GABAergic regulation of cerebral microvascular tone in the rat

Journal of Cerebral Blood Flow and Metabolism

Volumn 17, Issue 9, 1997, Pages 992-1003

  Fergus, Andrea ^a   Lee, Kevin S ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Blood flow; GABA; Hypoxia; Microcirculation; Microvessels

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR; NITRIC OXIDE;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL TONE; BRAIN BLOOD FLOW; BRAIN BLOOD VESSEL; BRAIN HYPOXIA; GABAERGIC SYSTEM; MALE; MICROCIRCULATION; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030766430     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199709000-00009     Document Type: Article

References (64)

1. Akgören N, Dalgaard P, Lauritzen M (1996) Cerebral blood flow increases evoked by electrical stimulation of rat cerebellar cortex: relation to excitatory synaptic activity and nitric oxide synthesis. Brain Res 710:204-214
2. Alborch E, Torregrosa G, Terrasa JC, Estrada C (1984) GABA receptors mediate cerebral vasodilation in the unanesthetized goat. Brain Res 321:103-110
3. Boeckxstaens GE, Pelckmans PA, Bult H, De Man JG, Herman AG, Van Maercke YM (1991) Evidence for nitric oxide as mediator of non-adrenergic, non-cholinergic relaxations induced by ATP and GABA in the canine gut. Br J Pharmacol 102:434-438
4. Davies CH, Davies SN, Collingridge GL (1990) Paired-pulse depression of monosynaptic GABA-mediated inhibitory postsynaptic responses in rat hippocampus. J Physiol (Lond) 424:513-531
5. B receptors of rat neocortical neurons differ in their pharmacological properties. Neurosci Lett 154:209-212
6. Edvinsson L, Krause DN (1979) Pharmacological characterization of GABA receptors mediating vasodilation of cerebral arteries in vitro. Brain Res 173:89-97
7. Edvinsson L, Larsson B, Skärby T (1980) Effect of the GABA receptor agonist muscimol on regional cerebral blood flow in the rat. Brain Res 185:445-448
8. Fergus A, Jin Y, Thai QA, Kassell NF, Lee KS (1995) Vasodilatory actions of calcitonin gene-related peptide and nitric oxide in parenchymal microvessels of the rat hippocampus. Brain Res 694: 78-84
9. Fergus A, Jin Y, Thai QA, Kassell NF, Lee KS (1996) Tonic PKC-mediated vasoconstriction is unmasked when NOS is inhibited in cerebral microvessels. Neuroscience 74:927-934
10. Fox PT, Raichle ME (1986) Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects. Proc Natl Acad Sci USA 83:1140-1144
11. Fox PT, Raichle M, Minutm MS, Dence C (1988) Nonoxidative glucose consumption during focal physiologic neural activity. Science 241:462-464
12. A/benzodiazepine receptors in acutely isolated hippocampal astrocytes. J Neurosci 15:2720-2732
13. Fraser DD, Mudrick-Dononn LA, MacVicar BA (1994) Astrocytic GABA receptors. Glia 11:83-93
14. Fujiwara M, Muramatsu I (1975) γ-Aminobutyric acid receptor on vascular smooth muscle of dog cerebral arteries. Br J Pharmacol 55:561-562
15. + channels in cat cerebral arterial smooth muscle cell membranes. Pflugers Arch 428:621-630
16. Goodchild CS (1993) GABA receptors and benzodiazepines. Br J Anaesth 71:127-133
17. Gragera RR, Muñiz E, Martinez-Rodriguez R (1993) Electron microscopic immunolocalization of GABA and glutamic acid decarboxylase (GAD) in cerebellar capillaries and their microenvironment. Cell Mol Biol 39:809-817
18. Hamel E, Edvinsson L, MacKenzie ET (1988) Heterogenous vasomotor responses of anatomically distinct feline cerebral arteries. Br J Pharmacol 94:423-426
19. Hamel E, Krause DN, Roberts E (1981) Specific cerebrovascular localization of glutamate decarboxylase activity. Brain Res 223:199-204
20. Hendry SHC, Jones EG, Beinfeld MC (1983) Cholecystokinin-immunoreactive neurons in rat and monkey cerebral cortex make symmetric synapses and have intimate associations with blood vessels. Neurobiology 80:2400-2404
21. Iadecola C, Arneric SP, Baker HD, Tucker LW, Reis DJ (1987) Role of local neurons in cerebrocortical vasodilation elicited from cerebellum. Am J Physiol 252:R1082-R1091
22. Iadecola C, Xu X (1994) Nitro-L-arginine attenuates hypercapnic cerebrovasodilation without affecting cerebral metabolism. Am J Physiol 266:R518-R525
23. Johansson B (1989) Myogenic tone and reactivity: definitions based on muscle physiology. J Hypertens 7:S5-S8
24. Johnson PC (1980) The myogenic response. In: Handbook of Physiology: The Cardiovascular System, vol 2 (Bohr, DF, Somlyo AP, Sparks HV, Geiger SR, eds), Bethesda, MD, American Physiological Society, pp 409-442
25. Kelly PAT, Faulkner AJ, Burrow AP (1989) The effects of the GABA agonist muscimol upon blood flow in different vascular territories of the rat cortex. J Cereb Blood Flow Metab 9:754-758
26. Kelly PAT, McCulloch J (1983) The effects of the GABAergic agonist muscimol upon the relationship between local cerebral blood flow and glucose utilization. Brain Res 258:338-342
27. Kontos HA, Wei EP, Raper AJ, Rosenblum WI, Navari RM, Patterson JL (1978) Role of tissue hypoxia in local regulation of cerebral microcirculation. Am J Physiol 234:H582-H591
28. Krause DN, Roberts E, Wong E, Degener P, Rogers K (1980a) Specific cerebrovascular localization of GABA-related receptors and enzymes. Brain Res Bull 5:173-177
29. 3H]muscimol. Brain Res 185:51-57
30. Lacaille JC, Williams S (1990) Membrane properties of interneurons in stratum oriens-alveus of the CA1 region of rat hippocampus in vitro. Neuroscience 36:346-359
31. 2 of the brain cortex during and after direct electrical stimulation. Pflugers Arch 366:39-44
32. Li J, Iadecola C (1994) Nitric oxide and adenosine mediate vasodilation during functional activation in cerebellar cortex. Neuropharmacology 33:1453-1461
33. Lonart G, Wang J, Johnson KM (1992) Nitric oxide induces neurotransmitter release from hippocampal slices. Eur J Pharmacol 220: 271-272
34. Lou HC, Edvinsson L, MacKenzie ET (1987) The concept of coupling blood flow to brain function: revision required? Ann Neurol 22: 289-297
35. Lyden PD, Hedges B (1992) Protective effect of synaptic inhibition during cerebral ischemia in rats and rabbits. Stroke 23:1463-1470
36. McCulloch J, Kelly PAT, Grome JJ (1981) GABAergic influence upon cerebral metabolism and perfusion. In: Cerebral Microcirculation and Metabolism (Cervós-Navarro J, Fritschka E, eds), New York, Raven Press, pp 189-193.
37. Mellander S (1989) Functional aspects of myogenic vascular control. J Hypertens 7:S21-S30
38. Miles R (1990) Synaptic excitation of inhibitory cells by single CA3 hippocampal pyramidal cells of the guinea-pig in vitro. J Physiol (Lond) 428:61-77
39. Morishita W, Sastry BR (1994) Presynaptic actions of GABA and baclofen in CA1 region of the guinea-pig hippocampus. Neuroscience 61:447-455
40. Nakai M, Iadecola C, Ruggiero DA, Tucker LW, Reis D (1983) Electrical stimulation of cerebellar fastigial nucleus increases cerebral cortical blood flow without change in local metabolism: evidence for an intrinsic system in brain for primary vasodilation. Brain Res 260:35-49
41. 3H]muscimol in rat cerebral vessels. Brain Res 423:109-115
42. B receptor sites in rat cerebrovascular tree. Pharmacol Res 22:337-342
43. Newberry NR, Nicoll RA (1985) Comparison of the action of baclofen with γ-aminobutyric acid on rat hippocampal pyramidal cells in vitro. J Physiol 360:161-185
44. Nilsson GE, Lutz L (1993) Role of GABA in hypoxia tolerance, metabolic depression and hibernation: possible links to neurotransmitter evolution. Comp Biochem Physiol 105C:329-336
45. Okada Y, Ozawa S (1982) The concentration of GABA required for its inhibitory action on the hippocampal pyramidal cell in vitro. In: Problems in GABA Research from Brain to Bacteria (Okada Y, Roberts E, eds), Amsterdam, Excerpta Medica, pp 87-95
46. Okuno T, Itakura T, Lee TJ, Ueno M, Shimuzu M, Komai N (1994) Cerebral pial arterial innervation with special reference to GABAergic innervation. J Auton Nerv Syst (suppl)49:S105-S110
47. B receptors by spontaneously released transmitter. J Neurophysiol 67:227-235
48. B receptor-mediated effects on the spontaneous activity of the longitudinal layer in cat terminal ileum. Gen Pharmacol 22:159-163
49. Roberts E (1988) The establishment of GABA as a neurotransmitter. In: GABA and Benzodiazepine Receptors, vol 1 (Squires R, ed), Boca Raton, CRC Press, pp 1-21
50. Romijn HJ, Janszen AWJW, Van den Bogert C (1994) Permanent increase of immunocytochemical reactivity for γ-aminobutyric acid (GABA), glutamic acid decarboxylase, mitochondrial enzymes, and glial fibrillary acidic protein in rat cerebral cortex damaged by early postnatal hypoxia-ischemia. Acta Neuropathol 87:612-627
51. Sagher O, Zhang XQ, Szeto W, Thai Q-A, Jin Y, Kassell NF, Lee KS (1993) Live computerized videomicroscopy of cerebral microvessels in brain slices. J Cereb Blood Flow Metab 13:676-682
52. Schlotter F, Collins JL, Fergus A, Okonkwo D, Kassell NF, Lee KS (1996) Structural interactions between NOS-positive neurons and blood vessels in the hippocampus. Neuroreport 7:966-968
53. Segovia G, Porras A, Mora F (1994) Effects of a nitric oxide donor on glutamate and GABA release in striatum and hippocampus of the conscious rat. Neuroreport 5:1937-1940
54. Seilicovich A, Duvilanski BH, Pisera D, Theas S, Gimeno M, Rettori V, McCann SM (1995) Nitric oxide inhibits hypothalamic leutinizing hormone-releasing hormone release by releasing γ-aminobutyric acid. Proc Natl Acad Sci USA 92:3421-3424
55. Soltesz I, Mody I (1994) Patch-clamp recordings reveal powerful GABAergic inhibition in dentate hilar neurons. J Neurosci 14:2365-2376
56. Sontheimer H, Waxman SG (1993) Expression of voltage-activated ion channels by astrocytes and oligodendrocytes in the hippocampal slice. J Neurophysiol 70:1863-1873
57. Steffensen SC, Henriksen SJ (1991) Effects of baclofen and bicuculline on inhibition in the fascia dentata and hippocampus regio superior. Brain Res 538:46-53
58. Sternau LL, Lust W, Ricci AJ, Ratcheson R (1989) Role for γ-aminobutyric acid in selective vulnerability in gerbils. Stroke 20:281-287
59. Sturek M, Hermsmeyer K (1986) Calcium and sodium channels in spontaneously contracting vascular muscle cells. Science 233:475-478
60. Takayasu M, Dacey RG (1989) Effects of inhibitory and excitatory amino acid neurotransmitters on isolated cerebral parenchymal arterioles. Brain Res 482:393-396
61. Woodson W, Nitecks L, Ben-Ari Y (1989) Organization of the GABAergic system in the rat hippocampal formation: a quantitative immunocytochemical study. J Comp Neurol 280:254-271
62. A agonists and diazepam in CA1 region of in vitro hippocampal slices from chronic flurazepam-treated rats. J Pharmacol Exp Ther 262:204-211
63. Young RSK, During MJ, Aquila WJ, Tendler D, Ley E (1992) Hypoxia increases extracellular concentrations of excitatory and inhibitory neurotransmitters in subsequently induced seizure: in vivo microdialysis study in the rabbit. Exp Neurol 117:204-209
64. Zinebi F, Fagni L, Hugon M (1988) Decrease of recurrent and feedforward inhibitions under high pressure of helium in rat hippocampal slices. J Pharmacol 153:191-199