The effect of S-nitrosoglutathione and L-cysteine on chloride efflux from cystic fibrosis airway epithelial cells

Experimental and Molecular Pathology

Volumn 90, Issue 1, 2011, Pages 79-83

  Servetnyk, Zhanna ^a,b   Jiang, Su ^c   Hjelte, Lena ^c   Gaston, Benjamin ^d   Roomans, Godfried M ^a,e   Dragomir, Anca ^a,f  

^a UPPSALA UNIVERSITY   (Sweden)

^b Columbia University College of Physicians and Surgeons ^*  (United States)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^d UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^e ÖREBRO UNIVERSITY   (Sweden)

^f UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Airway epithelial cells; Chloride efflux; Cystic fibrosis; L cysteine; S nitrosoglutathione

Indexed keywords

CHLORIDE; CYSTEINE; S NITROSOGLUTATHIONE;

ARTICLE; CELL ACTIVATION; CELL LEVEL; CHLORIDE TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYSTIC FIBROSIS; DRUG MECHANISM; EPITHELIUM CELL; HUMAN; HUMAN CELL; INCUBATION TIME; INTRACELLULAR TRANSPORT; RESPIRATORY EPITHELIUM; TIGHT JUNCTION;

BRONCHODILATOR AGENTS; CELL LINE; CHLORIDES; CYSTEINE; CYSTIC FIBROSIS; DRUG SYNERGISM; HUMANS; RESPIRATORY MUCOSA; S-NITROSOGLUTATHIONE; TIME FACTORS;

EID: 78650712359     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2010.10.005     Document Type: Article

References (34)

1. Andersson C., et al. S-Nitrosoglutathione induces functional DeltaF508-CFTR in airway epithelial cells. Biochem. Biophys. Res. Commun. 2002, 297:552-557.
2. Chen L., et al. DETANO and nitrated lipids increase chloride secretion across lung airway cells. Am. J. Respir. Cell Mol. Biol. 2008, 39:150-162.
3. Childers M., et al. A new model of cystic fibrosis pathology: Lack of transport of glutathione and its thiocyanate conjugates. Med. Hypotheses 2007, 68:101-112.
4. Cozens A.L., et al. CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells. Am. J. Respir. Cell Mol. Biol. 1994, 10:38-47.
5. Dragomir A., Roomans G.M. Increased chloride efflux in colchicine-resistant airway epithelial cell lines. Biochem. Pharmacol. 2004, 68:253-261.
6. Duta V., et al. Regulation of basolateral Cl(-) channels in airway epithelial cells: The role of nitric oxide. J. Membr. Biol. 2006, 213:165-174.
7. Gaston B., et al. Endogenous nitrogen oxides and bronchodilator S-nitrosothiols in human airways. Proc. Natl Acad. Sci. USA 1993, 90:10957-10961.
8. Gerard C. Biomedicine. Asthmatics breathe easier when it's SNO-ing. Science 2005, 308:1560-1561.
9. Grasemann H., et al. Decreased levels of nitrosothiols in the lower airways of patients with cystic fibrosis and normal pulmonary function. J. Pediatr. 1999, 135:770-772.
10. Howard M., et al. Mammalian osmolytes and S-nitrosoglutathione promote Delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) protein maturation and function. J. Biol. Chem. 2003, 278:35159-35167.
11. Jessen F., et al. Identification of the anion exchange protein of Ehrlich cells: A kinetic analysis of the inhibitory effects of 4, 4'-diisothiocyano-2, 2'-stilbene-disulfonic acid (DIDS) and labeling of membrane proteins with 3H-DIDS. J. Membr. Biol. 1986, 92:195-205.
12. Marozkina N.V., et al. Hsp 70/Hsp 90 organizing protein as a nitrosylation target in cystic fibrosis therapy. Proc. Natl Acad. Sci. USA 2009, 107(25):11393-11398.
13. Marsey L.L., Winpenny J.P. Bestrophin expression and function in the human pancreatic duct cell line, CFPAC-1. J. Physiol. 2009, 587:2211-2224.
14. McKernan L.N., Largen M.T. Identification of multiple-molecular-weight forms of thymocyte comitogenic activity from the monocyte/macrophage cell line RAW 264.7. Cell. Immunol. 1983, 80:84-96.
15. Motlekar N.A., et al. Modulation of gastrointestinal permeability of low-molecular-weight heparin by L-arginine: In vivo and in-vitro evaluation. J. Pharm. Pharmacol. 2006, 58:591-598.
16. Munkonge F., et al. Measurement of halide efflux from cultured and primary airway epithelial cells using fluorescence indicators. J. Cyst. Fibros. 2004, 3(Suppl 2):171-176.
17. Nilsson H., et al. A modified technique for the impregnation of lanthanum tracer to study the integrity of tight junctions on cells grown on a permeable substrate. Microsc. Res. Tech. 2006, 69:776-783.
18. Nilsson H.E., et al. CFTR and tight junctions in cultured bronchial epithelial cells. Exp. Mol. Pathol. 2010, 88:118-127.
19. Que L.G., et al. Protection from experimental asthma by an endogenous bronchodilator. Science 2005, 308:1618-1621.
20. Rochat T., et al. N-acetylcysteine inhibits Na+ absorption across human nasal epithelial cells. J. Cell. Physiol. 2004, 201:106-116.
21. Salhany J.M., et al. Kinetics of conformational changes associated with inhibitor binding to the purified band 3 transporter. Direct observation of allosteric subunit interactions. Biochemistry 1993, 32:7413-7420.
22. Salzman A.L., et al. Nitric oxide dilates tight junctions and depletes ATP in cultured Caco-2BBe intestinal epithelial monolayers. Am. J. Physiol. 1995, 268:G361-G373.
23. Servetnyk Z., et al. Activation of chloride transport in CF airway epithelial cell lines and primary CF nasal epithelial cells by S-nitrosoglutathione. Respir. Res. 2006, 7:124.
24. Shen B.Q., et al. Calu-3: A human airway epithelial cell line that shows cAMP-dependent Cl- secretion. Am. J. Physiol. 1994, 266:L493-L501.
25. Snyder A.H., et al. Acute effects of aerosolized S-nitrosoglutathione in cystic fibrosis. Am. J. Respir. Crit. Care Med. 2002, 165:922-926.
26. Utoguchi N., et al. Nitric oxide donors enhance rectal absorption of macromolecules in rabbits. Pharm. Res. 1998, 15:870-876.
27. Varelogianni G., et al. The effect of N-acetylcysteine on chloride efflux from airway epithelial cells. Cell Biol. Int. 2010, 34:245-252.
28. Wu H., et al. Genetic variation in S-nitrosoglutathione reductase (GSNOR) and childhood asthma. J. Allergy Clin. Immunol. 2007, 120:322-328.
29. Zaman K., et al. S-nitrosoglutathione increases cystic fibrosis transmembrane regulator maturation. Biochem. Biophys. Res. Commun. 2001, 284:65-70.
30. Zaman K., et al. The effect of different S-nitrosylating agents on delta F 508 CFTR expression and maturation in polarized human bronchial epithelial cells. NACFC 2004, Vol. 27. Wiley-Liss, St. Louis, MO, USA.
31. Zaman K., et al. Concentration-dependent effects of endogenous S-nitrosoglutathione on gene regulation by specificity proteins Sp3 and Sp1. Biochem. J. 2004, 380:67-74.
32. Zaman K., et al. S-nitrosylating agents: A novel class of compounds that increase cystic fibrosis transmembrane conductance regulator expression and maturation in epithelial cells. Mol. Pharmacol. 2006, 70:1435-1442.
33. Zaman K., et al. Endogenous S-nitrosoglutathione modifies 5-lipoxygenase expression in airway epithelial cells. Am. J. Respir. Cell Mol. Biol. 2006, 34:387-393.
34. Zhang Y., Hogg N. The mechanism of transmembrane S-nitrosothiol transport. Proc. Natl Acad. Sci. USA 2004, 101:7891-7896.