The first structures of T cell receptors bound to peptide-MHC

Journal of Immunology

Volumn 185, Issue 11, 2010, Pages 6391-6393

  Wucherpfennig, Kai W ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA A2 ANTIGEN; T LYMPHOCYTE RECEPTOR;

ANTIGEN EXPRESSION; ANTIGEN STRUCTURE; ARTICLE; CROSS LINKING; CRYSTAL STRUCTURE; CRYSTALLIZATION; ESCHERICHIA COLI; HUMAN; HUMAN T CELL LEUKEMIA VIRUS 1; INSECT CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIGEN PRESENTATION; BINDING SITES; HISTOCOMPATIBILITY ANTIGENS CLASS I; HISTOCOMPATIBILITY ANTIGENS CLASS II; HISTORY, 20TH CENTURY; HUMANS; MICE; PEPTIDE FRAGMENTS; PROTEIN BINDING; RECEPTORS, ANTIGEN, T-CELL;

EID: 78650674494     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1090110     Document Type: Article

References (26)

1. Bjorkman, P. J., M. A. Saper, B. Samraoui, W. S. Bennett, J. L. Strominger, and D. C. Wiley. 1987. Structure of the human class I histocompatibility antigen, HLA-A2. Nature 329:506-512.
2. Bjorkman, P. J., M. A. Saper, B. Samraoui, W. S. Bennett, J. L. Strominger, and D. C. Wiley. 1987. The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature 329:512-518.
3. Zinkernagel, R. M., and P. C. Doherty. 1974. Restriction of in vitro T cellmediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system. Nature 248:701-702.
4. Cresswell, P., N. Bangia, T. Dick, and G. Diedrich. 1999. The nature of the MHC class I peptide loading complex. Immunol. Rev. 172:21-28.
5. Garboczi, D. N., D. T. Hung, and D. C. Wiley. 1992. HLA-A2-peptide complexes: refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides. Proc. Natl. Acad. Sci. USA 89:3429-3433.
6. Fremont, D. H., M. Matsumura, E. A. Stura, P. A. Peterson, and I. A. Wilson. 1992. Crystal structures of two viral peptides in complex with murine MHC class I H-2Kb. Science 257:919-927.
7. Garcia, K. C., M. Degano, R. L. Stanfield, A. Brunmark, M. R. Jackson, P. A. Peterson, L. Teyton, and I. A. Wilson. 1996. An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex. Science 274:209-219.
8. Garboczi, D. N., U. Utz, P. Ghosh, A. Seth, J. Kim, E. A. Van Tienhoven, W. E. Biddison, and D. C. Wiley. 1996. Assembly, specific binding, and crystallization of a human TCR-alphabeta with an antigenic Tax peptide from human T lymphotropic virus type 1 and the class I MHC molecule HLA-A2. J. Immunol. 157:5403-5410.
9. Matsui, K., J. J. Boniface, P. Steffner, P. A. Reay, and M. M. Davis. 1994. Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness. Proc. Natl. Acad. Sci. USA 91:12862-12866.
10. Luescher, I. F., F. Anjuère, M. C. Peitsch, C. V. Jongeneel, J. C. Cerottini, and P. Romero. 1995. Structural analysis of TCR-ligand interactions studied on H-2Kd-restricted cloned CTL specific for a photoreactive peptide derivative. Immunity 3:51-63.
11. Garboczi, D. N., P. Ghosh, U. Utz, Q. R. Fan, W. E. Biddison, and D. C. Wiley. 1996. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature 384:134-141.
12. Kranz, D. M., S. Tonegawa, and H. N. Eisen. 1984. Attachment of an anti-receptor antibody to non-target cells renders them susceptible to lysis by a clone of cytotoxic T lymphocytes. Proc. Natl. Acad. Sci. USA 81:7922-7926.
13. Sun, R., S. E. Shepherd, S. S. Geier, C. T. Thomson, J. M. Sheil, and S. G. Nathenson. 1995. Evidence that the antigen receptors of cytotoxic T lymphocytes interact with a common recognition pattern on the H-2Kb molecule. Immunity 3:573-582.
14. Bjorkman, P. J., and M. M. Davis. 1989. Model for the interaction of T-cell receptors with peptide/MHC complexes. Cold Spring Harb. Symp. Quant. Biol. 54:365-373.
15. Jorgensen, J. L., U. Esser, B. Fazekas de St Groth, P. A. Reay, and M. M. Davis. 1992. Mapping T-cell receptor-peptide contacts by variant peptide immunization of single-chain transgenics. Nature 355:224-230.
16. Baker, B. M., R. V. Turner, S. J. Gagnon, D. C. Wiley, and W. E. Biddison. 2001. Identification of a crucial energetic footprint on the alpha1 helix of human histocompatibility leukocyte antigen (HLA)-A2 that provides functional interactions for recognition by tax peptide/HLA-A2-specific T cell receptors. J. Exp. Med. 193:551-562.
17. Manning, T. C., C. J. Schlueter, T. C. Brodnicki, E. A. Parke, J. A. Speir, K. C. Garcia, L. Teyton, I. A. Wilson, and D. M. Kranz. 1998. Alanine scanning mutagenesis of an alphabeta T cell receptor: mapping the energy of antigen recognition. Immunity 8:413-425.
18. Feng, D., C. J. Bond, L. K. Ely, J. Maynard, and K. C. Garcia. 2007. Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon.' Nat. Immunol. 8:975-983.
19. Dai, S., E. S. Huseby, K. Rubtsova, J. Scott-Browne, F. Crawford, W. A. Macdonald, P. Marrack, and J. W. Kappler. 2008. Crossreactive T Cells spotlight the germline rules for alphabeta T cell-receptor interactions with MHC molecules. Immunity 28:324-334.
20. Scott-Browne, J. P., J. White, J. W. Kappler, L. Gapin, and P. Marrack. 2009. Germline-encoded amino acids in the alphabeta T-cell receptor control thymic selection. Nature 458:1043-1046.
21. Garcia, K. C., J. J. Adams, D. Feng, and L. K. Ely. 2009. The molecular basis of TCR germline bias for MHC is surprisingly simple. Nat. Immunol. 10:143-147.
22. Reinherz, E. L., K. Tan, L. Tang, P. Kern, J. Liu, Y. Xiong, R. E. Hussey, A. Smolyar, B. Hare, R. Zhang, et al. 1999. The crystal structure of a T cell receptor in complex with peptide and MHC class II. Science 286:1913-1921.
23. Hennecke, J., A. Carfi, and D. C. Wiley. 2000. Structure of a covalently stabilized complex of a human alphabeta T-cell receptor, influenza HA peptide and MHC class II molecule, HLA-DR1. EMBO J. 19:5611-5624.
24. Hahn, M., M. J. Nicholson, J. Pyrdol, and K. W. Wucherpfennig. 2005. Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor. Nat. Immunol. 6:490-496.
25. Li, Y., Y. Huang, J. Lue, J. A. Quandt, R. Martin, and R. A. Mariuzza. 2005. Structure of a human autoimmune TCR bound to a myelin basic protein selfpeptide and a multiple sclerosis-associated MHC class II molecule. EMBO J. 24:2968-2979.
26. Rudolph, M. G., R. L. Stanfield, and I. A. Wilson. 2006. How TCRs bind MHCs, peptides, and coreceptors. Annu. Rev. Immunol. 24:419-466.