Cryptolepine, isolated from Sida acuta, sensitizes human gastric adenocarcinoma cells to TRAIL-induced apoptosis

Phytotherapy Research

Volumn 25, Issue 1, 2011, Pages 147-150

  Ahmed, Firoj ^a   Toume, Kazufumi ^a   Ohtsuki, Takashi ^a   Rahman, Mahmudur ^b   Sadhu, Samir Kumar ^b   Ishibashi, Masami ^a  

^a CHIBA UNIVERSITY   (Japan)

^b KHULNA UNIVERSITY   (Bangladesh)

Author keywords

AGS cell lines; cryptolepine; Malvaceae; Sida acuta; TRAIL induced apoptosis

Indexed keywords

CRYPTOLEPINE; KAEMPFEROL DERIVATIVE; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ANGIOSPERM; APOPTOSIS; ARTICLE; CANCER CELL; CONTROLLED STUDY; CYTOTOXICITY; DRUG ISOLATION; DRUG STRUCTURE; HUMAN; HUMAN CELL; SIDA ACUTA; STOMACH ADENOCARCINOMA;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASE 3; CASPASE 7; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; ENZYME ACTIVATION; GLYCOSIDES; HUMANS; INDOLE ALKALOIDS; MALVACEAE; QUINOLINES; STOMACH NEOPLASMS; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

MALVACEAE; SIDA ACUTA;

EID: 78650660594     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3219     Document Type: Article

References (14)

1. Adhami VM, Malik A, Zaman N, et al,. 2007. Combined inhibitory effects of green tea polyphenols and selective cyclooxygenase-2 inhibitors on the growth of human prostate cancer cells both in vitro and in vivo. Clin Cancer Res 13: 1611-1619.
2. Ahmed F, Ohtsuki T, Aida W, Ishibashi M., 2008. Tyrosine derivatives isolated from Streptomyces sp. IFM 10937 in a screening program for TRAIL-resistance-overcoming activity. J Nat Prod 71: 1963-1966.
3. Dassonneville L, Lansiaux A, Wattelet A, et al,. 2000. Cytotoxicity and cell cycle effects of the plant alkaloids cryptolepine and neocryptolepine: relation to drug-induced apoptosis. Eur J Pharmacol 409: 9-18.
4. Horinaka M, Yoshida T, Shiraishi T, et al,. 2005. Luteolin induces apoptosis via death receptor 5 up-regulation in human malignant tumor cells. Oncogene 24: 7180-7189.
5. Ishibashi M, Ohtsuki T., 2008. Studies on search for bioactive natural products targeting TRAIL signaling leading to tumor cell apoptosis. Med Res Rev 28: 688-714.
6. Karou D, Nadembega WMC, Ilboudo DP, et al,. 2007. Sida acuta Burm. f.: a medicinal plant with numerous potencies. Afr J Biotechnol 6: 2953-2959.
7. Kirtikar KR, Basu BD., 1975. Indian Medicinal Plants, 2nd edn. Bishen Singh-Mahendrapal Singh: India.
8. Laryea D, Isaksson A, Wright CW, Larsson R, Nygren P., 2009. Characterization of the cytotoxic activity of the indoloquinoline alkaloid cryptolepine in human tumour cell lines and primary cultures of tumour cells from patients. Invest New Drugs 27: 402-411.
9. Llobet D, Eritja N, Encinas M, et al,. 2000. CK2 controls TRAIL and Fas sensitivity by regulating FLIP levels in endometrial carcinoma cells. Oncogene 27: 2513-2524.
10. Ohtsuki T, Kikuchi H, Koyano T, Kowithayakorn T, Sakai T, Ishibashi M., 2009. Death receptor 5 promoter-enhancing compounds isolated from Catimbium speciosum and their enhancement effect on TRAIL-induced apoptosis. Bioorg Med Chem 17: 6748-6754.
11. Okuyama T, Hosoyama K, Kiraga Y, Kurono G, Takemoto T., 1978. The constituents of Osmunda spp. II.: A new flavonol glycoside of Osmunda asiatica. Chem Pharm Bull 26: 3071-3074.
12. Srivastava RK., 2001. TRAIL/Apo-2L: Mechanisms and clinical applications in cancer. Neoplasia 3: 535-546.
13. Yang S-W, Abdel-Kader M, Malone S, et al,. 1999. Synthesis and biological evaluation of analogues of cryptolepine, an alkaloid isolated from the Suriname Rainforest. J Nat Prod 62: 976-983.
14. Yoon KD, Jeong DG, Hwang YH, Ryu JM, Kim J., 2007. Inhibitors of osteoclast differentiation from Cephalotaxus koreana. J Nat Prod 70: 2029-2032.