Inhibition of nuclear factor κb regresses cardiac hypertrophy by modulating the expression of extracellular matrix and adhesion molecules

Free Radical Biology and Medicine

Volumn 50, Issue 1, 2011, Pages 206-215

  Kumar, Sandeep ^a,b,c   Seqqat, Rachid ^a,b,c   Chigurupati, Sravanthi ^a,b,c   Kumar, Rajesh ^a,b,c   Baker, Kenneth M ^a,b,c   Young, David ^d   Sen, Subha ^d   Gupta, Sudhiranjan ^a,b,c  

^a TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^b SCOTT AND WHITE MEMORIAL HOSPITAL   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Cardiac fibrosis; Extracellular matrix protein; Free radicals; NF B; Pyrrolidine dithiocarbamate

Indexed keywords

CELL ADHESION MOLECULE; COLLAGEN TYPE 1; COLLAGEN TYPE 3; CONNECTIVE TISSUE GROWTH FACTOR; FIBRONECTIN; GELATINASE A; GELATINASE B; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PYRROLIDINE DITHIOCARBAMATE; RECOMBINANT SOMATOMEDIN C; TISSUE INHIBITOR OF METALLOPROTEINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DRUG MECHANISM; EXTRACELLULAR MATRIX; GENE CONTROL; GENE EXPRESSION; GENE OVEREXPRESSION; HEART FAILURE; HEART MUSCLE FIBROSIS; HEART VENTRICLE HYPERTROPHY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANTIOXIDANTS; CARDIOMEGALY; CELL ADHESION MOLECULES; DISEASE PROGRESSION; DRUG EVALUATION, PRECLINICAL; EXTRACELLULAR MATRIX PROTEINS; FEMALE; GENE EXPRESSION REGULATION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICE, TRANSGENIC; NF-KAPPA B; PROLINE; THIOCARBAMATES;

MUS; MUS MUSCULUS;

EID: 78650713349     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.10.711     Document Type: Article

References (50)

1. E.E. Creemers, J.P. Cleutjens, J.F. Smits, and M.J. Daemen Matrix metalloproteinase inhibition after myocardial infarction: a new approach to prevent heart failure? Circ. Res. 89 2001 201 210
2. J. Fielitz, S. Philipp, L.R. Herda, E. Schuch, B. Pilz, C. Schubert, V. Gunzler, R. Willenbrock, and V. Regitz-Zagrosek Inhibition of prolyl 4-hydroxylase prevents left ventricular remodelling in rats with thoracic aortic banding Eur. J. Heart Fail. 9 2007 336 342
3. J.P. Cleutjens, J.C. Kandala, E. Guarda, R.V. Guntaka, and K.T. Weber Regulation of collagen degradation in the rat myocardium after infarction J. Mol. Cell. Cardiol. 27 1995 1281 1292
4. P.C. Trackman Diverse biological functions of extracellular collagen processing enzymes J. Cell. Biochem. 96 2005 927 937
5. L.I. Smith-Mungo, and H.M. Kagan Lysyl oxidase: properties, regulation and multiple functions in biology Matrix Biol. 16 1998 387 398
6. T. Acker, J. Fandrey, and H. Acker The good, the bad and the ugly in oxygen-sensing: ROS, cytochromes and prolyl-hydroxylases Cardiovasc. Res. 71 2006 195 207
7. P. Sivakumar, S. Gupta, S. Sarkar, and S. Sen Upregulation of lysyl oxidase and MMPs during cardiac remodeling in human dilated cardiomyopathy Mol. Cell. Biochem. 307 2008 159 167
8. S. Hayashidani, H. Tsutsui, M. Ikeuchi, T. Shiomi, H. Matsusaka, T. Kubota, K. Imanaka-Yoshida, T. Itoh, and A. Takeshita Targeted deletion of MMP-2 attenuates early LV rupture and late remodeling after experimental myocardial infarction Am. J. Physiol. Heart Circ. Physiol. 285 2003 H1229 H1235
9. H.E. Kim, S.S. Dalal, E. Young, M.J. Legato, M.L. Weisfeldt, and J. D'Armiento Disruption of the myocardial extracellular matrix leads to cardiac dysfunction J. Clin. Invest. 106 2000 857 866
10. C.V. Thomas, M.L. Coker, J.L. Zellner, J.R. Handy, A.J. Crumbley III, and F.G. Spinale Increased matrix metalloproteinase activity and selective upregulation in LV myocardium from patients with end-stage dilated cardiomyopathy Circulation 97 1998 1708 1715
11. L.E. Rohde, A. Ducharme, L.H. Arroyo, M. Aikawa, G.H. Sukhova, A. Lopez-Anaya, K.F. McClure, P.G. Mitchell, P. Libby, and R.T. Lee Matrix metalloproteinase inhibition attenuates early left ventricular enlargement after experimental myocardial infarction in mice Circulation 99 1999 3063 3070
12. S. Sarkar, D.W. Leaman, S. Gupta, P. Sil, D. Young, A. Morehead, D. Mukherjee, N. Ratliff, Y. Sun, M. Rayborn, J. Hollyfield, and S. Sen Cardiac overexpression of myotrophin triggers myocardial hypertrophy and heart failure in transgenic mice J. Biol. Chem. 279 2004 20422 20434
13. P.A. Baeuerle, and D. Baltimore NF-kappa B: ten years after Cell 87 1996 13 20
14. A.S. Baldwin Jr. The NF-kappa B and I kappa B proteins: new discoveries and insights Annu. Rev. Immunol. 14 1996 649 683
15. M.J. May, and S. Ghosh Signal transduction through NF-kappa B Immunol. Today 19 1998 80 88
16. N. Maulik, M. Sato, B.D. Price, and D.K. Das An essential role of NFkappaB in tyrosine kinase signaling of p38 MAP kinase regulation of myocardial adaptation to ischemia FEBS Lett. 429 1998 365 369
17. Y.T. Xuan, X.L. Tang, S. Banerjee, H. Takano, R.C. Li, H. Han, Y. Qiu, J.J. Li, and R. Bolli Nuclear factor-kappaB plays an essential role in the late phase of ischemic preconditioning in conscious rabbits Circ. Res. 84 1999 1095 1109
18. C. Li, R.L. Kao, T. Ha, J. Kelley, I.W. Browder, and D.L. Williams Early activation of IKKbeta during in vivo myocardial ischemia Am. J. Physiol. Heart Circ. Physiol. 280 2001 H1264 1271
19. M.E. Ritchie Nuclear factor-kappaB is selectively and markedly activated in humans with unstable angina pectoris Circulation 98 1998 1707 1713
20. H. Obata, S. Biro, N. Arima, H. Kaieda, T. Kihara, H. Eto, M. Miyata, and H. Tanaka NF-kappa B is induced in the nuclei of cultured rat aortic smooth muscle cells by stimulation of various growth factors Biochem. Biophys. Res. Commun. 224 1996 27 32
21. G. Valen, G.K. Hansson, A. Dumitrescu, and J. Vaage Unstable angina activates myocardial heat shock protein 72, endothelial nitric oxide synthase, and transcription factors NFkappaB and AP-1 Cardiovasc. Res. 47 2000 49 56
22. L. Timmers, J.K. van Keulen, I.E. Hoefer, M.F. Meijs, B. van Middelaar, K. den Ouden, C.J. van Echteld, G. Pasterkamp, and D.P. de Kleijn Targeted deletion of nuclear factor kappaB p50 enhances cardiac remodeling and dysfunction following myocardial infarction Circ. Res. 104 2009 699 706
23. S. Gupta, and S. Sen Role of the NF-kappaB signaling cascade and NF-kappaB-targeted genes in failing human hearts J. Mol. Med. 83 2005 993 1004
24. S. Gupta, D. Young, and S. Sen Inhibition of NF-kappaB induces regression of cardiac hypertrophy, independent of blood pressure control, in spontaneously hypertensive rats Am. J. Physiol. Heart Circ. Physiol. 289 2005 H20 29
25. S. Gupta, D. Young, R.K. Maitra, A. Gupta, Z.B. Popovic, S.L. Yong, A. Mahajan, Q. Wang, and S. Sen Prevention of cardiac hypertrophy and heart failure by silencing of NF-kappaB J. Mol. Biol. 375 2008 637 649
26. Y. Li, T. Ha, X. Gao, J. Kelley, D.L. Williams, I.W. Browder, R.L. Kao, and C. Li NF-{kappa}B activation is required for the development of cardiac hypertrophy in vivo Am. J. Physiol. Heart Circ. Physiol. 287 2004 H1712 1720
27. S. Gupta, N.H. Purcell, A. Lin, and S. Sen Activation of nuclear factor-kappaB is necessary for myotrophin-induced cardiac hypertrophy J. Cell Biol. 159 2002 1019 1028
28. P. Chomczynski, and N. Sacchi Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction Anal. Biochem. 162 1987 156 159
29. J. Tian, M.J. Pecaut, J.M. Slater, and D.S. Gridley Spaceflight modulates expression of extracellular matrix, adhesion, and profibrotic molecules in mouse lung J. Appl. Physiol. 108 2010 162 171
30. S.C. Tyagi, S.G. Kumar, S.J. Haas, H.K. Reddy, D.J. Voelker, M.R. Hayden, T.L. Demmy, R.A. Schmaltz, and J.J. Curtis Post-transcriptional regulation of extracellular matrix metalloproteinase in human heart end-stage failure secondary to ischemic cardiomyopathy J. Mol. Cell. Cardiol. 28 1996 1415 1428
31. R. Martos, J. Baugh, M. Ledwidge, C. O'Loughlin, C. Conlon, A. Patle, S.C. Donnelly, and K. McDonald Diastolic heart failure: evidence of increased myocardial collagen turnover linked to diastolic dysfunction Circulation 115 2007 888 895
32. J.T. Peterson, H. Hallak, L. Johnson, H. Li, P.M. O'Brien, D.R. Sliskovic, T.M.A. Bocan, M.L. Coker, T. Etoh, and F.G. Spinale Matrix metalloproteinase inhibition attenuates left ventricular remodeling and dysfunction in a rat model of progressive heart failure Circulation 103 2001 2303 2309
33. A. Ducharme, S. Frantz, M. Aikawa, E. Rabkin, M. Lindsey, L.E. Rohde, F.J. Schoen, R.A. Kelly, Z. Werb, P. Libby, and R.T. Lee Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction J. Clin. Invest. 106 2000 55 62
34. 2+-dependent binding to the extracellular matrix J. Cell Biol. 109 1989 341 356
35. Y.Y. Li, C.F. McTiernan, and A.M. Feldman Interplay of matrix metalloproteinases, tissue inhibitors of metalloproteinases and their regulators in cardiac matrix remodeling Cardiovasc. Res. 46 2000 214 224
36. R.L. Pinkus, L.M. Weiner, and V. Daniel Role of oxidants and antioxidants in the induction of AP-1, NF-κB and glutathione S-transferase gene expression J. Biol. Chem. 271 1996 13422 13429
37. J. Satriano, and D. Schlondorff Activation and attenuation of transcription factor NF-κB in mouse glomerular mesenglial cells in response to TNFα, immunoglobin G and adenosine 3′5′0 cyclic monophosphate: evidence for involvement of reactive oxygen species J. Clin. Invest. 94 1994 1629 1636
38. F.W. Sunderman Sr. Therapeutic properties of sodium diethyldithiocarbamate: its role as an inhibitor in the progression of AIDS Ann. Clin. Lab. Sci. 21 1991 70 81
39. A. Mihm, J. Ennen, U. Pessara, R. Kurth, and W. Druge Inhibition of HIV-1 replication and NF-κB activity by cysteine and cysteine derivatives AIDS 5 1991 497 505
40. M. Brown, M. McGuinness, T. Wright, X. Ren, Y. Wang, G.P. Boivin, H. Hahn, A.M. Feldman, and W.K. Jones Cardiac-specific blockade of NF-kappaB in cardiac pathophysiology: differences between acute and chronic stimuli in vivo Am. J. Physiol. Heart Circ. Physiol. 289 2005 H466 476
41. Y. Higuchi, T.O. Chan, M.A. Brown, J. Zhang, B.R. DeGeorge Jr., H. Funakoshi, G. Gibson, C.F. McTiernan, T. Kubota, W.K. Jones, and A.M. Feldman Cardioprotection afforded by NF-kappaB ablation is associated with activation of Akt in mice overexpressing TNF-alpha Am. J. Physiol. Heart Circ. Physiol. 290 2006 H590 598
42. N. Kawamura, T. Kubota, S. Kawano, Y. Monden, A.M. Feldman, H. Tsutsui, A. Takeshita, and K. Sunagawa Blockade of NF-kappaB improves cardiac function and survival without affecting inflammation in TNF-alpha-induced cardiomyopathy Cardiovasc. Res. 66 2005 520 529
43. S. Kawano, T. Kubota, Y. Monden, T. Tsutsumi, T. Inoue, N. Kawamura, H. Tsutsui, and K. Sunagawa Blockade of NF-{kappa}B improves cardiac function and survival after myocardial infarction Am. J. Physiol. Heart Circ. Physiol. 291 2006 H1337 1344
44. D.J. Kouba, K.Y. Chung, T. Nishiyama, L. Vindevoghel, A. Kon, J.F. Klement, J. Uitto, and A. Mauviel Nuclear factor-kappa B mediates TNF-alpha inhibitory effect on alpha 2(I) collagen (COL1A2) gene transcription in human dermal fibroblasts J. Immunol. 162 1999 4226 4234
45. B. Stein, P.C. Cogswell, and A.S. Baldwin Jr. Functional and physical associations between NF-kappa B and C/EBP family members: a Rel domain-bZIP interaction Mol. Cell. Biol. 13 1993 3964 3974
46. J. Sanceau, D.D. Boyd, M. Seiki, and B. Bauvois Interferons inhibit tumor necrosis factor-alpha-mediated matrix metalloproteinase-9 activation via interferon regulatory factor-1 binding competition with NF-kappa B J. Biol. Chem. 277 2002 35766 35775
47. M.E. Fini, J.D. Bartlett, M. Matsubara, W.B. Rinehart, M.K. Mody, M.T. Girard, and M. Rainville The rabbit gene for 92-kDa matrix metalloproteinase: role of AP1 and AP2 in cell type-specific transcription J. Biol. Chem. 269 1994 28620 28628
48. J. Westermarck, and V.M. Kahari Regulation of matrix metalloproteinase expression in tumor invasion FASEB J. 13 1999 781 792
49. Y.P. Han, T.L. Tuan, H. Wu, M. Hughes, and W.L. Garner TNF-alpha stimulates activation of pro-MMP2 in human skin through NF-(kappa)B mediated induction of MT1-MMP J. Cell Sci. 114 2001 131 139
50. G. Murphy, H. Stanton, S. Cowell, G. Butler, V. Knauper, S. Atkinson, and J. Gavrilovic Mechanisms for pro matrix metalloproteinase activation APMIS 107 1999 38 44