Evolving a robust signal transduction pathway from weak cross-talk

Molecular Systems Biology

Volumn 6, Issue , 2010, Pages

  Siryaporn, Albert ^a   Perchuk, Barrett S ^b   Laub, Michael T ^b   Goulian, Mark ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

cross talk; directed evolution; histidine kinase; synthetic biology

Indexed keywords

BACTERIAL PROTEIN; CHEA KINASE; CPXA PROTEIN; PHOSPHATASE; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG; CPXA PROTEIN, E COLI; ESCHERICHIA COLI PROTEIN; OSMOLARITY RESPONSE REGULATOR PROTEINS; OUTER MEMBRANE PROTEIN; PROTEIN KINASE; TRANSACTIVATOR PROTEIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EVOLUTIONARY ADAPTATION; GENE EXPRESSION; GENE INSERTION; GENE INTERACTION; GENE MUTATION; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; DIRECTED MOLECULAR EVOLUTION; ESCHERICHIA COLI; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MUTATION; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN DOMAIN;

AMINO ACID SUBSTITUTION; BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL PROTEINS; DIRECTED MOLECULAR EVOLUTION; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; MUTATION; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN KINASES; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS;

EID: 78650643942     PISSN: 17444292     EISSN: 17444292     Source Type: Journal    
DOI: 10.1038/msb.2010.105     Document Type: Article

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