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION;

BINDING SITES; CALCIUM; GLUTAMIC ACID; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; WATER;

EID: 78650724760     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1015819107     Document Type: Article

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