β-Trace protein as a diagnostic marker for perilymphatic fluid fistula: A prospective controlled pilot study to test a sample collection technique

Otology and Neurotology

Volumn 32, Issue 1, 2011, Pages 7-10

  Bachmann Harildstad, Gregor ^a   Stenklev, Niels Christian ^b   Myrvoll, Elin ^b   Jablonski, Greg ^c   Klingenberg, Olav ^c  

^a AKERSHUS UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Trace protein; Diagnosis; Fistula; Inner ear; Labyrinthine fluids; Perilymph

Indexed keywords

BIOLOGICAL MARKER; ISOMERASE; LIPOCALIN; PROSTAGLANDIN R2 D ISOMERASE; PROSTAGLANDIN R2 D-ISOMERASE;

ADULT; ARTICLE; BLOOD; CHEMISTRY; CHI SQUARE DISTRIBUTION; FEMALE; FISTULA; HUMAN; INNER EAR DISEASE; MALE; MIDDLE AGED; PERILYMPH; PHOTOMETRY; PILOT STUDY; PROSPECTIVE STUDY; STAPES SURGERY;

ADULT; BIOLOGICAL MARKERS; CHI-SQUARE DISTRIBUTION; FEMALE; FISTULA; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; LABYRINTH DISEASES; LIPOCALINS; MALE; MIDDLE AGED; NEPHELOMETRY AND TURBIDIMETRY; PERILYMPH; PILOT PROJECTS; PROSPECTIVE STUDIES; STAPES SURGERY;

EID: 78650719448     PISSN: 15317129     EISSN: 15374505     Source Type: Journal    
DOI: 10.1097/MAO.0b013e3181fc74d0     Document Type: Article

References (30)

1. Maitland CG. Perilymphatic fistula. Curr Neurol Neurosci Rep 2001;1:486-91.
2. Kvestad E, Kvaerner KJ, Mair IW. Labyrinthine fistula detection: the predictive value of vestibular symptoms and computerized tomography. Acta Otolaryngol 2001;121:622-6.
3. O'Donoghue G, Balkany T, Cohen N, et al. Meningitis and cochlear implantation. Otol Neurotol 2002;23:823-4.
4. Albera R, Canale A, Lacilla M, et al. Delayed vertigo after stapes surgery. Laryngoscope 2004;114:860-2.
5. Michel O, Petereit H, Klemm E, et al. First clinical experience with beta-trace protein (prostaglandin D synthase) as a marker for peri-lymphatic fistula. J Laryngol Otol 2005;119:765-9.
6. Hoffmann A, Conradt HS, Gross G, et al. Purification and chemical characterization of beta-trace protein from human cerebrospinal fluid: its identification as prostaglandin D synthase. J of Neurochem 1993;61:451-6.
7. Hayaishi O, Matsumura H, Urade Y. Prostaglandin D synthase is the key enzyme in the promotion of physiological sleep. J Lipid Mediat 1993;6:429-31.
8. Bachmann-Harildstad G. Diagnostic values of beta-2 transferrin and beta-trace protein as markers for cerebrospinal fluid fistula. Rhinology 2008;46:82-5.
9. Bachmann G, Nekic M, Michel O. Traces of perilymph detected in epipharyngeal fluid: perilymphatic fistula as a cause of sudden hearing loss diagnosed with beta-trace protein (prostaglandin D syn-thase) immunoelectrophoresis. J Laryngol Otol 2001;115:132-5.
10. Arrer E, Meco C, Oberascher G, et al. Beta-Trace protein as a marker for cerebrospinal fluid rhinorrhea. Clin Chem 2002;48:939-41.
11. Bassiouny M, Hirsch BE, Kelly RH, et al. Beta 2 Transferrin application in otology. Am J Otol 1992;13:552-5.
12. Bordure P, Delaroche O, Beauvillain C, et al. Perilymph fistula: diagnosis by detection of perilymph in the middle ear by beta-2 transferrin immunofixation. Ann Otolaryngol Chir Cervicofac 1994; 111:180-4.
13. Buchman CA, Luxford WM, Hirsch BE, et al. Beta-2 Transferrin assay in the identification of perilymph. Am J Otol 1999;20:174-8.
14. Delaroche O, Bordure P, Lippert E, et al. Perilymph detection by beta 2-transferrin immunoblotting assay. Application to the diagnosis of perilymphatic fistulae. Clin Chim Acta 1996;245:93-104.
15. Levenson MJ, Desloge RB, Parisier SC. Beta-2 Transferrin: limitations of use as a clinical marker for perilymph. Laryngoscope 1996;106:159-61.
16. Thalmann I, Kohut RI, Ryu J, et al. Protein profile of human peri-lymph: in search of markers for the diagnosis of perilymph fistula and other inner ear disease. Otolaryngol Head Neck Surg 1994; 111:273-80.
17. Weber PC, Bluestone CD, Kenna MA, et al. Correlation of beta-2 transferrin and middle ear abnormalities in congenital perilymphatic fistula. Am J Otol 1995;16:277-82.
18. Ikezono T, ShindoS, Sekiguchi S, et al. Cochlin-tomoprotein: a novel perilymph-specific protein and a potential marker for the diagnosis of perilymphatic fistula. Audiol Neurootol 2009;14:338-44.
19. Gehrking E, Wisst F, Remmert S, et al. Intraoperative assessment of perilymphatic fistulas with intrathecal administration of fluorescein. Laryngoscope 2002;112:1614-8.
20. Sone M, Mizuno T, Sugiura M, et al. Three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging investigation of inner ear disturbances in cases of middle ear cholesteatoma with labyrinthine fistula. Otol Neurotol 2007;28:1029-33.
21. Nakashima T, Sone M, Teranishi MA, et al. Imaging of a congenital perilymphatic fistula. Int J Pediatr Otorhinolaryngol 2003;67:421-5.
22. Rupa V, Job A, Rajshekhar V. Adult onset spontaneous CSF otorrhea with oval window fistula and recurrent meningitis: MRI findings. Otolaryngol Head Neck Surg 2001;124:344-6.
23. Morris MS, Kil J, Carvlin MJ. Magnetic resonance imaging of perilymphatic fistula. Laryngoscope 1993;103:729-33.
24. Kawata R, Urade Y, Tachibana M, Mizukoshi O. Prostaglandin synthesis by the cochlea. Prostaglandins 1988;35:173-84.
25. Tachibana M, Fex J, Urade Y, Hayaishi O. Brain-type prostaglan-din D synthase occurs in the rat cochlea. Proc Natl Acad Sci USA 1987;84:7677-80.
26. Bachmann G, Baldus SE, Nekic M, Michel O. Beta-Trace protein in human perilymph. In: Reid A, Marchbanks RJ, Ernst A, eds. Intracranial and Inner-Ear Physiology and Pathophysiology. London, UK: Whurr Publishers, Ltd., 1998:193-6.
27. Bachmann G, Djenabi U, Jungehülsing M, et al. Incidence of occult cerebrospinal fluid fistula during paranasal sinus surgery. Arch Otolaryngol Head Neck Surg 2002;128:1299-302.
28. Jordan W, Tumani H, Cohrs S, et al. Prostaglandin D synthase (beta-trace) in healthy human sleep. Sleep 2004;27:867-74.
29. Reiber H, Walther K, Althaus H. Beta-Trace protein as sensitive marker for CSF rhinorhea and CSF otorhea. Acta Neurol Scand 2003;108:359-62.
30. Reiber H. Beta-Trace protein concentration in nasal secretion: discrepancies and flaws in recent publications. Acta Neurol Scand 2004;110:339-41.